Comparison of outcomes of twins conceived spontaneously and by artificial reproductive therapy

Anbazhagan, A; Hunter, Alyson; Breathnach, Fionnuala; McAuliffe, Fionnuala M.; Geary, Michael; Daly, Seán; Higgins, John R.; Burke, Gerald; Higgins, Shane; Tully, Elizabeth; Carroll, Stephen; Malone, Fergal D.

doi:10.3109/14767058.2013.818653

Cited by 23 publications

(26 citation statements)

References 20 publications

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“…No significant difference was observed considering neonatal weight and the prevalence of low birth weight (LBW) between groups (p=0.72 for first twin, p=0.94 for second twin). This is in line with many previous studies ( 6 , 11 ). Nevertheless, three other studies found lower mean neonatal weight and higher rate of LBW in ART group compared to spontaneous group.…”

Section: Discussionsupporting

confidence: 94%

“…However, the study of Anbazhaqan et al showed no significant difference in pregnancy complications and perinatal mortality between twin pregnancy following ART and spontaneous pregnancy ( 6 ). In a retrospective study by Geisler and colleagues maternal and neonatal outcomes of ART conceived and spontaneously conceived twin pregnancy were compared.…”

Section: Introductionmentioning

confidence: 97%

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Obstetrics and perinatal outcomes of dichorionic twin pregnancy following ART compared with spontaneous pregnancy

Pourali

Ayati

Jelodar

et al. 2016

IJRM

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Introduction:Regarding to the recent advances in assisted reproductive techniques (ART), twin and multiple pregnancies have increased during past years. Objective:This study was performed to compare obstetrics and perinatal outcomes of dichorionic twin pregnancy following ART with spontaneous pregnancy. Materials and Methods:In this cross-sectional study which was performed in Ghaem Hospital, Mashhad University of Medical Sciences, 107 dichorionic twin pregnancy were enrolled in two groups: spontaneous group (n=96) and ART group (n=31). Basic criteria and obstetrics and neonatal outcomes information including demographic data, gestational age, mode of delivery, pregnancy complications (preeclampsia, gestational diabetes, preterm labor, and intrauterine growth retardation (IUGR), postpartum hemorrhage), neonatal outcomes (weight, first and fifth minute Apgar score, Neonatal Intensive Care Unit (NICU) admission, mortality, respiratory distress, and icterus) were recorded using a questionnaire.Results:Preterm labor, gestational diabetes, and preeclampsia were significantly higher in ART group compared to spontaneous pregnancy group. However, other factors such as anemia, IUGR, postpartum hemorrhage, and intrauterine fetal death (IUFD) were not significantly different between groups. There were no significant differences between groups in terms of neonatal outcomes (weight, 1st and 5th min Apgar score <7, NICU hospitalization, mortality, respiratory distress, and icterus). Conclusion:With regard of significantly higher poor outcomes such as preeclampsia, gestational diabetes and preterm labor in ART group, the couples should be aware of these potential risks before choosing ART.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 97%

Obstetrics and perinatal outcomes of dichorionic twin pregnancy following ART compared with spontaneous pregnancy

Pourali

Ayati

Jelodar

et al. 2016

IJRM

View full text Add to dashboard Cite

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“…In general, most studies show little difference in perinatal outcomes in spontaneously-conceived and subfertile or IVF twins, partially due to failure to control for monozygosity and monochorionicity (16, 49, 55–57). Two-thirds of twins are dizygotic, with 50% being like gender and 50% unlike gender.…”

Section: Discussionmentioning

confidence: 99%

Adverse pregnancy, birth, and infant outcomes in twins: effects of maternal fertility status and infant gender combinations; the Massachusetts Outcomes Study of Assisted Reproductive Technology

Luke

Gopal

Cabral

et al. 2017

American Journal of Obstetrics and Gynecology

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Background It is unknown whether the risk of adverse outcomes in twin pregnancies among subfertile women, conceived with and without in vitro fertilization (IVF), differ from those conceived spontaneously. Objective To evaluate the effects of fertility status on adverse perinatal outcomes in twin pregnancies on a population basis. Study Design All twin live births of ≥22 weeks’ gestation and ≥350 grams birthweight to Massachusetts resident women in 2004–10 were linked to hospital discharge records, vital records, and IVF cycles. Women were categorized by their fertility status as in vitro fertilization (IVF), subfertile, or fertile, and by twin pair genders (all, like, unlike). Women whose births linked to IVF cycles were classified as IVF; those with indicators of subfertility but without IVF treatment were classified as subfertile; all others were classified as fertile. Risks of six adverse pregnancy outcomes (gestational diabetes, pregnancy hypertension, uterine bleeding, placental complications (placenta abruptio, placenta previa, and vasa previa), prenatal hospitalizations, primary cesarean), and nine adverse infant outcomes (very low birthweight, low birthweight, small-for-gestation birthweight, large-for-gestation birthweight, very preterm (<32 weeks), preterm, birth defects, neonatal death, and infant death) were modeled by fertility status with the fertile group as reference, using multivariate log binomial regression and reported as adjusted relative risk ratios (ARRs) and 95% confidence intervals (CI). Results The study population included 10,352 women with twin pregnancies (6,090 fertile, 724 subfertile, and 3,538 IVF). Among all twins, the risks for all six adverse pregnancy outcomes were significantly increased for the subfertile and IVF groups, with highest risks for uterine bleeding (ARR 1.92, 2.58, respectively), and placental complications (ARR 2.07and 1.83, respectively). Among all twins, the risks for those born to subfertile women were significantly increased for very preterm birth, and neonatal and infant death (ARR 1.36, 1.89, and 1.87, respectively); risks were significantly increased among IVF twins for very preterm birth, preterm birth, and birth defects (ARR 1.28, 1.07, and 1.26, respectively). Conclusions Risks of all maternal and most infant adverse outcomes are increased for subfertile and IVF twins. Among all twins, the highest risks were for uterine bleeding and placental complications for the subfertile and IVF groups, and neonatal and infant death in the subfertile group. These findings provide further evidence supporting single embryo transfer and more cautious use of ovulation induction.

