Comparison of outbred lines of chickens for resistance to experimental infection with coccidiosis (Eimeria tenella)

Laan, Maris; Monvoisin, J. L.; Pery, P.; Hamet, N.; Thomas, Mair E. M.

doi:10.1093/ps/77.2.185

Cited by 80 publications

(49 citation statements)

References 20 publications

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“…In susceptible birds, higher frequency of BB genotype (0.7) was observed in Hy-line strain and could use as a marker genotype for susceptibility to infection. However, a near frequency of AB (0.6) and BB (0.4) genotype was observed in Fayoumi breed and this result may be due to the Fayoumi breed is highly conserved as it not undergoes selection as in other commercial breeds (Pinard-vander Laan et al 1998). So, it did not show variation in genotype as in case of Hy-line strain.…”

Section: Genotype Frequencymentioning

confidence: 85%

Polymorphisms of TLR4 Gene and Its Association With Genetic Resistance to Salmonella Enteritidis Infection in Fayoumi Breed and Hy-line Strain in Egypt

Khatab¹,

Hemeda²,

El‐Nahas³

et al. 2017

AJVS

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Key words:Toll-like receptor, polymorphism, genetic resistance, salmonella enteritidis, chickenThe aim of this study is to investigate the polymorphism in exon1 and 2 of TLR4 gene and its possible association with resistance to salmonella infection in the Fayoumi breed and Hyline strain of chickens and its possible association with immune response of birds under study. Two experiments were done, in which the chicks were infected intraesophageal with two different doses of S. enteritidis LD 50 (10 8 cfu) in experiment I and 1/2 LD 50 (5× 10 7 cfu) in experiment II. The birds (100 chicks from each breed) allocated into different groups according to the clinical signs in experiment I to susceptible and resistant and in experiment II, to high and low immune response groups based on ELISA test. TLR4 gene was genotyped by PCR-RFLP of exon 1 (596 bp) and exon 2 (793 bp) using different restriction enzymes. Comparison between the different genotypes generated by Taq1 of Fayoumi breed and Hy-line strain in experiment I and II give valuable result. Exon 1-Taq1 AA genotype can be used as a marker for culling the birds of Hy-line strain as it appears in low immune response and also, BB genotype (0.7) in susceptible birds. Moreover, using exon 2-EcoR-1 BB genotype (0.9) in susceptible birds as a marker for culling these birds. We concluded that the Polymorphisms of TLR4 -exon 1 and 2 can be used as a marker-assisted selection for resistant and/or susceptibility to salmonella infection in Hy-line strain.

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Section: Genotype Frequencymentioning

confidence: 85%

Polymorphisms of TLR4 Gene and Its Association With Genetic Resistance to Salmonella Enteritidis Infection in Fayoumi Breed and Hy-line Strain in Egypt

Khatab¹,

Hemeda²,

El‐Nahas³

et al. 2017

AJVS

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“…One may distinguish between resistance to infection (True resistance) and resistance to disease development (Disease tolerance). To describe resistance to coccidia infection in chickens Pinard-van der Laan et al (1998) combined direct markers, which measure the pathogenic agent (oocyst production), and indirect markers, which assess disruptions induced by the disease (Body weight, caecal lesion at slaughter, mortality, plasma colouration). Our study combined three digestive stresses: one was induced by a specific pathogenic agent (coccidia), one was a non-specific enteritis (fibre deficiency) and the pathogenic agents of the third one were not known.…”

Section: Discussionmentioning

confidence: 99%

Genetic variability of the resistance for three types of enteropathy in the growing rabbit

Rochambeau¹,

Licois²,

Gidenne³

et al. 2006

Livestock Science

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“…Differences were also reported between IAH light Sussex chickens and the same inbred lines (Smith et al, 2002). Large differences have also been reported in outbred populations both for resistance to infection and for the impact of infection on production traits (Pinard-van der Laan et al, 1998). A QTL has been identified that is associated with oocyst shedding (Zhu et al, 2003).…”

Section: Coccidiosismentioning

confidence: 97%

An assessment of opportunities to dissect host genetic variation in resistance to infectious diseases in livestock

Davies

Genini

Bishop

et al. 2009

Animal

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This paper reviews the evidence for host genetic variation in resistance to infectious diseases for a wide variety of diseases of economic importance in poultry, cattle, pig, sheep and Atlantic salmon. Further, it develops a method of ranking each disease in terms of its overall impact, and combines this ranking with published evidence for host genetic variation and information on the current state of genomic tools in each host species. The outcome is an overall ranking of the amenability of each disease to genomic studies that dissect host genetic variation in resistance. Six disease-based assessment criteria were defined: industry concern, economic impact, public concern, threat to food safety or zoonotic potential, impact on animal welfare and threat to international trade barriers. For each category, a subjective score was assigned to each disease according to the relative strength of evidence, impact, concern or threat posed by that particular disease, and the scores were summed across categories. Evidence for host genetic variation in resistance was determined from available published data, including breed comparison, heritability studies, quantitative trait loci (QTL) studies, evidence of candidate genes with significant effects, data on pathogen sequence and on host gene expression analyses. In total, 16 poultry diseases, 13 cattle diseases, nine pig diseases, 11 sheep diseases and three Atlantic salmon diseases were assessed. The top-ranking diseases or pathogens, i.e. those most amenable to studies dissecting host genetic variation, were Salmonella in poultry, bovine mastitis, Marek’s disease and coccidiosis, both in poultry. The top-ranking diseases or pathogens in pigs, sheep and Atlantic salmon wereEscherichia coli, mastitis and infectious pancreatic necrosis, respectively. These rankings summarise the current state of knowledge for each disease and broadly, although not entirely, reflect current international research efforts. They will alter as more information becomes available and as genome tools become more sophisticated for each species. It is suggested that this approach could be used to rank diseases from other perspectives as well, e.g. in terms of disease control strategies.

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Comparison of outbred lines of chickens for resistance to experimental infection with coccidiosis (Eimeria tenella)

Cited by 80 publications

References 20 publications

Polymorphisms of TLR4 Gene and Its Association With Genetic Resistance to Salmonella Enteritidis Infection in Fayoumi Breed and Hy-line Strain in Egypt

Polymorphisms of TLR4 Gene and Its Association With Genetic Resistance to Salmonella Enteritidis Infection in Fayoumi Breed and Hy-line Strain in Egypt

Genetic variability of the resistance for three types of enteropathy in the growing rabbit

An assessment of opportunities to dissect host genetic variation in resistance to infectious diseases in livestock

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