Comparison of oxidative stress-mitochondria-mediated tenderization in two different bovine muscles during aging

Effect of mitochondrial calcium homeostasis-mediated endogenous enzyme activation on tenderness of beef muscle based on MCU modulators

“…5 B, C). Additionally, the caspase-9 and caspase-3 activities of the Ru360 group reached their maximum values at 24 h and 72 h PM, respectively, which is consistent with our previous results ( Ding et al, 2022 ; Wang et al, 2017 ). The impact of the spermine/Ru360 treatment on caspase-9 and caspase-3 activities was dependent on time (treatment × time, P < 0.001).…”

“…The amount of mitochondrial ROS fell from 0 to 12 h and rose from 12 to 120 h ( P < 0.05) in the control group. Previous studies revealed that the ROS level in muscle first decreased and then increased, reaching its lowest point at 6 h or 12 h ( Ding et al, 2022 ; Zhang, Li, Yu, Han, & Ma, 2019 ). The mitochondrial ROS level at 24 h in longissimus lumborum was higher than that at 1 h PM ( Zou et al, 2022 ).…”

“…Analogously, mitochondria-induced apoptosis is primarily due to mitochondrial dysfunction and redox homeostasis imbalance ( Ma, Zhang, Wang, Yu, & Han, 2023 ). The primary organelle that produces reactive oxygen species (ROS) is the mitochondria, which is also the organelle that is most frequently targeted for attack ( Ding, Wei, Liu, Zhang, & Huang, 2022 ). ROS generated by single electron transfer could result in mitochondrial membrane swelling or loss of membrane potential after animal bleeding ( Liu et al, 2023 ; Zhang, Ma, & Kim, 2020 ).…”