Comparison of nonparametric analysis of variance methods: A vote for van der Waerden

Luepsen, Haiko

doi:10.1080/03610918.2017.1353613

Cited by 34 publications

(28 citation statements)

References 3 publications

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“…Demographic, clinical, and lipidomic data are presented as median and interquartile range. Because lipidomic data did not fulfil the assumptions of normality (Shapiro–Wilk test) and homoscedasticity (F test), we applied the Van der Waerden test for between-subjects analysis of variance 56 . Subsequently, Van der Waerden post-hoc tests were performed for pairwise multiple comparisons.…”

Section: Methodsmentioning

confidence: 99%

Cerebrospinal fluid lipidomic biomarker signatures of demyelination for multiple sclerosis and Guillain–Barré syndrome

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Petrovics-Balog

et al. 2020

Sci Rep

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Multiple sclerosis (MS) and Guillain–Barré syndrome (GBS) are demyelinating disorders affecting the central nervous system and peripheral nervous system (PNS), respectively. Cerebrospinal fluid (CSF) is one of the most valuable sources of diagnostic biomarkers in neurological diseases. In the present study high sensitivity shotgun mass spectrometry was used to characterise the CSF lipidome of patients with MS, GBS and controls with non-demyelinating diseases. The quantification of 222 CSF lipid molecular species revealed characteristic changes in the absolute and relative lipid concentrations in MS and GBS compared to the controls. For the GBS group, the fourfold elevation in the total lipid content was a discriminatory and a newly identified feature of PNS demyelination. In contrast, in MS, the accumulation of the myelin-derived cerebrosides represented a specific feature of demyelination. As a common feature of demyelination, we identified upregulated levels of lipid metabolic intermediates. We found strong positive correlation between total protein content and lipid concentrations in both diseases. By exploring the CSF lipidome we demonstrate usefulness of broad-range shotgun lipidomic analysis as a fast and reliable method of biomarker discovery in patients with demyelinating neurological disorders that might be a valuable diagnostic complement to existing examinations.

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Section: Methodsmentioning

confidence: 99%

Cerebrospinal fluid lipidomic biomarker signatures of demyelination for multiple sclerosis and Guillain–Barré syndrome

Péter

Török

Petrovics-Balog

et al. 2020

Sci Rep

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“…However, due to the nature of the scale and its susceptibility to floor effects, this was to be expected and transformations that were conducted accordingly had little influence on the pattern of results. Although non-parametric analyses are generally more suitable for use with non-normally distributed data, nonnormal distributions do not violate the parametric F-test and both parametric and nonparametric tests are equally susceptible to problems associated with heterogeneity of variances (Luepsen, 2017).…”

Section: Discussionmentioning

confidence: 99%

Mental contrasting with implementation intentions increases study time for university students

Clark

Miller

Berry

et al. 2020

Brit J of Edu Psychol

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Background. Goal setting is a core aspect of human behaviour that drives action. The intention to achieve one's goals, however, does not necessarily translate into desired outcomes. Although the mental contrasting with implementation intentions (MCII) strategy has demonstrated strong efficacy, limited investigations have been conducted in a university academic goal-setting context.Aims. The current study sought to investigate the efficacy of MCII in facilitating academic goal attainment in university students.Method. Fifty-eight students from Macquarie University, Australia, were randomly allocated to either MCII or stress management training, and were assessed on their progress towards the target goal of increased hours of study four weeks later. Goal attainment scaling (GAS) facilitated the generation of tailored specific goals and was the primary outcome measure.Results. An analysis of covariance indicated that students trained in MCII achieved significantly better goal outcomes than those trained in stress management for both broad (p = .038) and course-or unit-specific (p = .005) study goals. Conclusions.Results highlight the efficacy of using MCII and GAS in combination to promote increased study time for university students.

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“…Model checking for variance homogeneity were based on the Levene test. For a sound discussion about nonparametric analysis of variance methods see for example [48]. The 30 lipids with the smallest p-value of the F-test were chosen to perform a principle component analysis on the centered and to unit variance scaled data.…”

Section: Methodsmentioning

confidence: 99%

Specific Wheat Fractions Influence Hepatic Fat Metabolism in Diet-Induced Obese Mice

et al. 2019

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Low whole grain consumption is a risk factor for the development of non-communicable diseases such as type 2 diabetes. Dietary fiber and phytochemicals are bioactive grain compounds, which could be involved in mediating these beneficial effects. These compounds are not equally distributed in the wheat grain, but are enriched in the bran and aleurone fractions. As little is known on physiological effects of different wheat fractions, the aim of this study was to investigate this aspect in an obesity model. For twelve weeks, C57BL/6J mice were fed high-fat diets (HFD), supplemented with one of four wheat fractions: whole grain flour, refined white flour, bran, or aleurone. The different diets did not affect body weight, however bran and aleurone decreased liver triglyceride content, and increased hepatic n-3 polyunsaturated fatty acid (PUFA) concentrations. Furthermore, lipidomics analysis revealed increased PUFA concentration in the lipid classes of phosphatidylcholine (PC), PC-ether, and phosphatidylinositol in the plasma of mice fed whole grain, bran, and aleurone supplemented diets, compared to refined white flour. Furthermore, bran, aleurone, and whole grain supplemented diets increased microbial α-diversity, but only bran and aleurone increased the cecal concentrations of short-chain fatty acids. The effects on hepatic lipid metabolism might thus at least partially be mediated by microbiota-dependent mechanisms.

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Comparison of nonparametric analysis of variance methods: A vote for van der Waerden

Cited by 34 publications

References 3 publications

Cerebrospinal fluid lipidomic biomarker signatures of demyelination for multiple sclerosis and Guillain–Barré syndrome

Cerebrospinal fluid lipidomic biomarker signatures of demyelination for multiple sclerosis and Guillain–Barré syndrome

Mental contrasting with implementation intentions increases study time for university students

Specific Wheat Fractions Influence Hepatic Fat Metabolism in Diet-Induced Obese Mice

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