Comparison of Novel Hemostatic Factors and Conventional Risk Factors for Prediction of Coronary Heart Disease

Abstract

Hemostatic status did not add significant predictive power to that provided by conventional CHD risk factors yet was able to substitute effectively for these factors.

Candidate Gene Genotypes, Along with Conventional Risk Factor Assessment, Improve Estimation of Coronary Heart Disease Risk in Healthy UK Men

“…Confidence intervals were calculated as described (23 ). Detection rates (or sensitivities) for a 5% false-positive rate were 4 …”

“…Furthermore, given the multifactorial nature of CHD, lifestyle will set the operational context for genetic variants. Thus, a genotype may be associated with a high CHD risk only with exposure to a certain environment, for example, the reported interaction between smoking and apolipoprotein E genotype (APOE) 4 (10 ). Thus, multiple-locus batteries of genotypes (11 ) may be significantly associated with CHD, but their usefulness over and above CRFs in risk prediction has not been demonstrated.…”

Candidate Gene Genotypes, Along with Conventional Risk Factor Assessment, Improve Estimation of Coronary Heart Disease Risk in Healthy UK Men

“…Confidence intervals were calculated as described (23 ). Detection rates (or sensitivities) for a 5% false-positive rate were 4 Human genes: APOE, apolipoprotein E; UCP2, uncoupling protein 2 (mitochondrial, proton carrier); LPL, lipoprotein lipase; APOA4, apolipoprotein A-IV; IL6, interleukin 6 (interferon ␤2); PECAM1 platelet/endothelial cell adhesion molecule (CD31 antigen); AGTR1, angiotensin II receptor, type 1; AGTR2, angiotensin II receptor, type 2; BDKRB1, bradykinin receptor B1; BDKRB2, bradykinin receptor B2; PPARA, peroxisome proliferator-activated receptor-␣; F7, coagulation factor VII (serum prothrombin conversion accelerator); CETP, cholesteryl ester transfer protein.…”

Thrombin Generation and Atherothrombosis: What Does the Evidence Indicate?

“…Some studies find it increased in unstable angina;36 however, Cooper et al did not find significant associations between F1.2 and a first ischemic event 37. van der Bom found no relation between TG markers and a history of CAD, although they observed a significant increase of D‐dimer and a positive association between thrombin markers and D‐dimer 38…”