Comparison of Overall Obesity and Body Fat Distribution in Predicting Risk of Mortality

Reis, Jared P.; Macera, Caroline A.; Araneta, Maria Rosario G.; Lindsay, Suzanne P.; Marshall, Simon; Wingard, Deborah L.

doi:10.1038/oby.2008.664

Cited by 134 publications

(141 citation statements)

References 37 publications

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“…These findings suggest that defining obesity on the base of WC, HC, or WHR may be equally valid and useful methods for use in epidemiological research and clinical practice. Our results are in agreement with another study identified a high correlation between WC and BMI and suggested this could imply that WC is not only an indicator of abdominal adiposity but also overall obesity (Reis et al 2009). However, other studies have suggested that WHR to be a better predicator of CVD risk (Bigaard et al 2004).…”

Section: Discussionsupporting

confidence: 83%

Prevalence of obesity, central obesity, and associated socio-demographic variables in Syrian women using different anthropometric indicators

Bakir

Hammad

Mohammad

2017

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The prevalence of overweight and obesity is increasing globally in both developing and developed countries, especially, those with rapid cultural and social changes. The aims of current study were twofold: (a) to examine, for the first time in Syria, the prevalence of overweight, obesity and central obesity in Syrian women and obesity-related socio-demographic determinants, and (b) to establish a base line data about obesity related determinants needed to develop appropriate treatment and prevention strategies. Cross-sectional study with a randomly representative sample of 923 women aged 18-60 years was conducted. Waist (WC) and hip circumference (HC) were measured, and body mass index (BMI) waist-to-hip ratio (WHR) were calculated. Socio-demographic data were collected with a designed questionnaire. The overall prevalence of overweight and obesity in Syrian women as defined by BMI were 31% and 43%, respectively. The overall central obesity as defined by WC and WHR were 53% and 33%, respectively. The prevalence of obesity and central obesity were increased with age. WC and HC were strongly correlated with BMI. The mean BMIs and other anthropometric measurements were significantly higher in married, house wife, less educated, high parity, and low physical activity women. The results of this study indicate an increased rates of overweight, overall, and central obesity in Syrian women. Also, central obesity as defined by WC is higher than BMI derived obesity. In conclusion, WC is more appropriate to be used for obesity assessment, where, BMI underestimates the obesity prevalence among middle-age women. Development of appropriate treatment and prevention strategies are urgently needed to combat with increasing rate of obesity among Syrian women.

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Section: Discussionsupporting

confidence: 83%

Prevalence of obesity, central obesity, and associated socio-demographic variables in Syrian women using different anthropometric indicators

Bakir

Hammad

Mohammad

2017

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“…Higher body mass index (BMI) in older people is associated with higher survival rates, in contrast to middle-aged people (Adams et al 2006;Al Snih et al 2007;Reis et al 2009;Auyeung et al 2010;Janssen 2007;Tamakoshi et al 2010). This has led to the postulation that obesity might be less harmful or even protective in old age (Al Snih et al 2007;Reis et al 2009;Auyeung et al 2010;Lea et al 2009).…”

Section: Introductionmentioning

confidence: 99%

“…This has led to the postulation that obesity might be less harmful or even protective in old age (Al Snih et al 2007;Reis et al 2009;Auyeung et al 2010;Lea et al 2009). Yet, BMI is a measure of overall adiposity, which makes no distinction between fat elsewhere and abdominal fat, the latter being metabolically more harmful (Lapidus et al 1994;Chang et al 2000;Snijder et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Survival benefit of abdominal adiposity: a 6-year follow-up study with Dual X-ray absorptiometry in 3,978 older adults

