Comparison of once daily versus twice daily oral nitrates in stable angina pectoris

Profile of carvedilol controlled-release: a new once-daily formulation of carvedilol

“…Overall adherence was significantly increased with once-daily versus twice-daily dosing, and there was a significant reduction in missed doses with the once-daily dosing. This adherence translated into better outcomes; there was a 94% decrease in the mean weekly number of chest pain episodes in the once-daily group and a 30% decrease in the group receiving the twice-daily regimen (p < 0.0001) [55]. In a retrospective analysis of pharmacy claims data of 1-year heart attack survivors, > 90% of MI patients were prescribed β-blockers within 7 days of leaving the hospital.…”

“…Once-daily dosing has lead to better adherence and outcomes than twice-daily dosing in patients with angina who have been treated with nitrates [55]. COMPASS (Compliance with Oral Mononitrates in Angina Pectoris Study) was an open, nonblinded, randomised, parallel-group study involving 101 patients and compared patient adherence (using electronic measurement) and treatment effectiveness in patients with stable angina pectoris who were treated with oral nitrates administered once daily versus twice daily.…”

An education-behavioural intervention improves adherence to statins

“…According to the World Health Organization estimates, non-adherence occurs in about 50% of patients treated for chronic diseases [1]. Studies conducted in Poland confirm its high prevalence, even in case of patients suffering from such a symptomatic condition, as coronary heart disease [2,3]. However, non-adherence is particularly unsatisfactory in asymptomatic diseases, such as hyperlipidemia.…”

Noncompliance in the Use of Cardiovascular Medications in the Medicare Part D Population

“…Patient noncompliance continues to be problematic whether patients suffer from hypertension, coronary artery disease, or the more symptomatic ischemic heart diseasewhere episodes of chest pains due to noncompliance may exist, ( ). Kardas, 2004;Newby et al, 2006 Previous studies addressing noncompliance have considered patient characteristics, such as gender, age, race/ethnic origin, area of residence, dual eligibility enrollment, managed care status, disease burden, and patient out-of-pocket (OOP) costs as potential risk factors for noncompliance ( ). Thus, we still need to identify factors that may explain why patients do not take their medications.…”