Comparison of Parkinson’s Disease Patients’ Characteristics by Indication
                        for Deep Brain Stimulation: Men Are More Likely to Have DBS for
                        Tremor

Dalrymple, W. Alex; Pusso, Antonia; Sperling, Scott A.; Flanigan, Joseph L.; Huss, Diane; Harrison, Madaline B.; Elias, W. Jeffrey; Shah, Binit

doi:10.5334/tohm.468

Cited by 5 publications

(6 citation statements)

References 13 publications

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“…Of the 1,162 initially screened studies, 13 met inclusion criteria (Fig. 1; Table 1) [6][7][8][9][10][11][12][13][14][15][16][17]22], with publication years spanning 2014-2023. Studies originated from 5 different countries, with 8 (66.7%) from the USA.…”

Section: Article Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Disparities in Access to Deep Brain Stimulation for Parkinson’s Disease and Proposed Interventions: A Literature Review

Bishay,

Hughes,

Zargari

et al. 2024

Stereotact Funct Neurosurg

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Background: Deep brain stimulation (DBS) is an effective therapy for Parkinson’s disease (PD), but disparities exist in access to DBS along gender, racial, and socioeconomic lines. Summary: Women are underrepresented in clinical trials and less likely to undergo DBS compared to their male counterparts. Racial and ethnic minorities are also less likely to undergo DBS procedures, even when controlling for disease severity and other demographic factors. These disparities can have significant impacts on patients’ access to care, quality of life, and ability to manage their debilitating movement disorders. Key Messages: Addressing these disparities requires increasing patient awareness and education, minimizing barriers to equitable access, and implementing diversity and inclusion initiatives within the healthcare system. In this systematic review, we first review literature discussing gender, racial, and socioeconomic disparities in DBS access and then propose several patient, provider, community, and national-level interventions to improve DBS access for all populations.

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Section: Article Characteristicsmentioning

confidence: 99%

“…These steps are also areas to target with interventions to reduce disparities. Previous studies have shown differences in patient access to DBS based on race, socioeconomic status, and gender [6][7][8][9][10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Disparities in Access to Deep Brain Stimulation for Parkinson’s Disease and Proposed Interventions: A Literature Review

Bishay,

Hughes,

Zargari

et al. 2024

Stereotact Funct Neurosurg

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show abstract

“…DBS STN is twice more common in men and women are still strongly under-represented for DBS consideration. Also, patients who underwent DBS for medication refractory tremor were predominantly men [34,35]. Sex specific influence has been established in regard to selection and outcome of deep brain stimulation for PD.…”

Section: Deep Brain Stimulationmentioning

confidence: 99%

Sex Differences in the Therapy of Advanced Movement Disorders

Vuletić

2023

Arch. Psychiatry Res.

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The influence of sex differences in movement disorders is still under-recognized. There are significant sex differences in the pathophysiology, epidemiology, clinical manifestations, and treatments outcome of many of movement disorders especially Parkinson’s disease. Importance of sex specific differences in invasive treatment outcomes emphasize the importance of their considering when devising patient’s individual management strategies. Increased recognition and future prospective studies specifically addressing sex differences in invasive treatments’ outcomes may help and provide a tailored therapeutic and precision medicine approach to movement disorders. We highlight the most relevant invasive treatment’s effects in advanced movement disorders that differ between men and women. But also, the differences in selection of invasive methods. Increased recognition of sex differences and their impact on treatment of advanced phase of movement disorders, that are very disabling, is very important for future studies and precise and personalized medicine. In this article, we provide a review of sex- related differences in treatment of advanced movement disorders, mostly Parkinson’s diseases.

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“…It has been postulated that women may be risk averse with regard to surgical intervention such as DBS. However, more research is needed to further corroborate this and to elucidate whether women may be more risk averse to experimental pharmacological and surgical trials as well 102 …”

Section: Gaps and Controversiesmentioning

confidence: 99%

“…However, more research is needed to further corroborate this and to elucidate whether women may be more risk averse to experimental pharmacological and surgical trials as well. 102 More than 10 years ago, a call was launched for improved clinical studies and comparative effectiveness research to include women with PD. 103 Only recently have funding organizations such as the European Commission, the Canadian Institutes of Health Research, and the U.S. National Institutes of Health made efforts to influence researchers to integrate sex and gender focus into the entire study pipeline from hypothesis to publication.…”

Section: Engagement Of Women In Researchmentioning

confidence: 99%

Unmet Needs of Women Living with Parkinson's Disease: Gaps and Controversies

Subramanian

Mathur²,

Oosterbaan

et al. 2022

Movement Disorders

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A BS TRACT: Personalized medicine considering sex, gender, and cultural context has become the vanguard of delivery of care. However, women's issues in Parkinson disease (PD), especially from a psychosocial standpoint, have been an overlooked field. The key research areas include women-inclusive drug and device studies and genetic and hormonal considerations. Moreover, women with PD need to be educated and empowered on how to communicate their symptoms and needs, get engaged in research, get organized as a community, and support one another. Women with PD need tools to help track and convey their unique motor and nonmotor symptoms and psychological and social support needs. The management of PD needs to be customized to include the unique stages of women's lives, including menstrual cycles, pregnancy, perimenopause, menopause, and postmenopause. Specific guidelines for the use of hormonal treatments and customized dopamine replacement dosing need to be developed. Women need guidance on culturally sensitive wellness and selfcare strategies that are customized for them. Basic core competencies in knowledge for all clinicians treating women with PD need to be established, including how to accurately diagnose, proactively identify, and treat the symptoms of PD in women and to ensure timely referral for specialty care, advanced therapies, and research studies. Caregivers and families need guidance on holistically supporting women with PD. The voices of women living with PD must be amplified to catalyze real change in this neglected field. This paper provides an overview of the current knowledge, gaps, and possible strategies to deal with the unmet needs of women living with PD with a focus on the clinical and psychosocial aspects.

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Comparison of Parkinson’s Disease Patients’ Characteristics by Indication for Deep Brain Stimulation: Men Are More Likely to Have DBS for Tremor

Cited by 5 publications

References 13 publications

Disparities in Access to Deep Brain Stimulation for Parkinson’s Disease and Proposed Interventions: A Literature Review

Disparities in Access to Deep Brain Stimulation for Parkinson’s Disease and Proposed Interventions: A Literature Review

Sex Differences in the Therapy of Advanced Movement Disorders

Unmet Needs of Women Living with Parkinson's Disease: Gaps and Controversies

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