Comparison of Pituitary-Adrenal Function in Rats Lesioned in Different Areas of the Limbic System and Hypothalamus

Usher, David R.; Kasper, Phyllis; Birmingham, Marion K.

doi:10.1159/000121544

Cited by 45 publications

(14 citation statements)

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“…Septally-lesioned animals characteristically are behaviorally over-reactive to stimulation [Seggie, 1968] and show diurnal variation in this reactivity [Seggie, 1970]. Data [Endroczi and Nyakas, 1971;Seggie and Brown, 1973;M urgas and Kvetnansky, in press; Brown et al, 1974] also indicate that the plasma corticosterone response to stress in septallylesioned animals is increased although Usher et al [1967] indicate that septal damage prevents the stress-evoked elevation of plasma corticosterone.…”

Section: Discussionmentioning

confidence: 99%

Baseline 24-Hour Plasma Corticosterone Rhythm in Normal, Sham-Operated and Septally-Lesioned Rats

Seggie¹,

Shaw²,

Uhlir³

et al. 1974

Neuroendocrinology

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In order to test whether septal ablation alters the resting 24-hour plasma corticosterone rhythm or increases sensitivity to stimulation, baseline 24-hour plasma corticosterone values were measured in normal, sham-operated and septally-lesioned rats under ‘standard’ and ‘rigorous’ environmental conditions. Mapping the rhythm at 4-hour intervals in 24 h confirmed that there is an elevation in the rhythm around trough time following septal damage under the standard environmental condition, as previously reported. In contrast, an 8-point map of the rhythm, determined under rigorously controlled environmental conditions, demonstrated that following septal ablation in rats, the 24-h baseline rhythm in plasma corticosterone is identical to that seen in normal and sham-operated animals. Thus, the hypothesis is borne out that although the baseline adrenal function is normal in septally-lesioned rats, adrenal responses to stimulation are enhanced.

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Section: Discussionmentioning

confidence: 99%

Baseline 24-Hour Plasma Corticosterone Rhythm in Normal, Sham-Operated and Septally-Lesioned Rats

Seggie¹,

Shaw²,

Uhlir³

et al. 1974

Neuroendocrinology

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“…However, recent findings [Lengvari and H alAsz, 1973;W ilson and C ritchlow, 1973] suggest that this system is not essential for this function. Because the septum is another forebrain structure with appropriate connections to MBH [Raisman, 1966;M illhouse, 1969] and because it is capable of influencing the pituitary-adrenal axis [Usher et al, 1967;Seggif., 1968;Endroczi and N yakas, 1970; Seggie and Brown, 1971], the present experiments were designed to determine whether it is essen tial for rhythmic pituitary-adrenal function.…”

mentioning

confidence: 99%

Effect of Septal Ablation on Rhythmic Pituitary-Adrenal Function in the Rat

Wilson¹,

Critchlow²

1974

Neuroendocrinology

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To test the possibility that the septum is essential forrhythmic pituitary-adrenal function, septal nuclei and fibers were re-moved by suction from adult female rats. Rhythmic pituitary-adrenal function was assessed by fluorometric measurement of non-stress plasma corticosterone in blood samples obtained at different times during the 24 h light-dark cycle. At 3 and 5 weeks after surgery, a.m. and p.m. non-stress plasma corticosterone levels were comparable in all groups, and all groups showed significant diurnal variations in steroid levels. Diurnal steroid patterns were studied in individual rats at 9 weeks after surgery by collecting 3 blood samples (0.5 ml) at 10 h intervals (07.00, 17.00, 03.00). Septal ablation, with concomitant interruption of fornix, was compatible with normal diurnal variations in plasma corticosterone concentrations. Lesioned rats demonstrated vaginal cycles and normal numbers of tubal ova at estrus. The data indicate that the diurnal pituitary-adrenal rhythm persists in the absence of septum and fornix and suggest that these structures are not essential for this rhythm.

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“…Although it is not clear why p-CPA affects the reactivity of septal lesioned rats, it is apparent that the mechanism of action does not involve the depletion of brain serotonin. Although adrenal hypertrophy has been found in rats with septal lesions when placed in stressful situations (Montgomery & Berkut, 1969;Usher et al, 1967), it does not appear that septal hyper-reactivity is dependent upon adrenal hyperfunction, as adrenalectomy does not alter the effects of subsequent septal injury (Seggie, 1971).…”

mentioning

confidence: 99%

The Septum and Hyper‐reactivity: A Review

Fried

1973

British J of Psychology

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The literature related to one form of septal dysfunction ‐ hyper‐reactivity ‐ is reviewed. The increase in reactivity following septal damage is considered in terms of its reliability and the many factors which influence its attenuation and release. Research discussed includes the topics of anatomical locus of septal damage, species and strain investigated, pre‐ and post‐operative handling, neurochemical factors, and the relationship of hyper‐reactivity to other septal dysfunctions and other anatomical structures.

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Comparison of Pituitary-Adrenal Function in Rats Lesioned in Different Areas of the Limbic System and Hypothalamus

Cited by 45 publications

References 0 publications

Baseline 24-Hour Plasma Corticosterone Rhythm in Normal, Sham-Operated and Septally-Lesioned Rats

Baseline 24-Hour Plasma Corticosterone Rhythm in Normal, Sham-Operated and Septally-Lesioned Rats

Effect of Septal Ablation on Rhythmic Pituitary-Adrenal Function in the Rat

The Septum and Hyper‐reactivity: A Review

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