Comparison of patients' compliance with prescribed oral and inhaled asthma medications

Kelloway, J S

doi:10.1001/archinte.154.12.1349

Cited by 99 publications

(62 citation statements)

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“…Although it was reported that daily dose and administration frequency might influence drug compliance [13,14,15], there were no data in support of this among our patient population. Recently, it was reported that taking LABA, LTRA, and OSRT in combination with ICS may enhance asthma management [23,24,25] and that both prescription of and compliance with these drugs are likely to improve the compliance of ICS themselves [26, 27]. In the present study, however, compliance of OSRT among FPdk users was significantly lower than that in FPdh users.…”

Section: Discussioncontrasting

confidence: 69%

“…In the present study, however, compliance of OSRT among FPdk users was significantly lower than that in FPdh users. Hence, since this result is at variance with previous observations [26, 27], it is difficult to interpret the possible influence of these factors from the available data. On the other hand, better compliance with FPdk could conceivably result in less necessity of OSRT use among FPdk users.…”

Section: Discussioncontrasting

confidence: 55%

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Comparison between Compliance of Fluticasone Propionate Diskhaler and of Fluticasone Propionate Diskus in Adult Bronchial Asthma Patients

Hasegawa

Suzuki²,

Fujimori³

et al. 2006

Respiration

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Background and Objectives: Because inhaled corticosteroids (ICS) play a central role in the management of asthma, new drug delivery systems for fluticasone propionate, Diskhaler (FPdh) and Diskus (FPdk), were developed. However, few studies have focused on compliance with these drug delivery systems, which can influence drug efficacy. Hence, we compared compliance with FPdk versus that with FPdh. Methods:Data were obtained from a survey of pharmacists dispensing anti-asthmatic drugs to adult asthma patients who visited participating pharmacies between October 2002 and November 2003. Patients were limited to regular users of FPdh or FPdk whose medication had not been changed for >6 months before the survey. Compliance and daily administration frequency of ICS were evaluated on the basis of pharmaceutical records. Data on asthma status and various other factors affecting ICS compliance were obtained by questionnaire. Results: Data were acquired on 337 patients. There were no significant differences in gender, age, and duration between the FPdk and FPdh groups. Although FPdk compliance was significantly higher than that of FPdh, conversely there was no significant difference in daily dose and administration frequency between the 2 groups. Furthermore, there was no significant difference in the rate of concomitant drug and in various influencing factors associated with drug compliance. Regarding compliance of concomitant drug, that of oral sustained-released theophylline was significantly lower in FPdk versus FPdh users. Conclusion:In the area of drug compliance, FPdk is superior to FPdh. Although the reason for this is unclear, it is probably due to the characteristics of FPdk itself.

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Section: Discussioncontrasting

confidence: 69%

Section: Discussioncontrasting

confidence: 55%

Comparison between Compliance of Fluticasone Propionate Diskhaler and of Fluticasone Propionate Diskus in Adult Bronchial Asthma Patients

Hasegawa

Suzuki²,

Fujimori³

et al. 2006

Respiration

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“…This phenomenon is common to many chronic diseases like TB, bronchial asthma, rheumatic fever, hypertension, and psychiatric disorders[19,20,21]. A few studies on asthma have shown compliance levels ranging from 11 to 76%[22,23,24,25]. …”

Section: Discussionmentioning

confidence: 99%

Psychotherapy Improves Compliance with Tuberculosis Treatment

et al. 2005

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Background: Low treatment completion rate in tuberculosis (TB) patients is a major concern. Physicians have always been striving for better treatment adherence in such patients. The present study is one such attempt in this direction. Objectives: The study was aimed to evaluate the role of behavior modification by psychotherapy in improving compliance with short-course anti-TB chemotherapy in India. Methods: It was a prospective controlled trial involving patients with confirmed pulmonary and extrapulmonary TB enrolled in the National Tuberculosis Program. The intervention group underwent pretreatment psychological assessment followed by regular psychotherapy sessions. Results: The intervention group had a demographic profile comparable to that of the control group. The patients were mostly from low- and middle-income backgrounds from urban and semi-urban areas. They consistently showed poor knowledge about the nature of the disease, low motivation, and had considerable apprehensions. Following the sessions, the intervention group showed improved compliance compared with the control group, reflected in significantly higher treatment completion and cure rates. Conclusions: The study suggests that psychological intervention is effective in improving compliance with anti-TB treatment, and may reduce the incidence of treatment failure, relapse and drug resistance.

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“…The greater use of oral treatment in North America, including theophyllines, is likely to make a new oral therapy more acceptable there than it would be in Northern and Western Europe, as indeed suggested by a much-quoted study which compared patient compliance with treatment for oral and inhaled therapies. 84 The considerable investment of healthcare professionals in teaching patients how to use appropriate inhalation devices, particularly the very young and the very old, is another factor which is likely to influence the choice of therapy and delivery device. However, the convenience of a once-or twicedaily oral treatment that is targeted to receptors known to be involved in the asthmatic process has certain attractions.…”

Section: Public Perceptionsmentioning

confidence: 99%

Issues and unmet needs in pediatric asthma

Helms

2000

Pediatr. Pulmonol.

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Comparison of patients' compliance with prescribed oral and inhaled asthma medications

Cited by 99 publications

References 0 publications

Comparison between Compliance of Fluticasone Propionate Diskhaler and of Fluticasone Propionate Diskus in Adult Bronchial Asthma Patients

Comparison between Compliance of Fluticasone Propionate Diskhaler and of Fluticasone Propionate Diskus in Adult Bronchial Asthma Patients

Psychotherapy Improves Compliance with Tuberculosis Treatment

Issues and unmet needs in pediatric asthma

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