Comparison of Olanzapine and Risperidone in 367 First-Episode Patients with Non-Affective or Affective Psychosis: Results of an Open Retrospective Medical Record Study

Lambert, Martin; Conus, Philippe; Schimmelmann, Benno Karl Edgar; Eide, P.; Ward, Julianna; Yuen, HP; Schacht, Melanie; Edwards, Jordan; McGorry, Patrick D.

doi:10.1055/s-2005-873155

Cited by 30 publications

(15 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lambert, in study of comparing risperidone with olanzapine in the treatment of the first episode of the affective psychosis showed somehow shorter time to reach the treatment response with olanzapine. [28] This study was open and retrospective and the difference was not significant. Hence, we think our study showed a new significant finding in the velocity of action of the risperidone compared with the other antipsychotics and this must be trialed in future studies, more.…”

Section: Discussionmentioning

confidence: 94%

“…In a controlled study comparing olanzapine versus risperidone, a somehow shorter time were needed to reach the remission in olanzapine group. [28] In a controlled study comparing ziprasidone with risperidone, both agents equally improved psychotic symptom. [29] Another clinical trial compared haloperidol with olanzapine showed that two drugs didn’t have statistically different level of improvement after 24 h of treatment.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Onset of action of atypical and typical antipsychotics in the treatment of acute psychosis

Mousavi¹,

Rostami²,

Sharbafchi³

et al. 2013

J Res Pharm Pract

View full text Add to dashboard Cite

Objective:Antipsychotic medications are the frontline treatment for the most psychotic disorders. The aim of this study is to compare the onset of action of the first and second generation antipsychotics and the rate of their side-effects in the treatment of acute psychosis.Methods:In a double-blind, controlled clinical trial, 40 acute psychotic patients were randomly allocated in four groups and treated with each of the four antipsychotics: olanzapine, risperidone, haloperidol or thiothixene. The onset of action of each drug was assessed by the Positive and Negative Symptoms Scale. The data were analyzed by Wilcoxon (Gehan) survival and Log Rank analysis, using SPSS version 20.0.Findings:Initial response was observed in 97.5% (N = 39) of subjects during 2 weeks of intervention. The mean time to the first response was 6.15 ± 2.9 days and this was significantly shorter for risperidone than others. The most common side-effects were sedation and drug induced Parkinsonism.Conclusion:Risperidone represented shorter onset of action for the treatment of acute psychotic symptoms compared with olanzapine, haloperidol and thiothixene.

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Onset of action of atypical and typical antipsychotics in the treatment of acute psychosis

Mousavi¹,

Rostami²,

Sharbafchi³

et al. 2013

J Res Pharm Pract

View full text Add to dashboard Cite

show abstract

“…Early detection and intervention of psychotic disorders are important issues in mental health practice and research [1,2]. Different strategies have been developed to improve the detection of first episode psychosis both in the prodromal phase and during the first psychotic episode to minimize the delay of treatment after the onset of psychosis [3,4].…”

Section: Introductionmentioning

confidence: 99%

Detection of psychosis by mental health care services; a naturalistic cohort study

Boonstra

Wunderink

Sytema

et al. 2008

Clinical Practice and Epidemiology in Mental Health

View full text Add to dashboard Cite

BackgroundDetection of psychotic disorders is an important issue, since early treatment might improve prognosis. Timely diagnosis of psychotic disorders depends on recognition of psychotic symptoms and their interpretation. The aim of this study is to examine to what extent reported psychotic symptoms are accounted for in clinical diagnosis.MethodsThe medical files of all patients who had a first contact with one of two mental health care services (N = 6477) were screened for reported psychotic symptoms and subsequent clinical diagnosis. Patients who reported psychotic symptoms and who were diagnosed with a psychotic disorder were followed-up for two years to register prescription of antipsychotic treatment and continuity of care.ResultsIn the files of 242 (3.7%) patients specific psychotic symptoms were recorded. 37% of these patients were diagnosed with a non-affective psychotic disorder, 7% with other psychotic disorders and 56% with non-psychotic disorders or no diagnosis at all. About 90% of the patients diagnosed with a psychotic disorder did receive any prescription of antipsychotics, and about 50% were in continuous care during the first 2 years.ConclusionRelatively large proportions of patients presenting with psychotic symptoms were diagnosed with a non-psychotic diagnosis or not diagnosed at all. This applies also to patients reporting at least two or more psychotic symptoms. Although we did not verify the appropriateness of clinical diagnosis, these findings are an indication that psychotic disorders may be underdetected. Improving the diagnostic process in mental health care services may be the most obvious way to promote early intervention in psychosis.

show abstract

“…As in schizophrenia (Gafoor 2010), it is unclear whether some antipsychotics are more efficacious or better tolerated in the early stages of the illness than others. In a small retrospective medical record study of firstepisode acute mania with psychosis, olanzapine was associated with better symptom remission and shorter time to remission than risperidone (Lambert 2005). Results are awaited from a recently concluded trial comparing a combination of lithium plus chlorpromazine with lithium plus olanzapine in firstepisode mania with psychotic features (http://clinicaltrials.gov/ ct2/show/NCT00202293).…”

Section: Depressive Relapsesmentioning

confidence: 99%

Treatment of the early stages of bipolar disorder

Elanjithara¹,

Frangou²,

McGuire³

2011

Adv. psychiatr. treat

View full text Add to dashboard Cite

SummaryFor many patients with bipolar disorder there is a long delay between the onset of illness and receiving a diagnosis and the initiation of treatment. This may have an adverse effect on the clinical outcome. Early intervention in bipolar disorder has received less attention than in schizophrenia, and there are relatively few specialist services in this area. This article reviews the literature on the early detection of bipolar disorder and on the effectiveness of pharmacological, psychological and psychosocial interventions in the early phase of the disorder.

show abstract

Comparison of Olanzapine and Risperidone in 367 First-Episode Patients with Non-Affective or Affective Psychosis: Results of an Open Retrospective Medical Record Study

Cited by 30 publications

References 35 publications

Onset of action of atypical and typical antipsychotics in the treatment of acute psychosis

Onset of action of atypical and typical antipsychotics in the treatment of acute psychosis

Detection of psychosis by mental health care services; a naturalistic cohort study

Treatment of the early stages of bipolar disorder

Contact Info

Product

Resources

About