Comparison of nonsurgical periodontal therapy with oral hygiene instruction alone for chronic periodontitis

Abstract

We evaluated changes in clinical variablesand microbiological profiles of periodontopathogens among 56 patients with moderate to severe CP who were randomly assigned to oral hygiene instruction (OHI; n = 28) or nonsurgical periodontal treatment (NSPT; n = 28). Periodontal variables were assessed and subgingival plaque samples were obtained from deep pockets (≥5 mm) at baseline and 3 months after treatment. Real-time polymerase chain reaction was used to quantify Actinobacillus actinomycetemcomitans, Tannerella forsythia, Porphyromonas gingivalis, and Prevotella intermedia. All clinical variables significantly improved in both groups. Improvements in gingival bleeding index (GBI), probing pocket depth (PPD), and periodontal attachment loss (PAL) were significantly greater at 3 months after treatment in the NSPT group. At baseline, the prevalences of all pathogens were high. Significant reductions in microbial count were observed for A. actinomycetemcomitans and T. forsythia (P ≤ 0.05) in the NSPT group. None of the improvements in clinical variables was associated with changes in microbiological profiles. At 3 months after treatment, NSPT was associated with significantly greater improvements in GBI, PPD, and PAL as compared with OHI. A. actinomycetemcomitans and T. forsythia counts were significantly lower in the NSPT group.

The effect of liraglutide on the proliferation, migration, and osteogenic differentiation of human periodontal ligament cells

“…Thus, the goal of periodontitis treatment is to prevent disease progression and to promote periodontal reconstruction by inhibiting plaque biofilm formation and the host immune response. The traditional treatment of periodontitis is mechanical plaque removal and drug treatment . Also, studies have confirmed a correlation between periodontitis and diabetes, and diabetic patients require long‐term hypoglycemic drugs or insulin to control blood glucose.…”

Impact of non-surgical periodontal therapy on serum Resistin and periodontal pathogen in periodontitis patients with obesity

“…NSPT has been shown to provide improvement in clinical parameters namely, Visible Plaque Index (VPI), Gingival Bleeding Index (GBI), Probing Pocket Depth (PPD), Clinical Attachment Level (CAL), as well as reduction inflammation and in periodontal pathogens. NSPT was shown to induce a shift from a pre-dominant Gram negative to a Gram positive subgingival microbiota in the general population [2] and to significantly reduce total bacteria counts and positive sites of P. gingivalis and T. forsythia [3,4]. NSPT is also expected to reduce the serum resistin level, which otherwise is present in higher amount in case of periodontal inflammation with periodontitis patients as compared to healthy individuals [5].…”

Marcadores salivares para a periodontite crônica no diabético tipo 2

“…Esses, variam de específicas ou não específicas. Há a hipótese da placa, e, mais recentemente, a "polimicrobiana sinergia e disbiose" 12,13 . A maioria destas teorias Identificam as bactérias como a principal causa de patogênese 13 .…”