Comparison of Posttraumatic Stress Disorder Checklist Instruments From <i>Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition </i>vs <i>Fifth Edition</i> in a Large Cohort of US Military Service Members and Veterans

LeardMann, Cynthia A.; McMaster, Hope Seib; Warner, Steven; Esquivel, Alejandro P.; Porter, Ben; Powell, Teresa M.; Tu, Xin; Lee, William W.; Rull, Rudolph P.; Hoge, Charles W.

doi:10.1001/jamanetworkopen.2021.8072

Cited by 44 publications

(30 citation statements)

References 24 publications

(64 reference statements)

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“…The IES-R cut-off scores for a preliminary PTSD diagnosis are supported in the literature [ 38 , 39 ]. More than 50% of the subjects in this study had scores ≥33 reflecting a probable diagnosis of PTSD, however, there is a need to confirm the PTSD diagnosis using a diagnostic interview for PTSD—the DSM-5 PCL (PTSD Checklist; PCL)—and to address the overlap and boundaries between ICD-11 definitions of complex post-traumatic stress disorder (C-PTSD) and personality disorder [ 64 , 65 , 66 , 67 ].…”

Section: Discussionmentioning

confidence: 99%

Brainstem Quadruple Aberrant Hyperphosphorylated Tau, Beta-Amyloid, Alpha-Synuclein and TDP-43 Pathology, Stress and Sleep Behavior Disorders

Calderón‐Garcidueñas

Rajkumar

Stommel

et al. 2021

IJERPH

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Quadruple aberrant hyperphosphorylated tau (p-τ), amyloid-β peptide, alpha-synuclein and TDP-43 brainstem and supratentorial pathology are documented in forensic ≤40y autopsies in Metropolitan Mexico City (MMC), and p-τ is the major aberrant protein. Post-traumatic stress disorder (PTSD) is associated with an elevated risk of subsequent dementia, and rapid eye movement sleep behavior disorder (RBD) is documented in PD, AD, Lewy body dementia and ALS. This study aimed to identify an association between PTSD and potential pRBD in Mexico. An anonymous online survey of 4502 urban college-educated adults, 29.3 ± 10.3 years; MMC, n = 1865; non-MMC, n = 2637, measured PTSD symptoms using the Impact of Event Scale–Revised (IES-R) and pRBD symptoms using the RBD Single-Question. Over 50% of the participants had IES-R scores ≥33 indicating probable PTSD. pRBD was identified in 22.6% of the participants across Mexico and 32.7% in MMC residents with PTSD. MMC subjects with PTSD had an OR 2.6218 [2.5348, 2.7117] of answering yes to the pRBD. PTSD and pRBD were more common in women. This study showed an association between PTSD and pRBD, strengthening the possibility of a connection with misfolded proteinopathies in young urbanites. We need to confirm the RBD diagnosis using an overnight polysomnogram. Mexican women are at high risk for stress and sleep disorders.

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Section: Discussionmentioning

confidence: 99%

Brainstem Quadruple Aberrant Hyperphosphorylated Tau, Beta-Amyloid, Alpha-Synuclein and TDP-43 Pathology, Stress and Sleep Behavior Disorders

Calderón‐Garcidueñas

Rajkumar

Stommel

et al. 2021

IJERPH

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“…We are also limited by the reliance on a self-report measure based on prior diagnostic criteria for PTSD ( 91 ). However, a recent study ( 92 ) suggests substantial agreement between the PCL-C used in this study and newer version of the PCL developed for use with DSM-5 ( 93 ). With pilot data that supports our hypotheses that our treatment can improve symptoms in a lasting way, future studies should aim to offer these clinical services to more women to reach stronger conclusions about effects of mental health services offered during pregnancy to positively impact pregnancy and birth outcomes.…”

Section: Discussionmentioning

confidence: 58%

Engagement in and Benefits of a Short-Term, Brief Psychotherapy Intervention for PTSD During Pregnancy

