Aim: To explore the nutrients, minerals, beta-carotene and total carotenoid contents of five sweet potato varieties viz., Agric orange flesh, Agric white, Red skin, Orange flesh and T.U. purple. Study Design: The sweet potato vines at six week stage were cut into 1.2m each and transplanted in parallel lines on the same 1.2m x 2.6m bed, spaced about 0.52m from each other in Dukumah Garden. There were five such beds and vine cuttings transplanted in the same order on each bed. Study Site: The study, which took four months, was conducted in the Dukumah Garden in Bolgatanga Municipality (10.7875° N, 0.8580° W) of the Upper East Region of Ghana. Methodology: The sweet potatoes were harvested four months after transplanting on the same day. Samples of the various varieties were collected, parcelled, appropriately labelled and handdelivered to the Food Chemistry Laboratory of Kwame Nkrumah University of Science and Technology for the analysis of proximate analysis (%), total carotenoids and beta-carotene concentrations in mg/g and concentrations of the minerals, namely magnesium (Mg), sodium (Na), potassium (K), calcium (Ca), iron (Fe) and zinc (Zn) in mg/kg. Results: All the five varieties of sweet potato were found to be nutritious. Protein content ranged from 3.82% in Agric white variety to 0.11% in Agric orange flesh. Fat content ranged from 4.84% in orange flesh variety to 1.74% in red skin. Crude fibre content was between 1.77% in Agric orange flesh and 0.10% in T.U. purple. Total carbohydrate varied from 23.2% in Agric orange flesh variety to 15.8% in Agric white one. Moisture was high in all the varieties, ranging from 75.78% in Agric white variety to 71.04% in Orange flesh one. The Orange flesh variety had the highest ash content of 1.56%. All the varieties contained high concentrations of Mg but low concentrations of Na and K. The highest concentration of Ca (8250.70±0.06 mg/kg) was recorded in T.U. purple. The concentrations of Fe in the sweet potato varieties decreased in the following order: T.U. purple>Red skin>Orange flesh>Agric orange flesh>Agric white. The highest (123.12±0.00 mg/kg) and the lowest (33.10±0.00 mg/kg) Zn concentration were recorded in the orange flesh Agric white varieties, respectively. The concentration of beta-carotene (mg/kg) in five sweet potato varieties was in the following order: Agric orange flesh<