Comparison of Permethrin-Based Treatment Strategies against Scabies in Infants and Young Children

Riebenbauer, Katharina; Weber, Philipp; Haitel, Andrea; Walochnik, Julia; Valencak, Julia; Meyersburg, Damian; Kinaciyan, Tamar; Handisurya, Alessandra

doi:10.1016/j.jpeds.2022.02.016

Cited by 9 publications

(7 citation statements)

References 36 publications

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“…Medical management of crusted scabies is challenging for a variety of reasons, including immunocompromised status [ 20 ], polymorphous skin lesions [ 55 ], an abundance of mites [ 4 ], hyperkeratotic lesions [ 24 ], and ineffective penetration of topical agents due to thick crusts [ 56 ]. Therapy failure is a common [ 57 ]. The fundamentals of crusted scabies management include isolation of patients until complete regression [ 58 ]; determining an accurate and adequate therapy that includes topical scabicidal, antiectoparasit, and keratolytic agents [ 14 , 59 ]; symptomatic therapy such as antihistamines and antibiotics for secondary infection [ 14 , 60 ]; comprehensive education and accurate information to the patient and the family members [ 14 , 60 ]; and appropriate skin scraping in the first and fourth week after treatment [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Crusted Scabies, a Neglected Tropical Disease: Case Series and Literature Review

Niode

Adji

Gazpers

et al. 2022

Infectious Disease Reports

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Crusted scabies is a rare form of scabies that presents with more severe symptoms than those of classic scabies. It is characterized by large crusted lesions, extensive scales, thick hyperkeratosis, and contains a large number of highly contagious itch mites. Crusted scabies is more prevalent in immunocompromised, malnourished, and disabled individuals. This disease has been linked to a variety of health problems, including delayed diagnosis, infection risk, and high mortality, mainly from sepsis, and it has the potential to cause an outbreak due to its hyper-infestation, which makes it highly infectious. This article reports three cases of crusted scabies in North Sulawesi, Indonesia. Recent updates and a comprehensive review of the literature on the disease are also included, emphasizing the critical importance of early diagnosis and effective medical management of patients, which are necessary to prevent the complications and spread in communities.

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Section: Discussionmentioning

confidence: 99%

Crusted Scabies, a Neglected Tropical Disease: Case Series and Literature Review

Niode

Adji

Gazpers

et al. 2022

Infectious Disease Reports

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“…Barrutia Etxebarria (2021) (16) encontró una relación marginalmente significativa entre el prurito en convivientes al diagnóstico y el fallo al primer tratamiento (un 90,4 % de los pacientes cuyos convivientes también presentaban prurito fallaron al primer tratamiento, frente a un 79 % de los pacientes cuyos convivientes no presentaban síntomas), pero estas diferencias no fueron significativas al nivel del 5 % (p=0,093). (51,52,53,54,55) En nuestro estudio el antecedente positivo de escabiosis incrementó significativamente superior los días de remisión, así como un riesgo incremental de requerir otro ciclo de tratamiento en comparación con los pacientes sin antecedentes de escabiosis. (56,57,58,59,60,61,62) Los antecedentes de escabiosis incrementan el riesgo de falla del tratamiento porque los ácaros pueden desarrollar resistencia a los medicamentos utilizados para tratar la infestación.…”

Section: Discussionunclassified

Treatment and effectiveness of scabies in first cycle with permethrin 5 % in pediatric population

Ullón,

González-Argote

2023

Salud, Ciencia y Tecnología - Serie de Conferencias

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Introducción: los objetivos del tratamiento son la erradicación de los ácaros del individuo infectado, la prevención de la propagación de la sarna a otros individuos, el alivio del prurito asociado y el reconocimiento y tratamiento de las complicaciones. El tratamiento generalmente incluye a todos en el hogar, incluso si no tienen síntomas: los síntomas pueden tardar de 4 a 6 semanas en desarrollarse después de que una persona está infestada. La sarna se trata más comúnmente con crema dérmica de permetrina al 5 %. Objetivos: describir los factores asociados a la respuesta al tratamiento y efectividad de un primer ciclo con permetrina al 5 % en población pediátrica con escabiosis. Material y métodos: se realizará un estudio observacional, descriptivo, de corte transversal y enfoque retrospectivo, mediante el estudio de historias clínicas de un centro de atención primaria de salud de Avellaneda en la Provincia Buenos Aires, en Argentina. El periodo de estudio comprenderá los registros desde enero 2020 a septiembre 2022. La población del estudio estará constituida por pacientes pediátricos que reciba atención en el centro y sean diagnosticados con escabiosis.

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“…There is variable evidence of the effectiveness as well as safety of topical permethrin and oral ivermectin for treating patients who have scabies. 11,12 The evidence is limited for suggesting that the combination of topical permethrin and oral ivermectin has higher efficacy compared to either treatment given alone. 13,14 In a systematic review, it was revealed that the combination therapy i.e.…”

Section: Table-iv Comparison Of Side Effects Between Three Groupsmentioning

confidence: 99%

Efficacy and safety of oral ivermectin combined with topical permethrin in treatment of scabies.

Saman Iqbal Goraya,

Safoora Aamir,

Beenish Jabeen Bajwa

et al. 2023

TPMJ

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Objective: To determine the efficacy and safety of oral ivermectin and topical permethrin when given either alone or in combination in patients with scabies. Study Design: Randomized Controlled Trial. Setting: Department of Dermatology, Sheikh Zayed Hospital, Lahore. Period: April, 2022 to September, 2022. Material & Methods: A total of 369 patients with scabies, age 18-60 years and both genders were enrolled after taking written informed consent and were randomly and equally divided into three groups. Group A received 5% topical permethrin, Group B received oral Ivermectin and Group C received a combination of topical permethrin and oral ivermectin. Efficacy and safety was assessed over 3 weeks. Results: The mean age of the patients was 4110.9. There were 164 (44.4%) males and 205 (55.6%) females. The treatment in Group A, B and C was efficacious in 70.7%, 67.5% and 84.6% patients respectively and there was a significant difference between Group A versus C (p=0.009) and Group B versus C (p=0.002). In terms of side effects, 11.4% patients in Group A, 13% in Group B and 17% in Group C experienced side effects. Conclusion: The combination therapy was more efficacious than either treatment alone in patients with scabies, however, the side effects were more compared to single agent.

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Comparison of Permethrin-Based Treatment Strategies against Scabies in Infants and Young Children

Cited by 9 publications

References 36 publications

Crusted Scabies, a Neglected Tropical Disease: Case Series and Literature Review

Crusted Scabies, a Neglected Tropical Disease: Case Series and Literature Review

Treatment and effectiveness of scabies in first cycle with permethrin 5 % in pediatric population

Efficacy and safety of oral ivermectin combined with topical permethrin in treatment of scabies.

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