et al. 2022

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Trauma-related symptoms and post-traumatic stress disorder (PTSD) are common during pregnancy and have adverse effects on pregnancy and birth outcomes, post-partum maternal mental health, and child development. The arousal symptoms associated with PTSD, including heightened or dysregulated physiology, may contribute to these adverse outcomes. Low-income minoritized women may be at highest risk given more lifetime exposure to trauma and limited access to mental health care. While evidence-based psychotherapies for PTSD exist, none are targeted to non-treatment seeking individuals nor specifically integrated with prenatal care. Thus, we developed and tested the efficacy of a short-term (four sessions) brief (30–45 min) psychotherapeutic intervention designed to address PTSD symptoms in pregnant women receiving prenatal care at two urban medical centers. Participants were 32 pregnant women with an average gestational age of 18.5 weeks at the time of enrollment. The sample was overwhelmingly non-Caucasian, single, and reported very low income. Participants completed measures of trauma-related symptoms (Post-traumatic Stress Disorder Checklist, PCL), and depression (Edinburgh post-natal Depression Scale, EPDS) at baseline, twice during treatment, post-treatment, and at 10–14 weeks post-partum. The intervention was successful at significantly decreasing symptoms of PTSD (PCL score = −20.27, 95% CI: −25.62, −14.92, P < 0.001, W = −7.43) and depression (EPDS score = −4.81, 95% CI: −7.55, −2.06, P = 0.001, W = −3.23) by the final session. These benefits were sustained at post-treatment and post-partum follow ups. Future research should further explore the effectiveness of this treatment in a randomized controlled trial.

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“…PCL-C-5 consists of 17 items, which comprise three domains: reexperiencing, avoidance, and hyperarousal. 27 The three domains correspond to the DSM-IV symptoms for PTSD 27 on a 5 Likert scale based on the extent to which the respondent has been troubled by specific symptoms in the past month. The total possible score is calculated by summing up the scores for all the items, and it ranges from 17 to 85 points.…”

Section: Methodsmentioning

confidence: 99%

Post-Traumatic Stress Disorder and Coping Strategies Among People with HIV in Lira District, Uganda: A Cross-Sectional Study

Arebo¹,

Ewach²,

Omara³

et al. 2022

HIV

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Background Post-traumatic stress disorder (PTSD) is the most commonly reported mental health consequence following traumatic events. However, little is known about how people with HIV cope with the PTSD burden in Lira city, northern Uganda. Materials and Methods This study was carried out in Lira District Health Centre IVs from February 10, 2022, to March 10, 2022. A facility-based cross-sectional study was employed among 390 people with HIV attending Lira Health Centre IVs. A consecutive sampling technique was used to select the sample size. Questionnaires were used to collect data. A binary logistic regression model was fitted to identify factors associated with independent variables, and AOR was employed to estimate the strength of association between independent and dependent variables. Results Results show that the estimated prevalence of PTSD was 254 (65.1%) and was higher among the females 191 (75.2%), those with no formal education 143 (56.3%), aged 40 years and above 121 (47.6%), and married 127 (50.0%). Results indicate that male respondents had a 51% reduced odds of developing PTSD burden compared to female respondents (AOR: 0.49; 95% CI: 0.30–0.81; P = 0.005). Individuals who did not use planning activities as a coping strategy had more than 2-fold increased odds of experiencing PTSD compared to those who planned activities (AOR: 2.43; 1.26–4.70; P = 0.008). Participants who did not have emotional support had close to 3-fold increased chances of developing PTSD compared to those who had emotional support (AOR: 2.94; 1.74–4.98; P ≤ 0.001). Participants who indicated they were not taking recourse to spirituality had more than 4-fold increased odds of experiencing PTSD compared to those who had spirituality (AOR: 4.40; 1.83–10.46; P = 0.001). Conclusion A considerable burden of PTSD among HIV clients attending health centre IVs in Lira District was notably higher and was associated with gender, planning activities, emotional support and spirituality. Early screening of PTSD among HIV clients is needed to alleviate the burden. There is also a need to include PTSD treatment services in the treatment programme of HIV care services in health centre IVs in Lira District.

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Comparison of Posttraumatic Stress Disorder Checklist Instruments From Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition vs Fifth Edition in a Large Cohort of US Military Service Members and Veterans

Cited by 44 publications

References 24 publications

Brainstem Quadruple Aberrant Hyperphosphorylated Tau, Beta-Amyloid, Alpha-Synuclein and TDP-43 Pathology, Stress and Sleep Behavior Disorders

Brainstem Quadruple Aberrant Hyperphosphorylated Tau, Beta-Amyloid, Alpha-Synuclein and TDP-43 Pathology, Stress and Sleep Behavior Disorders

Engagement in and Benefits of a Short-Term, Brief Psychotherapy Intervention for PTSD During Pregnancy

Post-Traumatic Stress Disorder and Coping Strategies Among People with HIV in Lira District, Uganda: A Cross-Sectional Study

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