Comparison of pneumonia- and non-pneumonia-related Acinetobacter baumannii bacteremia: Impact on empiric therapy and antibiotic resistance

Teng, Sing On; Yen, Muh Yong; Ou, Tsong Yih; Chen, Fu Lun; Yu, Fenglei; Lee, Wen Sen

doi:10.1016/j.jmii.2014.06.011

Cited by 24 publications

(19 citation statements)

References 22 publications

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“…The outbreak of A. baumannii infection is also associated with multidrug resistance, and carbapenems have been considered to be a major factor in resistance to multidrug-resistant A. baumannii infection [34]. Moreover, the mortality of carbapenem-resistant A. baumannii pneumonia patients is higher than that of carbapenem-sensitive A. baumannii pneumonia patients [35,36].…”

Section: Discussionmentioning

confidence: 99%

Etiology and characteristics of community-acquired pneumonia in an influenza epidemic period

Lin

Chen

et al. 2019

Comparative Immunology, Microbiology and Infectious Diseases

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A B S T R A C TPurpose: The etiology of community-acquired pneumonia (CAP) in hospital patients is often ambiguous due to the limited pathogen detection. Lack of a microbiological diagnosis impairs precision treatment in CAP. Methods: Specimens collected from the lower respiratory tract of 195 CAP patients, viruses were measured by the Single-plex real-time PCR assay and the conventional culture method was exploited for bacteria. Results: Among the 195 patients, there were 46 (23.59%) pure bacterial infections, 20 (10.26%) yeast infections, 32 (16.41%) pure viral infections, 8 (4.10%) viral-yeast co-infections, and 17 (8.72%) viral-bacterial co-infections. The two most abundant bacteria were Acinetobacter baumannii and klebsiella pneumoniae, whereas the most common virus was influenza A. Conclusions: Non-influenza respiratory microorganisms frequently co-circulated during the epidemic peaks of influenza, which easily being ignored in CAP therapy. In patients with bacterial and viral co-infections, identifying the etiologic agent is crucial for patient's therapy. infection enhanced susceptibility to pneumococcal pneumonia by about

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Section: Discussionmentioning

confidence: 99%

Etiology and characteristics of community-acquired pneumonia in an influenza epidemic period

Lin

Chen

et al. 2019

Comparative Immunology, Microbiology and Infectious Diseases

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“…Acinetobacter baumannii is an important nosocomial pathogen that causes pneumonia, bacteremia, meningitis, urinary tract infections, and other inflammation-related diseases [ 1 – 5 ]. It is difficult to treat A. baumannii infections owing to the occurrence of drug resistance and the ability of the pathogen to propagate worldwide.…”

Section: Introductionmentioning

confidence: 99%

Biofilm-Related Genes: Analyses in Multi-Antibiotic Resistant Acinetobacter Baumannii Isolates From Mainland China

Liu

Chen

et al. 2016

Med Sci Monit

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BackgroundAcinetobacter baumannii is an important nosocomial pathogen which shows a high level of mortality risk. Several papers have reported biofilm formation as a well-known pathogenic mechanism in A. baumannii infections and exceptional antibiotic resistance. The study aims to explore the potential relationships between biofilm-related genes and antimicrobial resistance.Material/MethodsSamples from 122 patients with lower respiratory tract infections of A. baumannii were collected at Fujian Longyan First Hospital from January 2013 to September 2014. A. baumannii was isolated from sputum specimens. Biofilm-related genes including abaI, csuE, ompA, and bla-PER1 were analyzed by PCR. The minimum inhibitory concentration method was used to determine the sensitivity of each strain to antibiotics.ResultsThe clinical manifestations of A. baumannii-induced lower respiratory tract infections lacked specificity. Infected patients were most commonly admitted to intensive care units (54.9%) and frequently had chronic obstructive pulmonary disease (27.0%). The detection rates of abaI and csuE were both 59.8%, and those of ompA and bla-PER1 were 100% and 0%, respectively. After genetic testing, antimicrobial resistance to amikacin, ampicillin/sulbactam, and 14 other types of antimicrobials was higher in abaI- and csuE-positive strains than in abaI- and csuE-negative strains (P<0.05).ConclusionsThe findings of our study suggest that abaI- and csuE-positive Acinetobacter baumannii strains are associated with a higher incidence of antibiotic resistance in 14 types of antimicrobials.

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“…baumannii bacteremic pneumonia (BP) was defined as isolation of A . baumannii from at least one blood culture and one LRT sample culture in the same HAP/VAP patient within 48 hours 6 . Furthermore, the positive blood culture of A .…”

Section: Methodsmentioning

confidence: 99%

“…aeruginosa and A . baumannii , which have high incidence of colonization in LRT, some authors suggest defining pneumonia caused by a “definite pathogen” as bacteremic pneumonia (BP), and the one caused by a “probable pathogen” or a “possible pathogen” as non-bacteremic pneumonia (NBP) 6 , 7 .…”

Section: Introductionmentioning

confidence: 99%

“…Numerous studies have investigated the risk factors and mortality of A. baumannii bacteremia, with findings consistently suggesting that A. baumannii bacteremia has a higher mortality rate than other organisms, ranging from 30% to 60%, especially for imipenem-resistant A. baumannii 6 , 8 . However, it remains unclear what the attributed mortality of A. baumannii bloodstream infections is by different sites of infection.…”

Section: Introductionmentioning

confidence: 99%

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Bacteremic and non-bacteremic pneumonia caused by Acinetobacter baumannii in ICUs of South China: A Clinical and Microbiological Study

Tan

Zhou

Tang

et al. 2017

Sci Rep

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Acinetobacter baumannii has been a dreadful problem for ICU physicians for a long time. Bacteremic pneumonia (BP) caused by this organism has a higher mortality compared to other organisms. Between 2012 and 2015, 86 BP and 89 non-bacteremic pneumonia (NBP) patients from five ICUs were enrolled into the study. The 7-day and 14-day mortality rates were higher in BP patients than in NBP patients (P < 0.001). Procalcitonin elevation, high APACHEII score and recent surgery, were independently associated with BP episodes. Acute respiratory distress syndrome, coma, high APACHEII score and procalcitonin elevation, were independently associated with mortality in the BP group. Extensively drug-resistant isolates were detected in 34.9% of BP and 25.8% of NBP isolates. PFGE identified 12 and 9 genotypes in the BP and NBP isolates, respectively, with 6 genotypes shared by both groups. ST195 was the most prevalent type (40%), followed by ST457 (18.9%). The pandemic clonal complex 92 was predominant, accounting for 94.3% of the strains. For all studied periods, mortality remained higher in the BP than the NBP group. Disease severity was the main risk factor for high mortality in the BP group, and other factors related to mortality were infection, and not treatment or microbiology-related.

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Comparison of pneumonia- and non-pneumonia-related Acinetobacter baumannii bacteremia: Impact on empiric therapy and antibiotic resistance

Abstract: Pneumonia-related AB bacteremia has a worse outcome, more antibiotic resistance, and more comorbidity than the nonpneumonia group.

Cited by 24 publications

References 22 publications

Etiology and characteristics of community-acquired pneumonia in an influenza epidemic period

Etiology and characteristics of community-acquired pneumonia in an influenza epidemic period

Biofilm-Related Genes: Analyses in Multi-Antibiotic Resistant Acinetobacter Baumannii Isolates From Mainland China

Bacteremic and non-bacteremic pneumonia caused by Acinetobacter baumannii in ICUs of South China: A Clinical and Microbiological Study

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