Comparison of photoreactions of flutamide in acetonitrile and 2-propanol solvents in the absence of cage-forming compounds

Investigation of photoreaction for 2-nitrobenzofuran and its 3-methyl derivative

“…For example, the photoreactions of flutamide, which is used as an anticancer drug used for prostate cancer treatment [25], have been investigated from different perspectives in pharmacology, photochemistry, and photophysics. [26][27][28]. When this medication was prescribed, patients often experienced photodermatosis as a rare, adverse side effect [29][30].…”

“…This photoinduced skin disorder was believed to be due to the irradiation of sunlight, which prompted further investigation on the photoreactivity of flutamide. Through in vitro experiments, it was determined that certain photoreactions of flutamide that included nitro-nitrite rearrangements and photoreductions were caused by UV irradiation [26][27][28]. The causal relationship between the photoreactivity of flutamide and photodermatosis are still being investigated.…”

“…The photoreactions of nitro-substituted aromatic hydrocarbons have also been thoroughly examined [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][26][27][28]. In the photoreactions of nitro-substituted aromatic heterocycles, R. Hunt and S. T. Reid specifically investigated the photorearrangements of fivemembered nitroheteroaromatic systems such as 2-nitrofuran and 2-nitropyrrole.…”