Comparison of patient-controlled analgesia with and without dexmedetomidine following spine surgery in children

Sadhasivam, Senthilkumar; Boat, Anne Christine; Mahmoud, Mohamed

doi:10.1016/j.jclinane.2008.12.017

Cited by 43 publications

(20 citation statements)

References 25 publications

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“…Owing to unpredictable large inter-patient variability in responses and narrow therapeutic indices of the drug, postoperative pain relief remains suboptimal and central side effects like respiratory depression occur often (up to 41% incidence) in postsurgical patients. 1–3 In fact, 50% of postoperative respiratory failure events involve patients receiving opioids. 4,5 Respiratory depression could potentially lead to hypoxic brain injury and fatality.…”

Section: Introductionmentioning

confidence: 99%

Association of OPRM1 A118G variant with risk of morphine-induced respiratory depression following spine fusion in adolescents

et al. 2014

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The μ1 opioid receptor (OPRM1) genetic variant A118G results in decreased μ-receptor binding potential in the brain and increases morphine requirement. We hypothesized that OPRM1 A118G polymorphism will affect morphine-induced respiratory depression (MIRD) risk in children receiving morphine. A prospective genotype-blinded study was conducted in 88 healthy adolescents (11–18 years; 67% female, 85% Caucasian) who underwent spine fusion for scoliosis. They were followed for 48 h postoperatively for MIRD, pain scores, morphine consumption and use of analgesic adjuvants. Patients were genotyped for OPRM1 A118G variant—76% were wild type (AA) and 24% heterozygous/homozygous for variant (AG/GG). Multivariable logistic regression showed that the risk of MIRD in patients with AA genotype was significantly higher (odds ratio 5.6, 95% CI: 1.4–37.2, P = 0.030). Presence of G allele was associated with higher pain scores (effect size 0.73, P = 0.045). This novel association is an important step toward predicting MIRD susceptibility and personalizing morphine use.

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Section: Introductionmentioning

confidence: 99%

Association of OPRM1 A118G variant with risk of morphine-induced respiratory depression following spine fusion in adolescents

et al. 2014

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“…They found out that post-operative 24-hour DEX infusion as an adjunct to PCIA with opioids might have a morphine-sparing effect as evidenced by the increase in morphine use on postoperative two days after the DEX infusion was stopped (19).…”

Section: Discussionmentioning

confidence: 99%

The Analgesic Effect of Morphine and Dexmedetomidine Intravenous Patient-Controlled Analgesia method to Control Pain After Open Cardiac Surgery: A Randomized Control Trial

Ghandi¹,

Alavi²,

Babaee³

et al. 2015

Arch Crit Care Med

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“…Sadhasivam et al [18] described the possible morphinesparing effect of DEX after spinal fusion. The current study showed no significant effect on opioid requirements with the use of DEX.…”

Section: Discussionmentioning

confidence: 99%

Adjunctive Pain Control Methods Lower Narcotic Use and Pain Scores for Patients With Adolescent Idiopathic Scoliosis Undergoing Posterior Spinal Fusion

et al. 2015

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Comparison of patient-controlled analgesia with and without dexmedetomidine following spine surgery in children

Cited by 43 publications

References 25 publications

Association of OPRM1 A118G variant with risk of morphine-induced respiratory depression following spine fusion in adolescents

Association of OPRM1 A118G variant with risk of morphine-induced respiratory depression following spine fusion in adolescents

The Analgesic Effect of Morphine and Dexmedetomidine Intravenous Patient-Controlled Analgesia method to Control Pain After Open Cardiac Surgery: A Randomized Control Trial

Adjunctive Pain Control Methods Lower Narcotic Use and Pain Scores for Patients With Adolescent Idiopathic Scoliosis Undergoing Posterior Spinal Fusion

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