Comparison of oncological outcomes of right-sided colon cancer versus left-sided colon cancer after curative resection

Lim, Dong-Jin; Kuk, Jung Kul; Kim, Tae-Hyung; Shin, Eung Jin

doi:10.1097/md.0000000000008241

Cited by 104 publications

(102 citation statements)

References 27 publications

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“…It was observed that patients with right-sided tumors presented a significantly decreased OS compared to left-sided tumors. This phenomenon has also been described previously [39][40][41][42]. Baran B et al reported that treatment response differed among the left and right-sided tumors.…”

Section: Discussionsupporting

confidence: 82%

“…Moreover, the higher antigenic load described in the right-sided tumors is more likely to be due to the defective mismatch repair mechanism because of the high frequency of mutations, thus increasing the possibility of immune recognition [46,47]. Lim DR et al described data from 414 patients under curative resection for right or left-sided colon cancer, suggesting that patients with left-sided tumors had a better survival outcome than those with right-sided tumors, especially in stage III patients [41]. Finally, Ulanja MB et al, in a retrospective analysis of 163,980 patients with colon cancer, concluded that tumor sidedness might affect presentation and survival rates at different stages of the disease.…”

Section: Discussionmentioning

confidence: 99%

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The Prognostic Value of the Detection of Microbial Translocation in the Blood of Colorectal Cancer Patients

Messaritakis

Vogiatzoglou

Tsantaki

et al. 2020

Cancers

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Dysbiosis has been associated with various diseases and is of major health importance. Dysbiosis leads to microbial translocation, which is the passage of microorganisms, their fragments, or their metabolites from the intestinal lumen into the blood circulation and other sites. The aim of the study was to determine whether microbial translocation occurs in stage II/III-IV colorectal cancer (CRC) patients. The aim was also to evaluate the usefulness of blood PCR for diagnosis of such translocation and correlate the presence of toll-like receptor/vitamin D receptor (TLR/VDR) gene polymorphisms with microbial DNA fragments detected in the blood of CRC patients. Three hundred and ninety-seven CRC patients enrolled in the study. Peripheral blood DNA was analyzed using PCR for the amplification of genomic DNA encoding 16S rRNA, the β-galactosidase gene of Escherichia coli, glutamine synthase gene of Bacteroides fragilis, and 5.8S rRNA of Candida albicans. Significantly higher rates of all microbial fragments, but E. coli, detected were observed in the CRC patients (p < 0.001); such detection of all four microbial fragments was also significantly associated with the metastatic disease (p < 0.001), leading to shorter survival rates (p < 0.001). Tumor location in the right colon also significantly correlated with shorter survival (p = 0.016). Individuals with homozygous mutant alleles of TLR/VDR polymorphisms had significantly higher detection rates of microbial DNA fragments. The detection of microbial DNA fragments in CRC patients highlighted the role of these microbes in cancer development, progression, and patients’ survival.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

The Prognostic Value of the Detection of Microbial Translocation in the Blood of Colorectal Cancer Patients

Messaritakis

Vogiatzoglou

Tsantaki

et al. 2020

Cancers

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“…Eklof et al also found that RCC with an increase in BRAF mutations exhibits poor prognosis. Moreover, RCC usually presents with advanced stage, increased tumor size, poorer differentiation, and more node positivity than LCRC, which are related to inferior survival …”

Section: Discussionmentioning

confidence: 99%

Differences in oncological outcomes and inflammatory biomarkers between right‐sided and left‐sided stage I‐III colorectal adenocarcinoma

Guo

Xie

et al. 2019

Clinical Laboratory Analysis

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Background:The aim of this study was to investigate the differences in oncological outcome and inflammatory biomarkers between right-sided colon cancer (RCC) and left-sided colorectal cancer (LCRC). Methods:We retrospectively analyzed 339 patients with stage I-III colorectal cancer, including 125 RCC patients and 214 LCRC patients, who underwent radical resection from January 2012 to January 2014. Comparison of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) between RCC and LCRC was evaluated using the Mann-Whitney U test. Overall survival (OS) and disease-free survival (DFS) were analyzed using Kaplan-Meier analysis and compared using the log-rank test. Univariate and multivariate Cox regression analyses were used to identify the prognostic value of inflammatory markers.Results: Patients with RCC had higher NLR (P = .002) and PLR (P < .001) but lower LMR (P = .002) compared to LCRC. In stage I-III, RCC showed poorer OS and DFS than LCRC (61.6% vs 71.5%, P = .018; 64.8% vs 76.2%, P = .006). Univariate and multivariate analyses indicated that NLR, PLR, and LMR were independent predictors for both OS and DFS in RCC, whereas only PLR was found to be an independent prognostic predictor in LCRC. Conclusion:The prognosis and prognostic value of inflammatory biomarkers were significantly different between RCC and LCRC. Novel therapeutic strategies are needed, and proper prognostic predictors should be selected according to colorectal tumor location. K E Y W O R D Sinflammatory biomarkers, right/left-sided colorectal adenocarcinoma, lymphocyteto-monocyte ratio, neutrophil-to-lymphocyte ratio, oncological outcomes, overall survival, platelet-to-lymphocyte ratio