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“…Adverse obstetric outcome after ART might be caused by the very procedure 4 . Moreover, ART conceived twins can be at even higher risk of pregnancy complications and adverse obstetric outcomes due to maternal age, pre-existing maternal medical conditions such as polycystic ovary syndrome or thyroid diseases that are associated with miscarriages and aneuploidies [7][8][9] .…”

Section: Discussionmentioning

confidence: 99%

Twin pregnancies concieved by assisted reproduction - early prediction of preterm birth

et al. 2020

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Background/Aim. Twins conceived by assisted reproduction techniques (ART) are the most susceptible for perinatal complications. The aim of this study was to examine the role of prenatal noninvasive fetal screening of the first and second trimester in prediction of delivery time of ART conceived twins. Methods. Prospective cohort study of all ART conceived twin pregnancies was conducted at the Clinic for Obstetrics and Gynecology, Clinical Center of Serbia, during the period from January 1, 2016 to December 31, 2017. In the 12th gestational week (GW) twins crown-rump lenght (CRL) and thickness nuchal translucency (NT) were measured ultrasonographically. Moreover, serum levels of beta subunit of human chorionic gonadotropin (β hCG) and pregnancy-associated plasma protein A (PAPPA) were assessed. In the 17th GW twins biparietal diameter (BPD), abdominal circumference (AC) and femur length (FL) were determined ultrasonografically. Additionally, β hCG, alphafetoprotein (AFP), estriol (E3) and inhibin (INH) were measured in mothers serum. The GW of delivery was noted for each pregnancy. Results. Study included 100 pregnant women with mean age 35.44 ± 5.82. In the examined sample of ART conceived twins significantly more (51%) were delivered in term (≥ 35 GW) (p = 0.001). Delivery time correlated negatively with NT and first trimester β hCG serum levels, while it correlated positively with FL of the smaller twin, second trimester β hCG, AFP and E3 concentrations. According to obtained model for prediction of delivery time in ART conceived twin pregnancies based on first trimester diagnostic tests the significant predictors were PAPPA and β hCG in the 12th GW as well as NT of the first larger twin. Nevertheless, reliability (sensitivity 50%-75%, specificity 30%-40%) of these diagnostic tests was moderate. Conclusion. Prenatal noninvasive fetal screening of the first and second trimester (ultrasonography and laboratory testing) can be used for prediction of delivery time of ART conceived twins. ApstraktUvod/Cilj. Blizanci nastali tehnikama asistirane reprodukcije (ART) su najosetljiviji na pojavu perinatalnih komplikacija. Cilj rada bio je da se ispita uloga prenatalnog neinvazivnog fetalnog skrininga prvog i drugog trimestra u predviđanju vremena porođaja blizanaca nastalih metodama ART. Metode. Prospektivna kohortna studija kojom su obuhvaćene sve blizanačke trudnoće nastale ART metodama sprovedena je na Klinici za ginekologiju i akušerstvo Kliničkog centra Srbije u periodu od 01. 01.2016. do 31.12.2017. U 12. gestacionoj nedelji (GN) ultrasonografski su blizancima izmereni razmak teme-trtica (CRL) i nuhalno zadebljanje (NT). Takođe, određeni su serumski nivoi beta podjedinice humanog horionskog gonadotropina (β hCG) i plazma proteina A povezanog sa trudnocćom (PAPPA). U 17. GN ultrasonografski su blizancima izmereni biparietalni dijametar (BPD), obim abdomena (AC) i dužine femura (FL). Pored toga, β hCG, alfa fetoprotein (AFP), estriol (E3) i inhibin (INH) su izmereni u serumu majki. Za svaku trudnocú zabeležena je G...

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Comparison of outcomes of twins conceived spontaneously and by artificial reproductive therapy

Abstract: There were no differences in the rate of adverse obstetric or perinatal outcomes between twins conceived naturally compared with twins conceived by assisted conception.

Cited by 23 publications

References 20 publications

Obstetrics and perinatal outcomes of dichorionic twin pregnancy following ART compared with spontaneous pregnancy

Obstetrics and perinatal outcomes of dichorionic twin pregnancy following ART compared with spontaneous pregnancy

Adverse pregnancy, birth, and infant outcomes in twins: effects of maternal fertility status and infant gender combinations; the Massachusetts Outcomes Study of Assisted Reproductive Technology

Twin pregnancies concieved by assisted reproduction - early prediction of preterm birth

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