Comparison of one week and two weeks of triple therapy for the eradication of <i>Helicobacter pylori</i> in a Sri Lankan population: a randomised, controlled study

Abstract

Introduction Resistance of Helicobacter pylori to antibiotics may be particularly high in parts of the tropics. Infection may prove difficult to eradicate in such situations, and there is some evidence of benefit in increasing the duration of treatment (triple therapy) from 1 week to 2 or 3 weeks.

Quality of reporting clinical trials published in five leading Sri Lankan medical journals

“…We retrieved 39 trials for assessment of the quality of reporting, of which 32 (82%) were from the Ceylon Medical Journal. Of 39 trials, 15 (38.5%) were randomized clinical trials and 24 (61.5%) were non‐randomized trials (Table ). All RCTs were parallel group and phase III trials and 11 (73%) published after CONSORT was introduced in 1996.…”

“…Of 39 trials, 15 (38.5%) were randomized clinical trials and 24 (61.5%) were non‐randomized trials (Table ). All RCTs were parallel group and phase III trials and 11 (73%) published after CONSORT was introduced in 1996. Except one which was conducted in India , all the other trials were conducted in Sri Lanka.…”

“…Of 39 trials, 38 (97.4%) had abstracts. Eleven (28%) reported the study design in the title and 23 (59%) in the abstract and 10 (25.6%) in the methods.…”

“…The accepted terminology for the study designs were reported only in 12 (30.7%) trials and 4 (10%) were reported as either prospective studies or descriptive studies in the main manuscripts, and 13 (36%) had not mentioned the study design anywhere of the article, of which 4 (30.7%) were RCTs. Of 14 abstracts of RCTs, 9 (64%) reported that participants were allocated randomly.…”

“…The success of blinding was not evaluated in all blinded trials. Ethical clearance was granted by an Ethics Review Committee was reported by 14 (36%) of all trials and 7 (47%) of RCTs. It is reported that the consent was obtained by 16 (41%) studies.…”