Comparison of orlistat and orlistat plus metformin therapy between diabetic and nondiabetic groups

Kişioğlu, Savaş Volkan; Karakullukçu, Serdar; Tufekci, Damla; Demir, Ahmet Suat; Coskun, Hulya; Nuhoğlu, İrfan; Koçak, Mustafa; Ersöz, Halil Önder

doi:10.1590/1806-9282.20230174

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…In recent years, although many diet pills have played a certain role in the short-term treatment of obesity, they also exert significant impacts on patients' physical and mental health. For instance, Orlistat Capsules, as a typical weight loss product in the market, prevent fat absorption by inhibiting gut enzymes that absorb fat [20,21]. However, this has been confirmed to cause adverse reactions such as diarrhea, abdominal pain and liver toxicity.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Potential of Lotus Leaf and Its Bioactive Compounds for Anti-obesity Interventions

Chen,

Zhang,

Zhang

et al. 2024

J. Exp. Clin. Appl. Chin. Med

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The complex syndrome of obesity is a complex syndrome associated with various metabolic disorders, poses significant threats to human health. Many weight loss medications have the potential to rapidly treat obesity, however their toxicity and adverse effects may compromise patients' physiological and psychological well-being. In China, the concept of drug and food homology has been utilized for thousands of years, with lotus leaves serving as a representative example. The lotus leaves have been traditionally used for heat-clearing and lipid-lowering purposes, as well as for cooling the blood and promoting hemostasis, since ancient times. This review represents the first attempt to qualitatively investigate the anti-obesity properties of lotus leaves by integrating gene-disease association databases and drug-target databases for analysis. Additionally, it summarizes the identified monomers in lotus leaves that have been reported to possess functions associated with anti-obesity. The aim of this study is to provide a comprehensive review of the research progress on anti-obesity drugs derived from lotus leaves, and to facilitate further research and development in the field of anti-obesity medication targeting adiposity.

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Section: Introductionmentioning

confidence: 99%

Exploring the Potential of Lotus Leaf and Its Bioactive Compounds for Anti-obesity Interventions

Chen,

Zhang,

Zhang

et al. 2024

J. Exp. Clin. Appl. Chin. Med

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Exploration of the Mechanism of Guaijaverin in Inhibiting Pancreatic Lipase Based on Multispectral Method, Molecular Docking, and Oral Lipid Tolerance Test in Rats

Gao,

Jia,

et al. 2024

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This study aims to investigate the action mechanism of guaijaverin on pancreatic lipase from multiple perspectives and provide a theoretical basis for the search for new pancreatic lipase inhibitors. The inhibition of pancreatic lipase by guaijaverin was investigated through enzyme inhibition activity experiments, and the IC50 was calculated to determine the type of inhibition of guaijaverin. The mechanism of action was studied by measuring fluorescence, ultraviolet spectra, and circular dichroism. Molecular docking technology was used to explore the binding situation. In addition, in vivo oral lipid tolerance tests in rats were carried out to investigate the inhibitory effect of guaijaverin on pancreatic lipase. Guaijaverin inhibited pancreatic lipase up to 90.63%, confirming its excellent inhibitory ability. The inhibition type was noncompetitive inhibition in reversible inhibition. The multispectral experiments indicated that its quenching type was static quenching and guaijaverin changed the microenvironment and spatial conformation of pancreatic lipase. The molecular docking results showed that the minimum binding energy between the two compounds was −6.96 kcal/mol. In vivo experiments demonstrated that guaijaverin inhibits pancreatic lipase by reducing TG uptake in the body. Guaijaverin has excellent inhibitory effects on pancreatic lipase and has the potential to function as a pancreatic lipase inhibitor.

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Comparison of orlistat and orlistat plus metformin therapy between diabetic and nondiabetic groups

Cited by 2 publications

References 22 publications

Exploring the Potential of Lotus Leaf and Its Bioactive Compounds for Anti-obesity Interventions

Exploring the Potential of Lotus Leaf and Its Bioactive Compounds for Anti-obesity Interventions

Exploration of the Mechanism of Guaijaverin in Inhibiting Pancreatic Lipase Based on Multispectral Method, Molecular Docking, and Oral Lipid Tolerance Test in Rats

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