Comparison of posttransfusion recoveries achieved with either fresh or stored platelet concentrates

Abstract

The effectiveness of platelet concentrate transfusion depends on such variables as blood bag material, donor--recipient compatibility, and time elapsed between donation and transfusion. To study the latter a corrected thrombocyte increment for recovery in the recipients was evaluated with 108 platelet transfusions in 31 patients. In 83 treatment programs, the mean recovery at the one-hour post-transfusion time point was 8.6 X 10(9) platelets/l with fresh platelets and 5.9 X 10(9) platelets/l with stored platelets. Significantly better recovery was achieved with freshly prepared platelet over the total of platelet concentrates stored for up to 96 hours; however, if the recoveries in different patient groups given stored platelets were considered separately in terms of storage times of up to 48 h or 48-96 h, the good recovery with fresh platelets was significantly better only when compared to the older (p = 0.034) but not to the younger group of stored platelets. In patients with signs indicating enhanced platelet destruction (fever, splenomegaly, disseminated intravascular coagulation) the transfusion with fresh platelet concentrates gave a significantly better recovery compared to stored platelet concentrates (p = 0.028), whereas in the absence of such signs the recovery produced by fresh concentrates was not significantly higher than with stored concentrates. These findings may be relevant for the logistics in blood banking.

Clinical consequences of alterations in platelet transfusion dose: a prospective, randomized, double‐blind trial

“…The age of the platelet component is often regarded as affecting clinical efficacy 29,30 . However, the studies that support this concept 29,30 report that only those platelets transfused less than 24 to 48 hours after collection appear to be more efficacious than older platelets, and usually only in certain situations, such as refractoriness due to infection. However, in most United States centers, it is not possible to transfuse platelets less than 48 hours after collection, because of testing, labeling, and distribution constraints.…”

Intravascular and total body platelet equilibrium in healthy volunteers and in thrombocytopenic patients transfused with single donor platelets

“…O'Connell et al [9] infused their platelet dose within 30 min, but practically, most intravenous therapists infuse platelets for an hour or more, though it has been advised to transfuse platelets within 10-20 min [28]. Most studies give no indication as to the length of time for their platelet infusions, nor to the length of platelet storage, which also impacts platelet counting methods [29].…”

Factors affecting posttransfusion platelet increments, platelet refractoriness, and platelet transfusion intervals in thrombocytopenic patients

“…Longer platelet storage times have been reported to decrease posttransfusion platelet viability. [20][21][22][23] However, some investigators have suggested that storage adversely affects only platelet concentrates rather than apheresis platelets. 24 In our study, an equal benefit of platelets stored for 48 hours or less was seen for all the types of platelets transfused.…”