Comparison of pethidine, buprenorphine and ketoprofen for postoperative analgesia after ovariohysterectomy in the cat

Abstract

Sixty cats which underwent an ovariohysterectomy were randomly allocated into four treatment groups. One group (controls) received no analgesics postoperatively, and the others received either a single dose of buprenorphine (0.006 mg/kg) intramuscularly, or pethidine (5 mg/kg) intramuscularly, or ketoprofen (2 mg/kg) subcutaneously. The analgesia obtained after each treatment was assessed by three measures. There were significant differences between the groups both for the requirement for intervention analgesia (P = 0.0008) and for the overall clinical assessment (P = 0.0003) with ketoprofen requiring least intervention analgesia and having the best overall clinical assessment, followed by buprenorphine then pethidine. The control group required the most intervention analgesia and had the worst overall clinical assessment. Visual analogue scale scoring for pain produced significant differences between the groups from one hour after the operation, with the cats which were given ketoprofen tending to have lower pain scores than the other groups.

Comparative analysis of preemptive analgesic effect of tramadol chlorhydrate and nimesulide following third molar surgery

“…Failing to treat pain can lead to postoperative complications, such as a delay in the return to normal activities as well as the possibility of the development of physical alterations in the central nervous system, which can evolve into a clinical condition of chronic pain (Slingsby and Waterman-Pearson, 1998;Dionne et al, 2001).…”

Effect of the ketoprofen on the preemptive analgesia in female cats undergoing to ovariohysterectomy

“…Ketoprofen is more effective than single doses of buprenorphine and pethidine in cats submitted to ovariohysterectomies (Slingsby & Waterman-Pearson, 1998) and has efficacy equivalent to that of three other NSAIDs, carprofen, meloxicam and tolfenamic acid in the same species (Slingsby & Waterman-Pearson, 2000).…”

The influence of demeanor on scores from two validated feline pain assessment scales during the perioperative period

“…The methodology of carrying forward the score an animal receives when it meets criteria for rescue analgesia is commonly employed in clinical pain assessment studies (Slingsby & Waterman-Pearson 1998). The rationale for this approach is: 1) underestimating pain if animals were excluded after administration of rescue analgesia; 2) underestimating pain if post-rescue scores were included instead, and 3) protecting against loss of data if animals are excluded after administration of rescue analgesia.…”