Comparison of patient (POEM), observer (EASI, SASSAD, TIS) and corneometry measures of emollient effectiveness in children with eczema: findings from the COMET feasibility trial

Ridd, Matthew J; Gaunt, Daisy; Guy, Richard H.; Redmond, Niamh M; Garfield, Kirsty; Hollinghurst, Sandra; Ball, Nicola; Shaw, Lindsay; Purdy, Sarah; Metcalfe, Chris

doi:10.1111/bjd.16475

Cited by 8 publications

(7 citation statements)

References 22 publications

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“…On the other hand, POEM scores did not significantly correlate with EASI scores nor with nocturnal scratching time/number. The result, that there was no significant correlation between POEM and EASI scores, is not surprising and is similar to a previous report in children with AD ( 25 ). Interestingly, all 12 cases had the same answer of “itching every day in the previous week” to Question 1 for the POEM, regardless of the severity of their AD.…”

Section: Discussionsupporting

confidence: 92%

Nocturnal Scratching and Quality of Sleep in Children with Atopic Dermatitis

Sugiyama,

Murakami,

Okamoto

et al. 2023

Acta Derm Venereol

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Itching due to atopic dermatitis causes sleep disorders in children, but its pathology is unknown. The aim of this study is to investigate nocturnal scratching as an indirect index of itching during sleep and its relationship with depth of sleep in children with atopic dermatitis. Nocturnal scratching was measured in a total of 20 children with atopic dermatitis, using a smartwatch installed with the application Itch Tracker. Depth of sleep was analysed using polysomnography. The severity of atopic dermatitis was scored using Eczema Area and Severity Index (EASI) and Patient-Oriented Eczema Measure (POEM). The number and time of nocturnal scratching measured by Itch Tracker had a significantly positive correlation with EASI scores, whereas POEM scores were not correlated with EASI scores. Mean sleep efficiency was 90.0% and scratching episodes (n = 67) started mainly during the awake stage or light sleep stages. In the scratching episodes that started during sleep stages (n = 34), the sleep stage changed to a lighter one or to the awake stage in 35.5% of episodes. Itch Tracker is applicable to measure nocturnal scratching in children. Nocturnal scratching can deteriorate quality of sleep by changing the sleep stage to a lighter one or to the awake stage.

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Section: Discussionsupporting

confidence: 92%

Nocturnal Scratching and Quality of Sleep in Children with Atopic Dermatitis

Sugiyama,

Murakami,

Okamoto

et al. 2023

Acta Derm Venereol

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“…Subsequently, the COMET study reported on the feasibility of a trial in primary care comparing four different types of emollients (Aveeno lotion, Diprobase cream, Doublebase gel, Hydromol ointment) in children up to 5 years of age 13. It was not powered to compare the effectiveness of the interventions, but eczema severity improved in all groups over a 12 week period 14. An open-label study1516 randomised 335 children aged 2-6 years with mild to moderate atopic dermatitis to Dexeryl (V0034CR) cream, Atopiclair cream, or no emollient: the proportion of patients with one or more flares and the number of flares was lower in both emollient groups, with Dexeryl cream seeming to perform better than Atopiclair cream.…”

Section: What Is the Evidence Of Uncertainty?mentioning

confidence: 99%

Which emollients are effective and acceptable for eczema in children?

Ridd

Roberts²,

Grindlay

et al. 2019

BMJ

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What you need to know • Although emollients alone can help reduce the symptoms of eczema and prevent flares, most people will need to use anti-inflammatory treatments such as topical corticosteroids of an appropriate strength and duration as well • Effectiveness and acceptability of emollients varies according to disease severity, body site, climate, container, and patient or carer preferences and beliefs • Based on current evidence, the "best" emollient is the one that the individual prefers after a period of testing

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“…78 Un estudio que comparó el cambio en los puntuaciones entre cinco medidas de severidad del eccema -medida de eccema orientada al paciente (POEM), área de eccema e índice de gravedad (EASI), seis áreas, seis signos de dermatitis atópica (SASSAD) e hidratación de la piel (corneometría)-con cuatro tipos de emolientes en niños hasta cinco años de edad durante 12 se-manas concluyó que la severidad del eccema mejoró en todos los grupos con el uso de cualquier emoliente independientemente del tipo de ingredientes y presentación (en crema, loción gel o ungüento). 79 Actualmente está en curso una investigación sobre el uso profiláctico de un emoliente con ceramida en el desarrollo de dermatitis atópica, más allá del periodo de tratamiento activo y el desarrollo de alergias alimentarias y sensibilización alérgica. Los resultados de este ensayo ayudarán a aclarar el papel de la barrera cutánea como una ruta de sensibilización alérgica que desencadena una enfermedad alérgica posterior.…”

Section: Lo Que Dice La Evidencia Científicaunclassified

Emolientes: beneficios, elementos clave y aplicación clínica

Gil-Castaño¹,

Cardona²

2020

RAM

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Los emolientes constituyen la primera línea de manejo para las patologías que afectan la hidratación de la piel entre ellas una de las más importantes la dermatitis atópica; en esta descripción trataremos de hacer un abordaje teórico y práctico que nos permita tomar una decisión adecuada a la hora de formular un emoliente. Inicialmente haremos una descripción aproximada de la barrera epidérmica con sus principales componentes y funciones de los mismos. Posteriormente describiremos las características de una barrera cutánea alterada, los mecanismos para su reparación; continuaremos con la definición de emoliente, mecanismos de hidratación para la recuperación de la barrera, tipos de emolientes, situaciones que debemos tener en cuenta la hora de indicar el uso de los emolientes al igual que la evidencia actual en relación con sus ventajas o no, finalmente indicaremos los puntos clave a la hora en realizar su formulación.

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Comparison of patient (POEM), observer (EASI, SASSAD, TIS) and corneometry measures of emollient effectiveness in children with eczema: findings from the COMET feasibility trial

Abstract: Except for corneometry, all measures appear to change in relation to emollient use over time and correlate well with themselves. POEM demonstrated the greatest range of scores at baseline and change in eczema severity over the first 28 days.

Cited by 8 publications

References 22 publications

Nocturnal Scratching and Quality of Sleep in Children with Atopic Dermatitis

Nocturnal Scratching and Quality of Sleep in Children with Atopic Dermatitis

Which emollients are effective and acceptable for eczema in children?

Emolientes: beneficios, elementos clave y aplicación clínica

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