Comparison of Pharmaceutical Properties of Topical Non-steroidal Anti-inflammatory Drug Preparations on Quality of Life

Abstract

To compare the eŠects of diŠerent pharmaceutical properties of commercially available topical nonsteroidal antiin‰ammatory drugs (NSAIDs) on the quality of life, we administered a questionnaire to 65 healthy volunteers. We investigatedˆve creams,ˆve gels, and four solutions of topical NSAID preparations in this study. The survey was conducted to clarify the relationship of their answers and pharmaceutical properties of the topical NSAID preparations. Questions addressed spreadability, smell, viscosity, and comfort level of the topical NSAID preparations. Among theˆve creams, Napageln had lower spreadability, less smell, and greater viscosity than the other preparations. Because of its easy spreadability, weak smell, and low viscosity, the volunteers favored Sector cream among the cream preparations. Among theˆve gel preparations, Inteban had less spreadability, stronger smell, and higher viscosity than the other preparations. The volunteers favored Epatec over the other gel preparations. All four solutions had the odor of menthol and other artiˆcial ingredients, except for Napageln. Theseˆndings indicate that information on the pharmaceutical properties of commercially available topical NSAID preparations will be helpful to physicians and pharmacists in conducting medical treatment and prescribing.

Instrumental and sensory methodologies to characterize the residual film of topical products applied to skin

“…High differences of Stickiness and Amount of Residue were also perceived among the products. And a different feel is presumed to be a factor that directly affects compliance …”

“…And a different feel is presumed to be a factor that directly affects compliance. 23 Hence, this work proposes a sensory methodology particularly well adapted to the evaluation of the texture of topical products.…”

Generic selection criteria for safety and patient benefit [VII]: Comparing the physicochemical and pharmaceutical properties of brand-name and generic terbinafine hydrochloride cream

“…External preparations need to have adequate physiological/sensory properties, such as the sense of touch, ductility, color, and smell, in addition to pharmaceutical or pharmacological properties (14). As patients apply ointment or cream preparations to an affected site with their hands, low-ductility viscous preparations may be difficult to apply.…”

Quality by Design: Development of the Quality Target Product Profile (QTPP) for Semisolid Topical Products

“…Differences in viscoelastic properties may lead to differences in spreadability of the topical formulation leading to dissimilarity in skin feel. Patients apply topical formulations on their skin directly, and so sensorial attributes are assumed to be significant factors that can directly influence patient compliance [29,30]. Rheological properties of the formulation are a combination of CMSs and CPPs as well as the shear history of the manufactured product.…”