Comparison of parametric imaging and SUV imaging with [68 Ga]Ga-PSMA-11 using dynamic total-body PET/CT in prostate cancer

Chen, Ruohua; Ng, Yee Ling; Yang, Xinlan; Zhu, Yinjie; Li, Lianghua; Zhao, Haitao; Zhou, Yun; Huang, Gang; Liu, Jianjun

doi:10.1007/s00259-023-06456-1

Cited by 12 publications

(6 citation statements)

References 35 publications

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“…The reliability increases with increasing the extended time interval between the DTP, agreed with the findings of Wu et al [16]. The image contrast of 60-min parametric Ki images illustrated an improved qualitative assessment, exhibiting a 1.49-fold improvement in lesion-to-muscle ratios compared to SUV images, which were consistent with findings reported in earlier studies [28,31]. The muscle Ki values in the 10-min parametric Ki images were inspected to be lower than those in the 5-min parametric Ki images, influencing the enhancement of LBRs in the 10-min parametric Ki images.…”

Section: Discussionsupporting

confidence: 91%

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Dual-time-point (DTP) dynamic 68Ga-PSMA-11 PET/CT for parametric imaging generation in prostate cancer

Burasothikul,

Navikhacheevin,

Pasawang

et al. 2024

Preprint

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Purpose: To investigate the optimal dual-time-point (DTP) approaches using dynamic 68Ga-PSMA-11 PET/CT imaging to generate parametric images for patients diagnosed with prostate cancer. Methods: Fifteen prostate cancer patients were intravenously administered 68Ga-PSMA-11 of 181.9 ± 47.2 MBq, and immediately acquired a 60-min dynamic PET/CT scan. List-mode data were reconstructed into 25 time-frames: 6 × 10 s, 8 × 30 s, 11 × 300 s, and were corrected for motion and partial volume effect. The DTP parametric imaging was generated using different interval time points of 5 min and 10 min, separated by a minimum time interval of 30 min. Net influx rates (Ki) were calculated through the fitting of a single irreversible two-tissue compartmental model. Intraclass correlation coefficient (ICC) values between DTP protocols and 60-min Ki were calculated. Lesion-to-background ratios (LBRs) of Ki images and standardized uptake value (SUV) images in each DTP protocol were determined. Results: The DTP protocol of 5-10 min with 40-45 min showed the highest ICC of 0.988 compared to the 60-min Ki whereas the ICC values for the 0-5 min with 55-60 min and 0-10 min with 50-60 min intervals were 0.941. The LBRs of 60-min Ki, 5-10 min with 40-45 min Ki, 0-5 min with 55-60 min Ki, 0-10 min with 50-60 min Ki, SUVmean, and SUVmax images were 29.53 ± 27.33, 13.05 ± 15.28, 45.15 ± 53.11, 45.52 ± 70.31, 19.77 ± 23.43, and 25.06 ± 30.07, respectively. Conclusions: The optimal DTP parametric imaging achieves a comparable Ki to 60-min parametric imaging and exhibits remarkable image quality and contrast compared to SUV imaging, enhancing prostate cancer diagnosis while maintaining time efficiency.

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Section: Discussionsupporting

confidence: 91%

“…The delineation of 3D ROIs was performed over the muscular area to extract Ki for background regions from both of the 60-min parametric Ki images and the DTP parametric Ki images [28]. The LBRs were quantified utilizing the following formula:…”

Section: Image Analysismentioning

confidence: 99%

Dual-time-point (DTP) dynamic 68Ga-PSMA-11 PET/CT for parametric imaging generation in prostate cancer

Burasothikul,

Navikhacheevin,

Pasawang

et al. 2024

Preprint

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“…Owing to its high sensitivity, resolution, and complete coverage of all organs, TB-PET not only produces superior images [2][3][4] with reduced radiation doses [7,14,16,17,20,54] and scan times [5,6,8,9] but also enables the transformation of PET from traditional single-parameter imaging to multi-parameter imaging [39,42,[47][48][49][50]52]. Previously impossible, TB-PET enables the determination of radiotracer kinetics and distribution across multiple organs, which facilitates the elucidation of interrelationships among physiological/pathological factors influencing the distribution of specific radiotracers between organs [1,11,26,41,55].…”

Section: Perspectivementioning

confidence: 99%

“…This discovery indicates that k 3 holds promise as a prospective imaging biomarker for distinguishing between pathologic and non‐specific 68 Ga‐PSMA‐11 uptake in patients with prostate cancer. Parametric imaging with 68 Ga‐PSMA‐11 TB‐PET enhances lesion contrast and improves lesion detectability compared with SUV imaging [48] (Figure 5). This may potentially serve as an imaging biomarker and theranostic tool for precise diagnosis and treatment evaluation of patients with prostate cancer.…”

Section: Current Clinical Applicationsmentioning

confidence: 99%

“…Non-FDG tracers have been used for parametric imaging with TB-PET [48][49][50][51]. Chen et al found that the kinetics of 68 Ga-PSMA-11 in patients with prostate cancer is well described by the irreversible two-tissue compartment model (2T3k) model, and the quality of parametric imaging, namely high sensitivity and low noise, meets clinical diagnostic needs [52].…”

Section: Parametric Imagingmentioning

confidence: 99%

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Current progress and future perspectives in total‐body positron emission tomography/computed tomography. Part II: Clinical applications

Chen,

Sun,

Huang

et al. 2024

iRADIOLOGY

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Total‐body positron emission tomography (TB‐PET) has significantly advanced from initial conception to global commercial availability. The high sensitivity of TB‐PET has led to superior lesion detection, thereby expanding the range of clinical applications. TB‐PET technology offers several advantages: (a) It enables the detection of small lesions, facilitating precise cancer staging and targeted cancer formulation. (b) The technology shortens the acquisition time while maintaining the quality of diagnostic images. (c) TB‐PET allows for a reduction in the amount of administered radiotracer, which minimizes image noise, reduces the effective radiation dose to patients, and enhances staff safety. (d) The scanner supports the development of new tracers and the dynamic imaging of these tracers throughout the entire body. (e) TB‐PET accommodates delayed scanning, which has been shown to improve the detection of small and previously undetected malignant lesions by enhancing the clearance in areas of significant background activity. (f) Owing to its high‐quality images, TB‐PET is suitable for parametric imaging, which offers several advantages over conventional standardized uptake value imaging. However, TB‐PET still faces several challenges. There is a lack of consensus on the optimal dose and scan duration for clinical diagnosis using TB‐PET. Additionally, unified standards for parametric imaging via TB‐PET are yet to be established, and the full clinical significance of this technology remains under‐explored. The accompanying review (Part 1) covers TB‐PET data manipulation and analysis.

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Total-body dynamic PET/CT imaging reveals kinetic distribution of [13N]NH3 in normal organs

Liu,

Gu,

Chen

et al. 2024

Eur J Nucl Med Mol Imaging

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Comparison of parametric imaging and SUV imaging with [68 Ga]Ga-PSMA-11 using dynamic total-body PET/CT in prostate cancer

Cited by 12 publications

References 35 publications

Dual-time-point (DTP) dynamic 68Ga-PSMA-11 PET/CT for parametric imaging generation in prostate cancer

Dual-time-point (DTP) dynamic 68Ga-PSMA-11 PET/CT for parametric imaging generation in prostate cancer

Current progress and future perspectives in total‐body positron emission tomography/computed tomography. Part II: Clinical applications

Total-body dynamic PET/CT imaging reveals kinetic distribution of [13N]NH3 in normal organs

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