Comparison of potential protective effects of melatonin and propylthiouracil against lipid peroxidation caused by nitrobenzene in the thyroid gland

Zasada, Krzysztof; Karbownik-Lewińska, Małgorzata

doi:10.1177/0748233713491799

Cited by 10 publications

(6 citation statements)

References 30 publications

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“…[23] The reduced thyroid parameters in ketoconazoleadministered rats pretreated or post-treated with melatonin might result from both drug interaction, as ketoconazole has been shown to increase tasimelteon (a novel melatonin receptor agonist) activity because of its ability to inhibit CYP3A4/5. [36] It could also result from modulation of iodothyronine deiodinases in the brain, thyroid gland and peripheral tissues by melatonin, [37] and protective activity of melatonin against any oxidative stress [38] that might have been induced by ketoconazole. These then suggest that melatonin can increase or reduce thyroid parameters depending on conditions such as duration and time of administration, [39] concentration and light/dark cycle, [40] type of the animal, [41] and drug-drug interaction.…”

Section: Discussionmentioning

confidence: 99%

Melatonin ameliorates ketoconazole-induced increase in thyroid function

Alagbonsi

Olayaki

Abdulrahim

et al. 2020

RJMHS

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Background The antithyroid effect of ketoconazole has been reported. The secretion and action of melatonin in the thyroid gland are also known. However, the possible effect of melatonin on ketoconazole-induced antithyroid effect is unknown. Objective We sought to investigate the modulatory effect of ketoconazole and/or melatonin on thyroid function in female rats. Methods Groups 1-4 of female rats respectively underwent 14-day treatment with normal saline, 25 mg/kg ketoconazole, 4 mg/kg melatonin and 10 mg/kg melatonin. Groups 5 and 6 both received 14-day treatment with ketoconazole and were respectively treated with 4 mg/kg melatonin and 10 mg/kg melatonin simultaneously. Groups 7 and 8 respectively underwent 14-day pretreatment with 4 mg/kg melatonin and 10 mg/kg melatonin, followed by 14-day administration of ketoconazole to both groups. Groups 9 and 10 were both treated with ketoconazole for 14 days, followed by respective 14-day administration of 4 mg/kg melatonin and 10 mg/kg melatonin. Results TSH, T3, T4, and iodine concentrations were increased by separate administration of ketoconazole and either dose of melatonin when compared to control. However, pre-treatment or post-treatment of ketoconazole-treated rats with melatonin abolished the ketoconazole-induced increase in TSH, T3, T4, and iodine while co-administration of ketoconazole with melatonin caused no improvement in the ketoconazole-induced increase in TSH, T3, and T4 except iodine concentration. Conclusion Ketoconazole increased thyroid function, which was ameliorated by pre- or post-treatment with melatonin, possibly via modulation of the iodination process. Keywords: Iodine; Ketoconazole; Melatonin; Thyroid function; Toxicity

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Section: Discussionmentioning

confidence: 99%

Melatonin ameliorates ketoconazole-induced increase in thyroid function

Alagbonsi

Olayaki

Abdulrahim

et al. 2020

RJMHS

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“…These unique characteristics have made melatonin the subject of investigation into medical conditions in which oxidative stress has been implicated, including diabetes, glaucoma, irritable bowel syndrome and even in curtailing the side effects of chemo-and radiotherapy [48,49]. Melatonin has been shown to suppress tumour growth factors and angiogenesis, suggesting a possible role for melatonin in prevention of cancer growth [9,50,51]. Furthermore, melatonin has been shown to have antiinflammatory and DNA stabilising actions in the lung [6,52], skin and intestine [53][54][55][56] and can help reduce chronic pelvic pain in women with endometriosis [57].…”

Section: Actions As An Oxygen Scavengermentioning

confidence: 99%

Melatonin: shedding light on infertility? - a review of the recent literature

Fernando

Rombauts

2014

Journal of Ovarian Research

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In recent years, the negative impact of oxidative stress on fertility has become widely recognised. Several studies have demonstrated its negative effect on the number and quality of retrieved oocytes and embryos following in-vitro fertilisation (IVF). Melatonin, a pineal hormone that regulates circadian rhythms, has also been shown to exhibit unique oxygen scavenging abilities. Some studies have suggested a role for melatonin in gamete biology. Clinical studies also suggest that melatonin supplementation in IVF may lead to better pregnancy rates. Here we present a critical review and summary of the current literature and provide suggestions for future well designed clinical trials.Electronic supplementary materialThe online version of this article (doi:10.1186/s13048-014-0098-y) contains supplementary material, which is available to authorized users.

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“…Melatonin influenced thyroid hormones levels by controlling iodothyronine-deiodinases. Melatonin has an inhibitory effect on cell proliferation and thyroid hormone synthesis and a protective effect against oxidative damage in the thyroid gland [10–12]. The inhibition of thyroid growth and/or thyroid function by the pineal gland, as well as the stimulation of the pineal gland activity and growth processes by the thyroid hormones, have prompted a hypothesis on the existence of a reciprocal relationship between the thyroid and the pineal [13].…”

Section: Introductionmentioning

confidence: 99%

Changes in thyroid hormones, leptin, ghrelin and, galanin following oral melatonin administration in intact and castrated dogs: a preliminary study

et al. 2019

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Background Melatonin regulates metabolism and metabolism related hormones in mammalians. Castration has some adverse effects on the metabolic hormones of dog. This study was conducted to determine the effects of oral melatonin administration on metabolic hormones, as well as to compare changes of these hormones after administration of melatonin in castrated and intact dogs. Twenty healthy mixed breed mature male dogs were divided randomly into four groups ( n = 5): melatonin (3 mg/10 kg(, castrated, castrated and melatonin treated, and negative control. Blood sample was collected from jugular vein weekly for 1 month. Results T3 and T4 hormones had a significant decrease within 1 month following administration of melatonin. No significant change was observed in concentration of FT3 and FT4 hormones. Leptin and ghrelin hormones also had a significant decrease in this period. Leptin and ghrelin had a more significant decrease in “non-castrated and melatonin treated” group compared to “castrated and melatonin treated” group. Galanin had a significant decrease but this neurotransmitter had no significant change in “non-castrated and melatonin treated” group in comparison to “castrated and melatonin treated” group. Conclusions It seems that daily administration of melatonin capsule in all dogs can probably decrease concentration of T3 and T4 hormones and balance other metabolic hormones following castration. Methods The dogs underwent castration, melatonin treatment and blood sampling.

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Comparison of potential protective effects of melatonin and propylthiouracil against lipid peroxidation caused by nitrobenzene in the thyroid gland

Abstract: Melatonin can serve as an effective agent in protection against nitrobenzene-induced lipid peroxidation in porcine thyroid.

Cited by 10 publications

References 30 publications

Melatonin ameliorates ketoconazole-induced increase in thyroid function

Melatonin ameliorates ketoconazole-induced increase in thyroid function

Melatonin: shedding light on infertility? - a review of the recent literature

Changes in thyroid hormones, leptin, ghrelin and, galanin following oral melatonin administration in intact and castrated dogs: a preliminary study

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