Comparison of pharmacokinetic profiles of single and multiple doses of a slow release Oros oxprenolol delivery system in young normotensive and elderly hypertensive subjects.

Abstract

Oxprenolol in an Oros 8/130 sustained release osmotic pump system (equivalent to 120 mg oxprenolol hydrochloride in a conventional formulation and releasing 8 mg h‐1) was given to eight normal young subjects (mean age 23 years) and eight elderly hypertensive patients (mean age 77 years). The plasma concentration‐time profiles of oxprenolol were determined over 32 h using gas liquid chromatography after the initial dose and following seven doses. The elderly patients had a significantly higher AUC and maximum plasma oxprenolol concentration following both the first and final doses studied. It is unlikely that this difference is due to a prolonged absorption phase in the elderly patients. Reduced drug clearance seems the most probable explanation.

Sequential Injection Method for the Determination of Oxprenolol in Pharmaceutical Products Using Chemometric Methods of Optimization

“…The computer was also used to collect the data; alternatively, the data were recorded with a Model 0555 single-channel strip-chart recorder (Cole Parmer Instrument Co., Chicago, IL). 6. A Perkin-Elmer Lambda 5 UV/visible spectrophotometer equipped with 10.00mm cells was used for preliminary investigations.…”

“…Most assay methods for oxprenolol available in the literature are suitable for its determination in biological fluids such as serum and urine (4)(5)(6)(7)(8)(9). A kinetic method has also been described using the fixed time method (10).…”