Comparison of performances of various HbA1c methods in Haemoglobin Camperdown variant detection

Gaborit, Bénédicte; Valéro, René; Bégu, Audrey; Vialettes, B.; Nicolay, Alain; Portugal, Henri; Badens, Catherine; Bellanné‐Chantelot, Christine

doi:10.1016/j.cca.2009.01.003

Clinica Chimica Acta

2009

DOI: 10.1016/j.cca.2009.01.003

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Comparison of performances of various HbA1c methods in Haemoglobin Camperdown variant detection

Bénédicte Gaborit¹,

René Valéro²,

Audrey Bégu³

et al.

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“…This interference depends on the type of hemoglobin variant and the method used. Recently, Gaborit et al [ 5 ] published the effects of this variant on HbA 1c measurement using HPLC and immunoassay methods. They concluded that it was not possible to measure the exact HbA 1c value with the affinity chromatography method.…”

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confidence: 99%

Hemoglobin Camperdown [β104Arg→Ser] Detection During Hemoglobin A1c Measurement via Capillary Electrophoresis

et al. 2016

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mentioning

confidence: 99%

Hemoglobin Camperdown [β104Arg→Ser] Detection During Hemoglobin A1c Measurement via Capillary Electrophoresis

et al. 2016

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Comparative evaluation of three different methods for HbA _1c measurement with High-performance liquid chromatography in diabetic patients

Karami

Baradaran

2014

Adv Biomed Res

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Background:The global prevalence of diabetes mellitus is increasing rapidly. Measurement of glycated hemoglobin, predominantly HbA1c, is fundamental to the management of patients with diabetes. HbA1c is used to monitor long-term glycemic control, adjust therapy, assess the quality of diabetes care and predict the risk for the development of complications. While HbA1c is the standard method for long-term glycemic control in diabetic patients, there are different methods for measurement of HbA1c and all laboratories do not use the reference method (high-performance liquid chromatography [HPLC]). The objective of this study is comparison of three different methods with HPLC to find out which method has an acceptable concordance and correlation with the reference method.Materials and Methods:Fifty-eight diabetic patients were assessed in this study. The blood sample of each patient was checked with Diazyme (enzymatic assay), Nycocard (boronate-affinity binding) and Biosystem (micro column chromatography). The values of HbA1c of each method were compared with the Knauer-HPLC results.Results:The means of the differential values between each method and HPLC in the ANOVA test are as follows: M = 1.8, SD = 1.09 for Nycocard-HPLC; M = 1.5, SD = 1.08 for biosystem-HPLC; M = 1.3, SD = 1.2 for Diazyme-HPLC. Pearson's correlation coefficient between HPLC and Nycocard; 0.76, HPLC and Diazyme; 0.75 and between HPLC and Biosystem was 0.68. Linear regression parameters for each method with HPLC were also determined.Conclusion:Diazyme had a better performance and showed a greater concordance with HPLC among others, although it was not an ideal alternative for HPLC.

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Comparison of performances of various HbA1c methods in Haemoglobin Camperdown variant detection

Cited by 2 publications

References 10 publications

Hemoglobin Camperdown [β104Arg→Ser] Detection During Hemoglobin A1c Measurement via Capillary Electrophoresis

Hemoglobin Camperdown [β104Arg→Ser] Detection During Hemoglobin A1c Measurement via Capillary Electrophoresis

Comparative evaluation of three different methods for HbA _1c measurement with High-performance liquid chromatography in diabetic patients

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Comparison of performances of various HbA1c methods in Haemoglobin Camperdown variant detection

Cited by 2 publications

References 10 publications

Hemoglobin Camperdown [β104Arg→Ser] Detection During Hemoglobin A1c Measurement via Capillary Electrophoresis

Hemoglobin Camperdown [β104Arg→Ser] Detection During Hemoglobin A1c Measurement via Capillary Electrophoresis

Comparative evaluation of three different methods for HbA 1c measurement with High-performance liquid chromatography in diabetic patients

Contact Info

Product

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Comparative evaluation of three different methods for HbA _1c measurement with High-performance liquid chromatography in diabetic patients