Comparison of oral ampicillin and doxycycline in the treatment of uncomplicated gonorrhoea.

Enfors, Wera; Eriksson, G

doi:10.1136/sti.51.2.99

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…Nineteen of these studies reported adverse reactions in 569 patients and the safety of 11 drugs was assessed [27][28][29][30][31][32][33][34][36][37][38][39][40][41][44][45][46]49,50]. Similarly, 19 studies focused on oral monotherapy [51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70]. These studies of oral drugs involved 3782 patients, and compared the efficacy of 11 antibiotics.…”

Section: Literature Search Process and Study Characteristicsmentioning

confidence: 99%

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Efficacy and Safety of Injectable and Oral Antibiotics in Treating Gonorrhea: A Systematic Review and Network Meta-Analysis

Yang

Dhital

Naderer

2019

JCM

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Gonorrhea is the second most frequently reported sexually transmitted infectious disease of bacterial origin in the world. Current empiric therapies rely on broad-spectrum antibiotics. However, treatment options are becoming limited due to the rise of drug-resistant gonorrhea. To control the rise of drug-resistant gonorrhea and to identify alternative treatment options, clinicians will have to increasingly rely on experimental evidence for the treatment of gonorrhea patients. Thus, we performed a systematic review and network meta-analysis of all randomized clinical trials about the efficacy and safety of various antibiotic regimens in adults with gonorrhea. We searched all references in Embase and PubMed from the date of their inception to January 2019, and then an updated search was performed in March 2019. Of the 28,843 identified references, 44 fulfilled our selection criteria. We used a network meta-analysis based on a frequentist approach to evaluate the efficacy and safety of 12 injectable and 11 oral antibiotics. The efficacy of treatments was ranked by p score and inconsistency was assessed by a back-calculation method. Certainty of evidence was evaluated by the GRADE system. For injectable drugs, there was no difference in efficacy between a reference antibiotic and other drugs. However, ceftriaxone had significantly better efficacy than cefuroxime (OR, 12.03; cephaloridine (OR, 42.41; kanamycin (OR, 5.45; penicillin (OR, 13.11;, and spectinomycin (OR, 4.70; 95% CI 1.62-13.62). Thus, ceftriaxone was the most effective injectable drug (p score of 0.924). As for oral drugs, azithromycin was the most effective compound (p score of 0.8633). There were no significant differences in safety between injectable and oral treatments. In our systematic review of randomized controlled trials, we found azithromycin and ceftriaxone to be the most effective antibiotics for the treatment of gonorrhea. This is in line with current guidelines which recommend a combination therapy of azithromycin and ceftriaxone for the treatment of gonorrhea due to increased antimicrobial resistance. Our analysis identified gentamicin and ofloxacin as alternative therapeutics to treat drug-resistant gonorrhea.

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Section: Literature Search Process and Study Characteristicsmentioning

confidence: 99%

“…These studies of oral drugs involved 3782 patients, and compared the efficacy of 11 antibiotics. Thirteen of these studies reported side-effects and compared the safety of eight drugs in a total of 219 patients [53][54][55][56][57][58][59][60][61][62][65][66][67].…”

Section: Literature Search Process and Study Characteristicsmentioning

confidence: 99%

Efficacy and Safety of Injectable and Oral Antibiotics in Treating Gonorrhea: A Systematic Review and Network Meta-Analysis

Yang

Dhital

Naderer

2019

JCM

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“…The frequency of infection, the relationships of the different pathogens, and their symptomatological significance have already been reported (Eriksson and Wanger, 1975), as well as the results of the antigonococcal treatment (Enfors and Eriksson, 1975).…”

Section: Resultsmentioning

confidence: 99%

“…However other patients were left untreated during the period of investigation for various reasons, such as lack of co-operation, and the control group eventually contained fifty patients. (Enfors and Eriksson, 1975), so that a very large series would have been required to demonstrate any such effect.…”

Section: Resultsmentioning

confidence: 99%

Treatment of trichomoniasis in females with and without gonorrhoea.

Eriksson¹,

Wanger²

1976

Sexually Transmitted Infections

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Summary 46 women with trichomoniasis and gonorrhoea were treated with nimorazole (300 mg twice daily for 7 days) and a trichomonal cure rate of 90.2 per cent. was noted.In addition, 53 of 112 patients with trichomoniasis but without gonorrhoea, were treated with metronidazole (200 mg three times a day for 7 days) and 59 with nimorazole (300 mg twice daily for 7 days) in a randomized trial. The cure rates were 96 and 90-5 per cent. respectively. There was no significant difference in the results noted in the two groups.Neither the trichomonal infection itself nor the result of antitrichomonal therapy was affected by antigonococcal therapy (one-day treatment with ampicillin or single-dose therapy with doxycycline).No increase was noted in the frequency of candidiasis after antitrichomonal therapy (in patients without gonorrhoea) or after antigonococcal therapy, but there was substantial variation between consecutive specimens in the prevalence of C. albicans.

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Penicillins, cephalosporins and tetracyclines

Klingeren¹

1981

Side Effects of Drugs Annual

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Comparison of oral ampicillin and doxycycline in the treatment of uncomplicated gonorrhoea.

Cited by 5 publications

References 12 publications

Efficacy and Safety of Injectable and Oral Antibiotics in Treating Gonorrhea: A Systematic Review and Network Meta-Analysis

Efficacy and Safety of Injectable and Oral Antibiotics in Treating Gonorrhea: A Systematic Review and Network Meta-Analysis

Treatment of trichomoniasis in females with and without gonorrhoea.

Penicillins, cephalosporins and tetracyclines

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