Comparison of outcome measures for patients with chronic obstructive pulmonary disease (COPD) in an outpatient setting.

Harper, R.; Brazier, John; Waterhouse, J C; Walters, Stephen J; Jones, Norman; Howard, P

doi:10.1136/thx.52.10.879

Cited by 198 publications

(139 citation statements)

References 15 publications

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“…We also demonstrated that health status instruments can provide additional information to supplement the other clinical and physiological measures used in clinical research. The results of our study, in terms of reliability, validity and responsiveness, did not clearly favour one instrument over another, as previously shown in other studies (28,33,34). As expected, the symptoms dimension domain of the SGRQ cannot be used to assess acute changes from a given therapy.…”

Section: Resultssupporting

confidence: 67%

French‐Canadian Version of the Chronic Respiratory and of the St George′s Respiratory Questionnaires: An Assessment of their Psychometric Properties in Patients with Chronic Obstructive Pulmonary Disease

Bourbeau

Maltais

Rouleau

et al. 2004

Canadian Respiratory Journal

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BACKGROUND: French versions of the Chronic Respiratory Questionnaire (CRQ) and the St George's Respiratory Questionnaire (SGRQ) have largely been used in Canada, although the process by which they were translated remains unknown and the psychometric properties of these translated versions have not been assessed in a properly designed study. OBJECTIVE: To translate and evaluate the psychometric properties of the French-Canadian versions of the CRQ and the SGRQ. METHODS: The questionnaires were translated according to standardized guidelines for cross-cultural adaptation. Measurements were made at baseline and again after two weeks in 27 chronic obstructive pulomonary disease (COPD) patients known to have stable disease. Measurements were also taken pre-and post-treatment in patients with acute exacerbation of COPD (33 patients) or in pulmonary rehabilitation (32 patients). RESULTS:The CRQ showed high test-retest reliability (the majority above 0.70), although it was slightly lower for the dyspnea dimension (0.58 to 0.65). The SGRQ also showed high test-retest reliability (above 0.80), although it was lower for the symptoms dimension (0.54 to 0.58). The internal consistency reliability coefficients ranged from 0.73 to 0.90 for the CRQ and above 0.80 for the SGRQ, except for the symptoms dimension. The Pearson's correlation coefficients were low (less than 0.30) between most of the translated questionnaire dimension scores and forced expiratory volume in 1 s, 6 min walking test and dyspnea measures. The correlation was generally high (greater than 0.50) between the two questionnaires and the 36-item short form health survey, and for those domains that measured the same construct. The changes in the total and subscale scores of the CRQ and the SGRQ (except for the symptoms domain) were all largely above the variability of the score in the stable disease group. CONCLUSION: The present study confirms that the FrenchCanadian translated versions of the CRQ and the SGRQ perform well with respect to their psychometric properties. They are both suitable for their intended purpose, ie, to detect change in health status in patients with COPD when assessing if a treatment is beneficial. However, the symptoms domain of the SGRQ cannot be used to assess acute change with respect to a given therapy. RÉSULTATS : Le CRQ a montré une bonne fiabilité de test-retest (audessus de 0,70 dans la plupart des cas), même si celle-ci était légèrement inférieure (0,58-0,65) à l'égard de la dyspnée. Le SGRQ a aussi montré une bonne fiabilité de test-retest (au-dessus de 0,80), même si celle-ci était légèrement inférieure (0,54-0,58) à l'égard des symptômes. Les coefficients de cohérence interne variaient entre 0,73 et 0,90 pour le CRQ et ils se tenaient au-dessus de 0,80 pour le SGRQ, sauf en ce qui concerne les symptômes. Les coefficients de corrélation de Bravais-Pearson étaient faibles (inférieurs à 0,30) entre la plupart des résultats des différents aspects dans les questionnaires traduits et le volume expiratoire maximal par seconde, l'ép...

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Section: Resultssupporting

confidence: 67%

French‐Canadian Version of the Chronic Respiratory and of the St George′s Respiratory Questionnaires: An Assessment of their Psychometric Properties in Patients with Chronic Obstructive Pulmonary Disease

Bourbeau

Maltais

Rouleau

et al. 2004

Canadian Respiratory Journal

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“…While differences between this economic subsample and the full sample are not statistically significant, we are limited in our ability to detect differences between the two arms due to the smaller sample size. This problem is perhaps compounded by the possible insensitivity of the EQ-5D seen in several studies (Harper et al, 1997;Nicholl et al, 2001;Patel et al, 2004). Taken together, the lack of a clear pattern in the QALY estimates shown in Table 5 is difficult to interpret.…”

Section: Discussionmentioning

confidence: 49%

Quality of life and cost-effectiveness of interferon-alpha in malignant melanoma: results from randomised trial

et al. 2006

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A definitive conclusion regarding the value of low-dose extended duration adjuvant interferon-alpha therapy in the treatment of malignant melanoma is only possible once data on health-related quality of life (HRQoL) and costs have been considered. This trial randomised 674 patients to interferon alpha-2a (3 megaunits three times per week for 2 years or until recurrence) or placebo. Health-related quality of life (QoL) was to be assessed up to 60 months using the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30. Data for the economic analysis, including cost information and the EQ-5D were also collected. Patients in the observation (OBS) group had significantly better mean follow-up quality of on five dimensions of the EORTC QLQ-C30 functional scales: role functioning (P ¼ 0.033), emotional functioning (P ¼ 0.003), cognitive functioning (P ¼ 0.001), social functioning (P ¼ 0.003) and global health status (P ¼ 0.001). Patients in the OBS group had significantly better mean follow-up symptom scores on seven dimensions of the EORTC QLQ-C30 V1 symptom scales. Economic data showed that costs were d3066 higher in the interferon group and produces an incremental cost per quality-adjusted life year of d41 432 at 5 years. The results show that interferon has significant effects on QoL and symptomatology and is unlikely to be cost-effective in this patient group in the UK.

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“…However, Professor Dowie seems sceptical as to the empirical evidence regarding the sensitivity of CSMs over generics. We agree there are cases that do not support this common claim in the psychometric literature [3], but equally there are many where this has been found including: EQ-5D in chronic pulmonary disease [4] and in cosmetic surgery [5], the SF-36 in urinary incontinence [6] and the example of urinary incontinence that he provides [7]. Copyright The main concern people have with generic measures is that their domains are too far removed from those of the patient and are often irrelevant to the condition.…”

mentioning

confidence: 79%

Measures of health‐related quality of life in an imperfect world: a comment on Dowie

Brazier

Fitzpatrick

2002

Health Economics

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Comparison of outcome measures for patients with chronic obstructive pulmonary disease (COPD) in an outpatient setting.

Abstract: Evidence from this study supports the CRQ and the SF-36 as comprehensive outcome measures for patients with longstanding COPD.

Cited by 198 publications

References 15 publications

French‐Canadian Version of the Chronic Respiratory and of the St George′s Respiratory Questionnaires: An Assessment of their Psychometric Properties in Patients with Chronic Obstructive Pulmonary Disease

French‐Canadian Version of the Chronic Respiratory and of the St George′s Respiratory Questionnaires: An Assessment of their Psychometric Properties in Patients with Chronic Obstructive Pulmonary Disease

Quality of life and cost-effectiveness of interferon-alpha in malignant melanoma: results from randomised trial

Measures of health‐related quality of life in an imperfect world: a comment on Dowie

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