Comparison of oral flora before and after triple therapy for Helicobacter pylori eradication in patient with gastric disease

Kadota, Tamami; Ogaya, Yuko; Hatakeyama, Rina; Nomura, Ryota; Nakano, Kazuhiko

doi:10.1007/s10266-018-0393-y

Cited by 6 publications

(5 citation statements)

References 34 publications

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“…Because of the progressive decline in lung function, even patients in the stable phase of the disease experience activity limitation and reduced QOL. Currently, one of the most significant treatments for stable COPD in western medicine is antibiotic treatment, but using antibiotics for a long time may lead to many side effects such as osteoporosis, hoarseness, and oral flora derangement, which may cause secondary harm to them [ 18 , 19 ]. Clinical studies have found that most COPD patients show declined respiratory muscle strength and endurance, and by implementing respiratory training, the respiratory muscle strength and endurance of patients can be enhanced to a certain extent.…”

Section: Discussionmentioning

confidence: 99%

Effect of Respiration Training-Assisted Western Medicine Therapy on Activity Tolerance, Pulmonary Function, and Quality of Life of Chronic Obstructive Pulmonary Disease Patients in the Stable Phase

Tong

Cui

Chai

2022

Journal of Healthcare Engineering

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Objective. To explore the effect of respiration training-assisted western medicine therapy on activity tolerance, pulmonary function, and quality of life (QOL) of chronic obstructive pulmonary disease (COPD) patients in the stable phase. Methods. The medical data of 90 COPD patients in the stable phase treated in the respiratory medicine of our hospital (November 2020–November 2021) were chosen for the retrospective analysis, and the patients were split into group A (n = 45, respiration training-assisted western medicine therapy) and group B (n = 45, western medicine therapy) according to the clinical reception order, so as to record and compare the activity tolerance, lung function, and QOL between the groups after intervention. Results. Compared with group B after intervention, group A showed greatly longer mean 6-min walking distance, significantly lower St. George’s Respiratory Questionnaire (SGRQ) score, significantly higher specific airway conductance (sGAW) and level values of various lung function indicators, and significantly lower level values of airway resistance (RAW) and specific airway resistance (sRAW) ( p all<0.001); the total effective rate was significantly higher in group A ( p < 0.05). Conclusion. Respiration training-assisted western medicine therapy is a dependable way to improve the activity tolerance of COPD patients in the stable phase, and such strategy largely improves patients’ lung function and QOL. Deeper studies will be helpful to establish a preferable solution for such patients.

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Section: Discussionmentioning

confidence: 99%

Effect of Respiration Training-Assisted Western Medicine Therapy on Activity Tolerance, Pulmonary Function, and Quality of Life of Chronic Obstructive Pulmonary Disease Patients in the Stable Phase

Tong

Cui

Chai

2022

Journal of Healthcare Engineering

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“…The ureA gene of H. pylori was detected in oral specimens before they started triple antibiotic therapy (potassium-competitive acid blocker, amoxicillin, and clarithromycin) for H. pylori eradication. After this treatment, the gene could no longer be detected (Kadota et al 2019). By contrast, Ogaya et al found a 0% detection rate of oral H. pylori in salivary samples from 40 Japanese children and adolescents who went for root canal treatment without any gastric complaints.…”

Section: Detection Of H Pylori With Molecular Methodsmentioning

confidence: 93%

“…The ureA gene is also quite commonly used in oral H. pylori research. In most of the studies using the ureA gene as an amplification target, the detection rate of H. pylori in samples from the oral cavity ranges from 15% to 50.4% when considering all experimental subjects (Song et al 1999;Boyanova et al 2013;Bharath et al 2014;Ogaya et al 2015;Medina et al 2017;Nomura et al 2018;Hamada et al 2019;Kadota et al 2019). Kadota et al described the case of a 29-year-old woman with the chief complaint of a stomach ache.…”

Section: Detection Of H Pylori With Molecular Methodsmentioning

confidence: 99%

Colonization ofHelicobacter pyloriin the oral cavity – an endless controversy?

Mao

Jakubovics

Bächle

et al. 2021

Critical Reviews in Microbiology

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Helicobacter pylori is associated with chronic gastritis, gastric or duodenal ulcers, and gastric cancer. Since the oral cavity is the entry port and the first component of the gastrointestinal system, the oral cavity has been discussed as a potential reservoir of H. pylori. Accordingly, a potential oral-oral transmission route of H. pylori raises the question concerning whether close contact such as kissing or sharing a meal can cause the transmission of H. pylori. Therefore, this topic has been investigated in many studies, applying different techniques for detection of H. pylori from oral samples, i.e. molecular techniques, immunological or biochemical methods and traditional culture techniques. While molecular, immunological or biochemical methods usually yield high detection rates, there is no definitive evidence that H. pylori has ever been isolated from the oral cavity. The specificity of those methods may be limited due to potential cross-reactivity, especially with H. pylori-like microorganisms such as Campylobacter spp. Furthermore, the influence of gastroesophageal reflux has not been investigated so far. This review aims to summarize and critically discuss previous studies investigating the potential colonization of H. pylori in the oral cavity and suggest novel research directions for targeting this critical research question.

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“…Furthermore, closely related H. pylori species are not detected using this method [13]. We found that this novel nested PCR method detects H. pylori in samples of oral cavity tissues acquired from subjects of all ages [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 94%

Distribution of Helicobacter pylori and Periodontopathic Bacterial Species in the Oral Cavity

et al. 2020

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The oral cavity may serve as a reservoir of Helicobacter pylori. However, the factors required for H. pylori colonization are unknown. Here, we analyzed the relationship between the presence of H. pylori in the oral cavity and that of major periodontopathic bacterial species. Nested PCR was performed to detect H. pylori and these bacterial species in specimens of saliva, dental plaque, and dental pulp of 39 subjects. H. pylori was detected in seven dental plaque samples (17.9%), two saliva specimens (5.1%), and one dental pulp (2.6%) specimen. The periodontal pockets around the teeth, from which dental plaque specimens were collected, were significantly deeper in H. pylori-positive than H. pylori-negative subjects (p < 0.05). Furthermore, Porphyromonas gingivalis, a major periodontopathic pathogen, was detected at a significantly higher frequency in H. pylori-positive than in H. pylori-negative dental plaque specimens (p < 0.05). The distribution of genes encoding fimbriae (fimA), involved in the periodontal pathogenicity of P. gingivalis, differed between H. pylori-positive and H. pylori-negative subjects. We conclude that H. pylori can be present in the oral cavity along with specific periodontopathic bacterial species, although its interaction with these bacteria is not clear.

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Comparison of oral flora before and after triple therapy for Helicobacter pylori eradication in patient with gastric disease

Cited by 6 publications

References 34 publications

Effect of Respiration Training-Assisted Western Medicine Therapy on Activity Tolerance, Pulmonary Function, and Quality of Life of Chronic Obstructive Pulmonary Disease Patients in the Stable Phase

Effect of Respiration Training-Assisted Western Medicine Therapy on Activity Tolerance, Pulmonary Function, and Quality of Life of Chronic Obstructive Pulmonary Disease Patients in the Stable Phase

Colonization ofHelicobacter pyloriin the oral cavity – an endless controversy?

Distribution of Helicobacter pylori and Periodontopathic Bacterial Species in the Oral Cavity

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