Lee

Auyeung

Kwok

et al. 2011

AGE

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In contrast to that in the middle-aged, higher body mass index (BMI) in older people is associated with higher survival rates. Yet, BMI makes no distinction between fat elsewhere and abdominal fat, the latter being metabolically more harmful. We hypothesized that overall adiposity might be protective in old age, but that central fat might offset that benefit and remained harmful as in the middle-aged. Three thousand nine hundred seventy-eight Chinese elderly ≥65 years had demographics, medical conditions, physical activity, and body composition by DXA recorded at baseline. Overall adiposity was measured as whole body fat%, and abdominal adiposity as waist circumference, waisthip ratio, and relative abdominal fat (RAF) (relative abdominal fat = abdominal fat according to anatomical landmarks/whole body fat). Deaths within 1 year from baseline were excluded from analysis. All-cause and cardiovascular mortality were analyzed using Cox regression, adjusted for covariates. The lowest quintile of adiposity measurements was used for comparison. After a mean follow-up of 72.3 months, 13.7% men and 4.5% women had died. In men, the highest two quintiles of whole body fat % and the upper four quintiles of RAF were associated with significantly lower all-cause mortality, and adjusted hazard ratio (95% CI) in ascending quintiles of RAF compared with the lowest quintile was 0.62 (0.43-0.89), 0.58 (0.4-0.85), 0.52 (0.36-0.77), and 0.67 (0.47-0.96). No relationship was found between abdominal adiposity and cardiovascular mortality in both genders. Higher whole body fat % as well as higher proportion of abdominal fat was associated with lower all-cause mortality in men. No such relation was found in women.

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“…Increased abdominal adiposity is associated with adverse cardiovascular outcomes (Berg and Scherer 2005) and was also repeatedly related to impaired lung function (Leone et al 2009;OchsBalcom et al 2006;Wehrmeister et al 2012). In studies relying on waist-to-hip ratio, waist circumference, or imaging techniques as markers of intra-abdominal fat tissue, higher abdominal fat mass was most often associated with increased overall mortality (Bigaard et al 2005;Reis et al 2009;Zhang et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Common SIRT1 variants modify the effect of abdominal adipose tissue on aging-related lung function decline

Ivan

Imboden

Bridevaux

et al. 2016

AGE

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Lung function is an independent predictor of mortality and serves as an aging marker in never smokers. The protein sirtuin-1 of gene SIRT1 has profound anti-inflammatory effects and regulates metabolic pathways. Its suggested longevity effects on lower organisms remain poorly studied in humans. In 1132 never smokers of the population-based SAPALDIA cohort, we investigated associations between single nucleotide polymorphisms (SNPs; rs730821, rs10997868, rs10823116) of SIRT1 and aging-related lung function decline over 11 years in terms of change in forced expiratory volume in the first second (FEV 1 ), forced vital capacity (FVC), FEV 1 /FVC ratio, and forced expiratory flow between 25 and 75 % of FVC ) using multiple linear regression models. Interactions between the SIRT1 SNPs and adiposity parameters (body mass index (BMI), its change and weight gain) were tested by including multiplicative interaction terms into the models. SIRT1 polymorphisms exhibited no main effects, but modified the association between obesity measures and FEV 1 /FVC and FEF was accelerated up to −0.5 % (95 % CI −1.0 to 0 %) and −0.7 % (−1.3 to −0.2 %) over interquartile range increases in BMI (2.4 kg/m 2 ) or weight (6.5 kg), respectively. For FEF decline, corresponding estimates were −57 mL/s (−117 to 4 mL/s) and −76 mL/s (−1429 to −9 mL/s). Interactions were not present in participants with genetically lowered C-reactive protein concentrations. Genetic variation in SIRT1 might therefore affect lung function and human longevity by modifying subclinical inflammation arising from abdominal adipose tissue.

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Comparison of Overall Obesity and Body Fat Distribution in Predicting Risk of Mortality

Cited by 134 publications

References 37 publications

Prevalence of obesity, central obesity, and associated socio-demographic variables in Syrian women using different anthropometric indicators

Prevalence of obesity, central obesity, and associated socio-demographic variables in Syrian women using different anthropometric indicators

Survival benefit of abdominal adiposity: a 6-year follow-up study with Dual X-ray absorptiometry in 3,978 older adults

Common SIRT1 variants modify the effect of abdominal adipose tissue on aging-related lung function decline

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