Comparison of nitrazepam 5 mg with triazolam 0.5 mg in young psychiatric insomniac inpatients DOUBLE‐BLIND SINGLE NIGHT CROSS‐OVER STUDY

Blumenthal, Max; Byring, R.; Koivula, Kimmo

doi:10.1111/j.1600-0447.1980.tb00641.x

Cited by 4 publications

(14 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Triazolam is a short-acting and effective hypnotic (8,9,10). It's elimination half-life is 2.3 h in young individuals (11) which means that the drug does not accumulate in the body when used as a hypnotic (12).…”

mentioning

confidence: 99%

Triazolam as a hypnotic for geriatric patients

Dehlin¹,

Björnson²

1983

Acta Psychiatr Scand

View full text Add to dashboard Cite

Triazolam 0.25 mg was compared with nitrazepam 5 mg as a hypnotic for 26 geriatric inpatients in a double-blind cross-over study. Sleep quantity and quality and psychomotor performance were studied. The sleep quantity and quality were similar for both drugs. There were no statistically significant differences between the two drugs in the psychomotor tests. The results are in contrast to results from other studies and might be explained by the composition of the patient material in the present study.

show abstract

mentioning

confidence: 99%

Triazolam as a hypnotic for geriatric patients

Dehlin¹,

Björnson²

1983

Acta Psychiatr Scand

View full text Add to dashboard Cite

show abstract

“…The mean MMAT score of quality was 85%. The risk of bias across the RCTs is presented in Supplement 3. wards for older adults (54), military personnel (48) or military veterans (62). Across all included studies, there were 1034 adults, with one study not clearly reporting the sample size (54).…”

Section: Study and Participant Characteristicsmentioning

confidence: 99%

“…Of these, two focused exclusively on exercise (50,64). In contrast to several pharmacological interventions (46,48,51), a nonpharmacological intervention with three components of CBT-i (sleep hygiene/psychoeducation, stimulus control and sleep restriction) did not reduce the number of awakenings (47). However, it was associated with reduced sleep latency, reduced time awake after sleep onset, and reduced use of as required insomnia medication (47).…”

Section: Studies Without a Control Groupmentioning

confidence: 99%

“…summarises key features of the 20 included studies which were published between 1968 and 2020. All studies were conducted in highincome countries, spanning four continents: Europe (n = 13, 65%) (45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57), Asia (n = 3, 15%) (58-60) and North America (n = 3, 15%) (61)(62)(63) and Australia (n = 1, 5%) (64). Onethird (n=7) of studies were RCTs (52, 55-58, 60, 61).…”

Section: Study and Participant Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Sleep interventions for adults admitted to psychiatric inpatient settings: a systematic scoping review

Aboaja

Dewa

Perry

et al. 2023

Preprint

View full text Add to dashboard Cite

Sleep disturbances are common, affecting over half of adults with a mental disorder. For those admitted to a psychiatric ward, difficulties with sleep are compounded by factors relating to the inpatient setting. We conducted a scoping review of sleep intervention studies on adults admitted to psychiatric settings. We categorised the different types of sleep interventions and identified the effects on sleep and other health outcomes. Instruments used to measure sleep were also described. The search strategy yielded 2530 studies, of which 20 met the inclusion criteria. There was evidence of more non-pharmacological than pharmacological interventions having been tested in inpatient settings. Results indicated that non-pharmacological interventions based on cognitive behaviour therapy for insomnia improve sleep and may improve mental and physical health. Several distinct sleep measures were used in the studies. Objective sleep measures were not commonly used. Gaps in the literature were identified, highlighting the importance of research into a wider range of sleep interventions tested against a control using objective measures of sleep with evaluation of additional mental and physical health outcomes among adults in the psychiatric inpatient settings.

show abstract

“…Triazolam has an elimination half-lie of 2.3 h (Eberts et al (1981)) and is a shortacting and effective hypnotic (Blumenthal et al (1980), Cloos et d. (1977), Roth et al (1976)). The a-hydroxy metabolite of triazolam has been shown to have some hypnotic activity in animal models, but it is short-acting (t M = 3.9 h) and the amount of nonconjugated a-hydroxy metabolite present in plasma in relation to the parent compound is very small (Eberts et al (1981)).…”

mentioning

confidence: 96%

Comparison of nitrazepam with triazolam in insomniac outpatients

Dahl¹,

Dencker²,

Lundin³

et al. 1982

Acta Psychiatr Scand

View full text Add to dashboard Cite

The short-acting hypnotic, triazolam 0.5 mg, was compared in a 7-day double-blind study with the longer acting drug, nitrazepam 5 mg. Of the 60 patients enrolled, 29 in each drug treatment group completed the study and were evaluated. All significant differences found favoured triazolam. On the first night, triazolam was found to be significantly more effective than nitrazepam in inducing and maintaining sleep and in increasing its overall duration. The patients' subjective preference, reflecting the depth of sleep experienced and the effect of the medication, reached highly significant levels in favour of triazolam. Later in the study the differences between the drugs disappeared although the depth of sleep as judged in the study was better with triazolam.

show abstract

Comparison of nitrazepam 5 mg with triazolam 0.5 mg in young psychiatric insomniac inpatients DOUBLE‐BLIND SINGLE NIGHT CROSS‐OVER STUDY

Cited by 4 publications

References 3 publications

Triazolam as a hypnotic for geriatric patients

Triazolam as a hypnotic for geriatric patients

Sleep interventions for adults admitted to psychiatric inpatient settings: a systematic scoping review

Comparison of nitrazepam with triazolam in insomniac outpatients

Contact Info

Product

Resources

About