Comparison of opioid receptor distributions in the rat central nervous system

Gray, Andrew; Coupar, Ian M.; White, Paul

doi:10.1016/j.lfs.2006.02.021

Cited by 39 publications

(20 citation statements)

References 80 publications

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“…For example, there are broad colocalizations of MOR and DOR on overlapping populations of neurons in pain-modulating regions of the CNS (Fields et al, 1980;Gray et al, 2006). Coadministration of DOR agonists apparently increases the potency and efficacy of MOR agonists (Sutters et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

In Vivo Characterization of MMP-2200, a Mixed δ/μ Opioid Agonist, in Mice

Lowery

Raymond²,

Giuvelis³

et al. 2010

J Pharmacol Exp Ther

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Section: Introductionmentioning

confidence: 99%

In Vivo Characterization of MMP-2200, a Mixed δ/μ Opioid Agonist, in Mice

Lowery

Raymond²,

Giuvelis³

et al. 2010

J Pharmacol Exp Ther

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“…The cytoplasmic staining may represent the synthesised receptor as it is being cycled to the cell membrane where it becomes functionally active once inserted into the cell membrane. Work by Gray and colleagues studying the distribution of opioid receptors in the rat central nervous system with a similar technique found a comparable pattern of staining (Gray et al, 2006). There are areas for future research arising out of this work.…”

Section: Discussionmentioning

confidence: 63%

Opioid mediated activity and expression of mu and delta opioid receptors in isolated human term non-labouring myometrium

Fanning

McMorrow

Campion

et al. 2013

European Journal of Pharmacology

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TitleOpioid mediated activity and expression of mu and delta opioid receptors in isolated human term non-laboring myometrium AbstractThe existence of opioid receptors in mammalian myometrial tissue is now widely accepted. Previously enkephalin degrading enzymes have been shown to be elevated in pregnant rat uterus and a met-enkephalin analogue has been shown to alter spontaneous contractility of rat myometrium. Here we have undertaken studies to determine the effects of met-enkephalin on in vitro human myometrial contractility and investigate the expression of opioid receptors in pregnant myometrium. Myometrial biopsies were taken from women undergoing elective caesarean delivery at term. Organ bath experiments were used to investigate the effect of the met-enkephalin analogue [D-Ala 2, D-met 5] enkephalin (DAMEA) on spontaneous contractility. A confocal immunofluorescent technique and real time PCR were used to determine the expression of protein and mRNA respectively for two opioid receptor subtypes, mu and delta. DAMEA had a concentration dependent inhibitory effect on contractile activity (1X10 -7 M to 1X10 -4 M; 54% reduction in contractile activity, P<0.001 at 1X10 -4 M concentration). Mu and delta opioid receptor protein sub-types and their respective mRNA were identified in all tissues sampled. This is the first report of opioid receptor expression and of an opioid mediated uterorelaxant action in term human non-laboring myometrium in vitro.

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“…Also, ingestive behaviour was enhanced by ICV and intramuscular (IM) administration of metenkephalin (highly specific ligands of the δ-opioid receptor) in cockerels (McCormack and Denbow 1989). Moreover, DPDPE-induced orexigenic activity was blocked by naltrindole, an antagonist of δ-opioid receptor, suggesting that DPDPE stimulates food intake via δ opioid receptor which has been reported to be expressed in the rat CNS (Gray et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Modulation of opioid-induced feeding behavior by endogenous nitric oxide in neonatal layer-type chicks

2015

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The current study was designed to evaluate the effects of central administration of L-arginine (The precursor of nitric oxide), N(G)-nitro-L-arginine methyl ester (L-NAME), a nitric oxide (NO) synthase inhibitor, selective opioid receptor agonists and involvement of central nitrergic/opioidergic systems on feeding behavior in neonatal layer-type chicks. The results of this study showed that the intracerebroventricular (ICV) injection of L-arginine (400 and 800 nmol) significantly decreased food intake (P < 0.001) but the injection of 200 nmol L-arginine had no effect on cumulative food intake in FD3 chickens (P > 0.05). The ICV injection of L-NAME (200 and 400 nmol) increased food intake (P < 0.001) but 100 nmol of L-NAME had no significant effect (P > 0.05). On the other hand, the co-injection of 100 nmol L-NAME significantly attenuated the anorexigenic effect of 800 nmol L-arginine (P < 0.001). Moreover, the food intake of chicks was significantly decreased by ICV injection of DAMGO (μ-opioid receptor agonist, 125 pmol) (P < 0.001) while both DPDPE (δ-opioid receptor agonist, 40 pmol) and U-50488H (κ-opioid receptor agonist, 30 nmol) significantly stimulated food intake (P < 0.001). In addition, the hypophagic effect of DAMGO was significantly amplified by administration of L-arginine (P < 0.001) while the administration of L-NAME attenuated the hypophagic effect of DAMGO (P < 0.001). In contrast, co-injection of L-arginine or L-NAME with DPDPE had no effect on the hyperphagia induced by DPDPE as well as the hyperphagic effect of U-50488H on food intake was not affected by concurrent injection of L-arginine or L-NAME (P > 0.05). These results suggest that nitrergic and opioidergic systems have an important role on feeding behavior in the CNS of neonatal layer-type chicks and it seems that interaction between them is mediated by μ-opioid receptor.

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Comparison of opioid receptor distributions in the rat central nervous system

Cited by 39 publications

References 80 publications

In Vivo Characterization of MMP-2200, a Mixed δ/μ Opioid Agonist, in Mice

In Vivo Characterization of MMP-2200, a Mixed δ/μ Opioid Agonist, in Mice

Opioid mediated activity and expression of mu and delta opioid receptors in isolated human term non-labouring myometrium

Modulation of opioid-induced feeding behavior by endogenous nitric oxide in neonatal layer-type chicks

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