Comparison of pediatric patients with status epilepticus lasting 5–29min versus ≥30min

Fernández, Iván Sánchez; Vendrame, Martina; Kapur, Kush; Klehm, Jacqueline; Uysal, Serife; Gedik, Mustafa; An, Sookee; Jillella, Dinesh; Zelener, Jacqueline; Syed, Serajuddaula; Gooty, Vasu; Rotenberg, Alexander; Loddenkemper, Tobias

doi:10.1016/j.yebeh.2014.05.018

Cited by 12 publications

(8 citation statements)

References 13 publications

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“…The EPGP database is unique in its size and the detail of participant phenotyping. The participants with TSE and OSE have characteristics similar to those observed in prior studies, 23,24 and their characteristics are consistent with those reported previously for sex and broad epilepsy class. 25,26 The nature of this cohort broadens the applicability of the findings because EPGP did not selectively enroll families with TSE or OSE, which were not part of the inclusion or exclusion criteria.…”

Section: Discussionsupporting

confidence: 88%

Familial aggregation of status epilepticus in generalized and focal epilepsies

et al. 2020

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ObjectiveTo determine if familial aggregation of status epilepticus (SE) occurs in a large cohort of familial common epilepsies.MethodsWe used the Epilepsy Phenome/Genome Project (EPGP) dataset that consisted of 2,197 participants in 1,043 family units with ≥2 members having a common generalized (GE) or non-acquired focal epilepsy (NAFE). We identified participants with a history of traditionally defined SE (TSE) (seizures ≥30 minutes) and operationally defined SE (OSE) (seizures ≥10 minutes) by chart review. We assessed familial aggregation of TSE and OSE using χ2 analysis and generalized estimating equations (GEE).ResultsOne hundred fifty-five (7%) participants in 1,043 families had ≥1 episode of TSE. Two hundred fifty (11%) had ≥1 episode of OSE. In a χ2 analysis, the number of family units with ≥2 members having TSE (odds ratio [OR] 4.79, 95% CI 2.56–8.97) or OSE (OR 4.23, 95% CI 2.67–6.70) was greater than expected by chance. In GEE models adjusting for sex, broad epilepsy class (GE or NAFE), age at onset, and duration of epilepsy, TSE in a proband predicted TSE in a first-degree relative (OR 2.79, 95% CI 1.24–6.22), and OSE in a proband predicted OSE in a first-degree relative (OR 2.91, 95% CI 1.65–5.15). The results remained significant in models addressing epilepsy severity by incorporating the number of antiseizure medications used or epilepsy surgery.ConclusionsTSE and OSE showed robust familial aggregation in a cohort of familial epilepsy independently of epilepsy severity or class, suggesting that genetic factors contribute to SE independently of the genetic cause of these epilepsies.

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Section: Discussionsupporting

confidence: 88%

Familial aggregation of status epilepticus in generalized and focal epilepsies

et al. 2020

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“…In a population based study, SE duration of greater than 24 h more than doubled the risk of mortality compared with a duration of less than 2 h [10]. It has been shown that for every minute of increase in the duration of SE, the odds ratio of mortality increased by 0.005 [18]. As with mortality, a longer duration of SE may be related to the severity of underlying etiology [19].…”

Section: Duration Of Sementioning

confidence: 99%

Baseline and outcome assessment in pediatric status epilepticus

Jafarpour

Stredny

Piantino

et al. 2019

Seizure

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“…For other SE subtypes, including febrile seizure SE and focal SE with awareness, no duration has been proposed, leaving the older definition of >30 min ( 12 ). This earlier initiation and more aggressive therapeutic approach in the new ILAE definition is based on the knowledge that treatment becomes increasingly difficult the longer a SE lasts, in part due to receptor trafficking such as a reduction of GABA A receptor-mediated inhibition ( 1 , 3 , 14 ).…”

Section: Introductionmentioning

confidence: 99%

Treatment of pediatric convulsive status epilepticus

et al. 2023

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Status epilepticus is one of the most common life-threatening neurological emergencies in childhood with the highest incidence in the first 5 years of life and high mortality and morbidity rates. Although it is known that a delayed treatment and a prolonged seizure can cause permanent brain damage, there is evidence that current treatments may be delayed and the medication doses administered are insufficient. Here, we summarize current knowledge on treatment of convulsive status epilepticus in childhood and propose a treatment algorithm. We performed a structured literature search via PubMed and ClinicalTrails.org and identified 35 prospective and retrospective studies on children <18 years comparing two and more treatment options for status epilepticus. The studies were divided into the commonly used treatment phases. As a first-line treatment, benzodiazepines buccal/rectal/intramuscular/intravenous are recommended. For status epilepticus treated with benzodiazepine refractory, no superiority of fosphenytoin, levetirazetam, or phenobarbital was identified. There is limited data on third-line treatments for refractory status epilepticus lasting >30 min. Our proposed treatment algorithm, especially for children with SE, is for in and out-of-hospital onset aids to promote the establishment and distribution of guidelines to address the treatment delay aggressively and to reduce putative permanent neuronal damage. Further studies are needed to evaluate if these algorithms decrease long-term damage and how to treat refractory status epilepticus lasting >30 min.

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Comparison of pediatric patients with status epilepticus lasting 5–29min versus ≥30min

Cited by 12 publications

References 13 publications

Familial aggregation of status epilepticus in generalized and focal epilepsies

Familial aggregation of status epilepticus in generalized and focal epilepsies

Baseline and outcome assessment in pediatric status epilepticus

Treatment of pediatric convulsive status epilepticus

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