2012
DOI: 10.1016/j.jns.2011.12.012
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Comparison of phosphorylated TDP-43-positive inclusions in oculomotor neurons in patients with non-ALS and ALS disorders

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Cited by 12 publications
(10 citation statements)
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“…Involvement of the oculomotor nucleus (N. III) has been reported before in ALS [39], including cases with long-term survival on a respirator [24, 32, 33]. Moreover, our proposed stage 5 cases displayed massive and widespread neuronal loss that resulted in a marked bilateral atrophy of spinal cord anterior horns (Fig.…”
Section: Discussionsupporting
confidence: 58%
“…Involvement of the oculomotor nucleus (N. III) has been reported before in ALS [39], including cases with long-term survival on a respirator [24, 32, 33]. Moreover, our proposed stage 5 cases displayed massive and widespread neuronal loss that resulted in a marked bilateral atrophy of spinal cord anterior horns (Fig.…”
Section: Discussionsupporting
confidence: 58%
“…In patients with intraneuronal pTDP-43 inclusions in the spinal cord the OMNs rarely contain similar inclusions. In the few cases where such inclusions were found patients had been maintained on respiratory support or had very extensive pTDP-43 inclusion pathology that did not confine to predefined pathology staging [17, 129]. Analysis in end-stage SOD1 G93A mice demonstrated that OMNs appeared largely devoid of SOD1 and p62-positive inclusions, indicating that autophagy was unaffected here.…”
Section: The Oculomotor Systemmentioning
confidence: 99%
“…In addition to the characteristic round neuronal cytoplasmic inclusions, TDP-43 inclusions can be observed as dash- or dot-like inclusions, skein-like filamentous inclusions, nuclear cat-eye inclusions, neuritic tangles, and cytoplasmic and nuclear glial inclusions [23,37,40,41]. A number of initial reports examining TDP-43 pathology noted variation in the types of TDP-43 positive inclusions between patients [23,38,40,41,51].…”
Section: Introductionmentioning
confidence: 99%