Comparison of Osteochondral Autologous Transplantation, Microfracture, or Debridement Techniques in Articular Cartilage Lesions Associated With Anterior Cruciate Ligament Injury: A Prospective Study With a 3-Year Follow-up

Gudas, Rimtautas; Gudaitė, Agnė; Mickevičius, Tomas; Masiulis, Nerijus; Simonaitytė, Rasa; Čekanauskas, Emilis; Skurvydas, Albertas

doi:10.1016/j.arthro.2012.06.009

Cited by 137 publications

(94 citation statements)

References 42 publications

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“…Treatment options range from palliative (chondroplasty or debridement) to repair (microfracture) to restoration techniques (OATs, ACI, osteochondral allograft, or synthetic scaffold plugs), with widely variable reports of success. While more recent evidence suggests that restoration procedures are superior to repair, 1,2,7,8 there is no consensus on the gold standard among cartilage restoration procedures. These restoration procedures have the capability of providing pain relief, while also potentially delaying the progression of degenerative joint disease.…”

Section: Discussionmentioning

confidence: 99%

Acute Delamination of Commercially Available Decellularized Osteochondral Allograft Plugs

et al. 2016

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Articular cartilage injuries, and corresponding surgical procedures, are occurring with increasing frequency as identified by a review of recent surgical trends. Concerns have grown in recent years regarding the longevity of results following microfracture, with a shift toward cartilage restoration procedures in recent years. This case report describes 2 cases of acute failure following the use of commercially available osteochondral allograft plugs used for the treatment of osteochondral defects of the distal femur. In both cases the chondral surface of the plug delaminated from the underlying cancellous bone, resulting in persistent pain and swelling requiring reoperation and removal of the loose fragments. Caution should be employed when considering use of these plugs for the treatment of osteochondral lesions, as similar outcomes have not been noted with other cartilage restoration techniques.

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Section: Discussionmentioning

confidence: 99%

Acute Delamination of Commercially Available Decellularized Osteochondral Allograft Plugs

et al. 2016

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“…14 MRI is very useful for demonstrating graft incorporation following OAT (Figure 4). Recent medium to long-term prospective studies by Gudas and colleagues 11,12 comparing OAT with microfracture and debridement for osteochondral lesions in the knee have demonstrated better outcomes with OAT. A recent systematic review consisting of level I and level II studies also demonstrated good outcomes with OAT of the knee, with most athletes returning to competitive activity by 6 months.…”

Section: Osteochondral Autograft Transplantation (Oat)mentioning

confidence: 99%

Current Concepts

Kirsch

Thomas

Bedi

et al. 2016

Hand (New York, N,Y.)

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Background: Osteochondritis dissecans (OCD) of the capitellum is a painful condition, which often affects young throwing athletes. Our current understanding regarding the etiology, risks factors, diagnosis, and efficacy of the available treatment options has expanded over recent years, however remains suboptimal. Recent data on patient-reported outcomes following osteochondral autograft transplantation (OAT) for the treatment of large osteochondral lesions of the capitellum have been promising but limited. This review seeks to critically analyze and summarize the available literature on the etiology, diagnosis, and reported outcomes associated with OCD of the capitellum and the use of OAT for its treatment. Methods: A comprehensive literature search was conducted. Unique and customized search strategies were formulated in PubMed, Embase, Scopus, Web of Science, and CENTRAL. Combinations of keywords and controlled vocabulary terms were utilized in order to cast a broad net. Relevant clinical, biomechanical, anatomic and imaging studies were reviewed along with recent review articles, and case series. Results: Forty-three articles from our initial literature search were found to be relevant for this review. The majority of these articles were either review articles, clinical studies, anatomic or imaging studies or biomechanical studies. Conclusions: Current evidence suggests that OAT may lead to better and more consistent outcomes than previously described methods for treating large OCD lesions of the capitellum.

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“…67 This does not refer to the Sanofi biosurgery registered MACI Ò product. Several articles have evaluated side-by-side performance of ACI, MF, and mosaicplasty over long periods 5,68,69 and have produced recommendations factoring in the age and nature of cartilage injury (stage of OA and size of the lesion). In one study, both MF and osteochondral autograft transplantation procedure (OATS) showed encouraging clinical results for athletes under the age of 40 with the OATS group producing slightly increased results over MF, assessed over a period of 37.1 months.…”

Section: Surgical Techniquesmentioning

confidence: 99%

“…[1][2][3] Current surgical treatment paradigms range from microfracture (MF) for initial impact injuries to total knee replacement in advanced cases; however, there are no universally agreed upon solutions that have unequivocally been shown to regenerate fully structural and functional cartilage. [4][5][6][7][8] Specialized surgical treatments, such as autologous chondrocyte implantation (ACI), have emerged over the past few decades and have often been used among younger patients. However, ACI has not been as successful for longterm treatment of older patients.…”

mentioning

confidence: 99%

A Road Map to Commercialization of Cartilage Therapy in the United States of America

Sridharan

Detamore

2016

Tissue Engineering Part B: Reviews

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Comparison of Osteochondral Autologous Transplantation, Microfracture, or Debridement Techniques in Articular Cartilage Lesions Associated With Anterior Cruciate Ligament Injury: A Prospective Study With a 3-Year Follow-up

Cited by 137 publications

References 42 publications

Acute Delamination of Commercially Available Decellularized Osteochondral Allograft Plugs

Acute Delamination of Commercially Available Decellularized Osteochondral Allograft Plugs

Current Concepts

A Road Map to Commercialization of Cartilage Therapy in the United States of America

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