Comparison of Ochratoxin, Aflatoxin, and T-2 Toxin for Their Effects on Selected Parameters Related to Digestion and Evidence for Specific Metabolism of Carotenoids in Chickens ,

Osborne, Dennis J.; Huff, W. E.; Hamilton, Pat B.; Burmeister, H. R.

doi:10.3382/ps.0611646

Cited by 77 publications

(41 citation statements)

References 22 publications

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“…Aflatoxin, in chicks showed a strong malabsorption syndrome characterized by steatorrhea, hypocarotenoidemia, and decreased concentrations of bile salts and pancreatic lipase, trypsin, amylase, and RNase, while T-2 characterized by steatorrhea and decreased levels of pancreatic lipase, trypsin, amylase, and RNase [3]. In the same study, ochratoxicosis was evident to show severe hypocarotenoidemia.…”

Section: Mycotoxins Causing Mssupporting

confidence: 49%

Mycotoxins, in a Prospection in the Causes and Treatment of Metabolic Syndrome

Islam¹

2017

IJCAM

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Section: Mycotoxins Causing Mssupporting

confidence: 49%

Mycotoxins, in a Prospection in the Causes and Treatment of Metabolic Syndrome

Islam¹

2017

IJCAM

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“…Briefly, in a previous study, three pathways (PPAR signaling pathway, cysteine and methionine metabolism, and arginine and proline metabolism) have been found to be closely associated with metabolic syndrome, especially obesity 27 . In another study, the digestive system is shown to be impacted by OTA in the high-dose group 28 . Moreover, the carbohydrate metabolism pathway has been identified enriched in the medial-dose group 29 .…”

Section: Discussionmentioning

confidence: 99%

Ochratoxin A induced early hepatotoxicity: new mechanistic insights from microRNA, mRNA and proteomic profiling studies

Yang

Chen

et al. 2014

Sci Rep

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The mycotoxin ochratoxin A (OTA) is found widely in agricultural commodities. OTA can induce various toxicities. In this study, rats were gavaged with OTA for different weeks. Then, the expression of microRNAs, mRNAs and proteins were measured in the rat livers treated with OTA for 13 weeks. Our sequencing data suggests that the medial and the high doses of OTA exert different effects on livers. Five distinctive pathways were induced after OTA treatment as collectively demonstrated at miRNA, mRNA and protein levels. Two (primary bile acid biosynthesis, and metabolism of xenobiotics by cytochrome P450) are directly associated with liver damage, whereas the remaining pathways (arginine and proline metabolism, cysteine and methionine metabolism, and PPAR signaling pathway) cause metabolic disease. This study reveals OTA-induced early hepatotoxicity for the first time by combining multi-omics methods. The novel metabolic pathways may contribute to the pathogenesis of metabolic diseases later in life.O chratoxin A (OTA) is a low molecular weight mycotoxin produced by certain strains of filamentous fungi of the Aspergillus and Penicillium genera and has been detected in a large variety of agricultural commodities. OTA carries potential health-associated risks and has been classified as a possible human carcinogen (group 2B) by the International Agency for Research on Cancer 1 . OTA has previously been found to induce various toxic effects including nephrotoxicity, hepatotoxicity, immunotoxicity, genotoxicity, carcinogenicity, teratogenicity, neurotoxicity and mutagenicity.The liver is one of the major target organs of OTA biotransformation. Although, some early hepatotoxicity studies employed relative high concentrations of OTA and found remarkable liver lesion 2,3 , lower doses of OTA did not provoke significant pathological changes 4-6 . Most of the previous studies have been extensively focused on OTA-induced kidney damage, less on liver. However, it is still unknown how OTA affects the liver which is the largest detoxification organ of body. Therefore, the identification of early hepatotoxicity can be helpful to understand the mechanism of some diseases that may be developed and progressed by OTA in later stage, and to prevent these diseases in early stage to improve human health.Omics approaches, such as transcriptome and proteome, are promising to detect the pathological changes of liver at a molecular level. Till date, omics technology has been employed only in a few studies to understand the mechanism of OTA hepatotoxicity. Moreover, a high-throughput microarray profiling study on HepG2 liver cell transcriptome demonstrated that multiple hepatic metabolism genes are modulated by OTA exposure 7 . In addition, proteomic approaches have helped identify key proteins in the livers of pigs treated with OTA 8 . These omics approaches have widened our view about OTA hepatotoxicity, however the mechanism of OTA actions remains largely unknown.Recently, microRNAs (miRNAs) in animals and plants are shown to play an impor...

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“…On the other hand, the decrease in body weight in the animals fed AFB 1 -contaminated diet alone may be due to the effects of AFB 1 on the balance between orexigenic and anorexigenic circuits that regulate the homeostatic loop of body weight regulation, leading to cachexia [20]. Another mechanism for the reduction of body weight due to AFs ingestion could be that AFs ingestion alters various digestive enzymatic activities that give rise to a malabsorption syndrome, characterized by steatorhea, hypocarotenoidemy, and to lowering of bile, pancreatic lipase, trypsin, and amylase [21]. Similar to our results, [22] reported that decrease in weight gains caused by the AFs corn was eliminated by treatment of the corn with ozone.…”

Section: Resultsmentioning

confidence: 99%

Untitled

2017

MOJT

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Forty eight Sprague-Dawley male rats were divided into six groups including the control group fed standard diet, the group fed on AflatoxinB 1 (AFB 1 ) free wheat treated with ozone gas at 20 ppm for 20 min mixed with standard diet, the group fed on AFB 1 free wheat treated with ozone gas at 40 ppm for 20 min mixed with standard diet, the group fed AFB 1 -contaminated diet (2.5 mg/kg diet), the group fed on AFB 1 -contaminated wheat ozonation at 20 ppm for 20 min mixed with standard diet and the group fed on AFB 1 -contaminated wheat ozonation at 40 ppm for 20 min mixed with standard diet. The results indicated that the animals fed AFB 1 -contaminated diet alone showed a significant decrease in feed intake compared to the control group. Animals fed AFB 1 -contaminated wheat treated with ozone showed a significant improvement in feed intake and body weight compared to group fed AFB 1 -contaminated diet. In addition toanimals fed AFB 1 -contaminated diet (2.5mg/kg diet) untreated for 4 weeks showed a significant increase in levels ofthe biochemical parameters and levels of createnine and uric acid compared to the control group or the groups fed ozone treated wheat alone or the AFB 1 -contaminated wheat treated with ozone gas at 20 and 40 ppm. On the other hand animal fed on AFB 1 -contaminated wheat treated with ozone showed a significant improvement in all tested parameters. The Glutathione reduced (GSH) level decreased in animal feed on AFB 1 -contaminated wheat when compared with the control. Moreover, GSH value in animal feed on contaminated diet after ozonation was related with control group. The histological examination of the liver and kidney tissues showed the animals fed on AFB 1 free diet and treated with ozone showed a significant elimination of the harmful effects in the liver and kidney tissues

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Comparison of Ochratoxin, Aflatoxin, and T-2 Toxin for Their Effects on Selected Parameters Related to Digestion and Evidence for Specific Metabolism of Carotenoids in Chickens ,

Cited by 77 publications

References 22 publications

Mycotoxins, in a Prospection in the Causes and Treatment of Metabolic Syndrome

Mycotoxins, in a Prospection in the Causes and Treatment of Metabolic Syndrome

Ochratoxin A induced early hepatotoxicity: new mechanistic insights from microRNA, mRNA and proteomic profiling studies

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