Comparison of patients with and without digital ulcers in systemic sclerosis: detection of possible risk factors

Sunderkötter, Cord; Herrgott, Ilka; Brückner, Claudia; Moinzadeh, Pia; Pfeiffer, Christiane; Gerß, Joachim; Hunzelmann, Nicolas; Böhm, Markus; Krieg, Thomas; Müller‐Ladner, Ulf; Genth, E.; Schulze-Lohoff, Eckhard; Meurer, Michael; Melchers, Inga; Riemekasten, Gabriela; Centers, Dnss

doi:10.1111/j.1365-2133.2008.09004.x

Cited by 121 publications

(95 citation statements)

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“…A reduction of nailfold capillary density has been observed in PAH patients but it is unknown if this actually precedes or accompanies the development of PAH [9]. The presence of anti-centromere antibodies (ACA) [10], ischemic ulcers of the fingers [11], low diffusing capacity of the lung for carbon monoxide (DL CO ) [12,13], high N-teminal pro-brain natriuretic peptide (NTProBNP) [12,14], and increased numbers of teleangiectases [15] have been associated with the development of SSc-PAH whereas cyclic treatment with iloprost infusion has been reported to be preventive in a preliminary study [16].…”

Section: Introductionmentioning

confidence: 99%

Survival in patients with pulmonary arterial hypertension associated with systemic sclerosis from a Swedish single centre: prognosis still poor and prediction difficult

Hesselstrand

Wildt

Ekmehag

et al. 2010

Scandinavian Journal of Rheumatology

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Section: Introductionmentioning

confidence: 99%

Survival in patients with pulmonary arterial hypertension associated with systemic sclerosis from a Swedish single centre: prognosis still poor and prediction difficult

Hesselstrand

Wildt

Ekmehag

et al. 2010

Scandinavian Journal of Rheumatology

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“…Auch die Lokalisation variiert zwischen den verschiedenen Studien. Einige Studien definieren DUs als nur an der Fingerspitze oder dem Endglied befindlich [10,11], andere wiederum schlossen auch Patienten mit Beteiligung der dorsalen Seite der gesamten Finger ein [12].…”

Section: Klassifikation Und Häufigkeit Digitaler Ulzerationenunclassified

“…Das deutsche Netzwerk für systemische Sklerodermie zeigte bei 1690 untersuchten Patienten eine Prävalenz von 24,1 % für aktive DUs [11].…”

Section: » Schmerzen Waren Bei Fast Allen Digitalen Ulzerationen Vorhunclassified

“…Die höchste Wahrscheinlichkeit für die Entwicklung von DUs wurde im deutschen Netzwerk für systemische Sklerodermie bei männlichen Patienten, frühem Beginn des Raynaud-Syndroms, erhöhter Blutsenkungsgeschwindigkeit, dem Vorhandensein von Scl-70-Antikörpern und Beteiligung des Ösophagus oder pulmonal arteriellen Hypertonie nachgewiesen [11].…”

Section: » Schmerzen Waren Bei Fast Allen Digitalen Ulzerationen Vorhunclassified

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Digitale Ulzerationen bei systemischer Sklerodermie

2014

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Digital ulcers (DU's) are one of the main symptoms of systemic scleroderma and occur in approximately 60% of all scleroderma patients. Due to possible complications such as infections, gangrene or amputation, they require regular medical attention and a good wound treatment by doctors and nursing staff. A definition of DU's has not yet been established. In 2009 the European League Against Rheumatism (EULAR) published guidelines for the treatment of DU's. An improvement of the healing of active ulcers has been described with Iloprost. Bosentan significantly reduced the frequency of occurrence of new DU's. In some small studies PDE-5 inhibitors appear helpful. Further studies with other therapeutic approaches will follow in the next few years.

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“…Bisher waren keine klaren Risikofaktoren für die Entwicklung der digitalen Ulzerationen bekannt, die eine erhebliche Einschränkung der Arbeitsfähigkeit und Lebensqualität der Patienten bedeuten. Hier konnte eine Reihe von Risikofaktoren wie männ-liches Geschlecht, Ausmaß der Hautsklerose, Vorhandensein von Scl-70-Antikör-pern und ein frühes Auftreten eines Raynaud-Phänomens erstmals identifiziert werden [16].…”

Section: Introductionunclassified

Das Deutsche Netzwerk für Systemische Sklerodermie (DNSS)

Hunzelmann

Krieg²,

Dnss³

2012

Hautarzt

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An essential prerequisite for progress in understanding the pathophysiology and the clinical treatment of rare diseases is the national cooperation of specialized centers. The German network for systemic sclerosis (DNSS) is such an interdisciplinary union of hospitals and research centers with a special interest in systemic sclerosis (SSc). A core activity is the patient register of the DNSS which includes over 3,100 patients. It is one of largest national registers of SSc patients worldwide and comprises prospective data on diagnostics as well as primarily therapy of the patients. The register has now proven to be an extremely successful basis for clinical research and basic studies within the framework of international cooperation. The most important results of the cooperation and the register will be presented in this article.

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Comparison of patients with and without digital ulcers in systemic sclerosis: detection of possible risk factors

Abstract: The results reveal possible risk factors for the occurrence of DU in SSc. As DU are prone to local complications, prophylactic vasoactive treatment for patients presenting with these factors may be justified.

Cited by 121 publications

References 20 publications

Survival in patients with pulmonary arterial hypertension associated with systemic sclerosis from a Swedish single centre: prognosis still poor and prediction difficult

Survival in patients with pulmonary arterial hypertension associated with systemic sclerosis from a Swedish single centre: prognosis still poor and prediction difficult

Digitale Ulzerationen bei systemischer Sklerodermie

Das Deutsche Netzwerk für Systemische Sklerodermie (DNSS)

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