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“…В ходе исследования обнару-жилось, что в источниках литературы не представлены в полном объеме данные по отдаленным результатам экстренной хирургии рака ОК. В большинстве проведенных исследований и сис-тематических обзоров было продемонстрировано, что показатели 5-летней выживаемости в плановой хирургии рака ОК были несколько лучше при левосто-ронней локализации опухоли по сравнению с право-сторонней [15][16][17][18][19][20]. Так, в исследовании K. Moritani и соавт.…”

Section: Discussionunclassified

“…Lim и соавт. [16], IIIС стадия наблю-далась чаще при правостороннем раке ОК по срав-нению с левосторонним, хотя различия не были ста-тистически значимыми. Кроме того, имеются данные о том, что правосторонний рак ОК имеет более низкую дифференцировку по сравнению с левосторонним, чаще встречается у пациентов более старшего возраста и при правых локализациях рака ОК чаще поражаются апикальные лимфатические узлы [16,21,24], что ока-зывает непосредственное влияние на прогноз заболе-вания.…”

Section: Discussionunclassified

Emergency resections in patients with complicated rightand left-sided colon cancer: long-term outcomes

Щаева¹

2018

Onkol. koloproktol.

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Objective: to evaluate five-year overall and relapse-free survival in patients with complicated rightand left-sided colon cancer that underwent emergency resection.Materials and methods. The study included 501 patients with urgent complications of rightand left-sided colon cancer that underwent emergency resection. The data was obtained from an electronic register containing the information on patients with urgent complications of colorectal cancer treated in general and specialized surgical hospitals in Smolensk between 2001 and 2013 (13 years). We assessed fiveyear overall and relapse-free survival in these patients.Results. A total of 501 resections were performed during the study period. We observed significant differences in resection statuses of patients after emergency resection: the R1 resection status was more frequent in individuals with right-sided colon cancer compared to those with left-sided colon cancer (20.8 % vs. 6.9 %, p = 0.0002). Mean number of lymph nodes examined was 4.6 ± 2.0 in patients with right-sided cancer and 5.3 ± 3.0 in patients with left-sided cancer (p = 0.18). There were no differences in the number of patients receiving adjuvant treatment between the groups (p = 0.11). Patients with left-sided stage II/IIIB/IIIСcomplicated colon cancer demonstrated better overall and relapse-free survival than those with right-sided tumors of the same stages (overall survival: p = 0.007, p = 0.0002, p = 0.0001 for stages II, IIIB, IIIСrespectively; relapse-free survival: p = 0.005, p = 0.0003, p = 0.0002 for stages II, IIIB, IIIСrespectively).Conclusion. The observed differences in the outcomes of treatment for rightand left-sided complicated colon cancer can be explained by the fact that the majority of emergency resections for right-sided tumors were one-stage and were performed in general surgery hospitals. Patients with left-sided cancer underwent tumor removal on the second stage more often than those with right-sided cancer (32 % vs. 13 %). Treatment of patients with complicated colon cancer should be consistent, stepwise, and pathogenetically reasonable.

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Comparison of oncological outcomes of right-sided colon cancer versus left-sided colon cancer after curative resection

Cited by 104 publications

References 27 publications

The Prognostic Value of the Detection of Microbial Translocation in the Blood of Colorectal Cancer Patients

The Prognostic Value of the Detection of Microbial Translocation in the Blood of Colorectal Cancer Patients

Differences in oncological outcomes and inflammatory biomarkers between right‐sided and left‐sided stage I‐III colorectal adenocarcinoma

Emergency resections in patients with complicated rightand left-sided colon cancer: long-term outcomes

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