Comparison of pregnancy outcomes in anonymous shared versus exclusive donor oocyte in vitro fertilization cycles

Mullin, Christine; Fino, Mary Elizabeth; Talebian, S.; Keegan, D.A.; Grifo, James A.; Licciardi, F.

doi:10.1016/j.fertnstert.2009.07.1669

Cited by 10 publications

(9 citation statements)

References 20 publications

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“…In agreement with our findings, most studies found that recipients who received higher number of oocytes have higher chances of freezing embryos [14]. Recently, Mullin et al compared exclusive and shared donor oocyte cycles and found no significant differences in clinical pregnancy rate among both types of donations; [13] however, and in agreement with our findings the group that received all the oocytes retrieved had a significantly greater number of cryopreserved embryos.…”

Section: Discussionsupporting

confidence: 92%

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A shared egg donor program: which is the minimum number of oocytes to be allocated?

Glujovsky¹,

Domínguez²,

Fiszbajn³

et al. 2010

J Assist Reprod Genet

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Purpose To evaluate which is the minimum number of oocytes to be allocated to each recipient in a shared egg donor program. Methods We analyzed 953 recipients that received at least 4 metaphase II (MII) oocytes in the period 2006-2008. We retrospectively divided the recipients according to the number of MII oocytes actually received.Results No statistically significant differences were found among the analyzed strata in clinical pregnancy rate (A:43.7%; B:45.6%; C:48.6%; D:45.5%; E:53%, P=NS) and miscarriage rate. However, the rate of top quality transferred embryos, and the embryo freezing rate were significantly higher among those recipients that received 7 or more mature eggs. Conclusions After a large sample was analyzed, no significant differences in fresh embryo transfer outcome were encountered when a different number of oocytes was allocated. A minimum of 4 MII oocytes seems to achieve satisfactory pregnancy rates in our shared egg donor program.

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Section: Discussionsupporting

confidence: 92%

“…This issue was the focus of several publications on egg sharing policies, and none of them showed that receiving more oocytes led to better reproductive outcomes [13,14]. Most allocation policies vary from a minimum of 4 oocytes to larger number such as 8 or 10 oocytes to each recipient.…”

Section: Introductionmentioning

confidence: 99%

A shared egg donor program: which is the minimum number of oocytes to be allocated?

Glujovsky¹,

Domínguez²,

Fiszbajn³

et al. 2010

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…Similar to Mullin et al, they did not fi nd any statistically signi fi cant difference in pregnancy or miscarriage rate in patients who had received 4, 5, 6, 7, and ³ 8 mature oocytes. Such results lend credence to the practice of sharing donors [ 27,28 ] . Despite comparable fresh pregnancy rates from shared and exclusive donor oocyte cycles, investigators in both studies did note a signi fi cant difference in the average number of excess good-quality embryos available for cryopreservation [ 27,28 ] .…”

Section: Are There Factors That Impact Upon the Success Of A Frozen Dsupporting

confidence: 56%

“…A shared donor oocyte program offers a solution to this "egg ef fi ciency" problem. Our group recently performed a retrospective analysis to examine whether there is a difference in pregnancy outcomes between women undergoing a shared ( n = 656) versus exclusive ( n = 225) donor oocyte cycles and did not fi nd a difference in the clinical pregnancy rates among these groups [ 27 ] . Although the exclusive group had signi fi cantly more oocytes (19.5 vs. 11.6) and fertilized embryos (11.9 vs. 7.3) when compared with the shared group, the pregnancy rates were quite similar (58 % vs. 56 %).…”

Section: Are There Factors That Impact Upon the Success Of A Frozen Dmentioning

confidence: 99%

What Is the Outcome and Fate of Frozen Supernumerary Embryos Resulting from Egg Donation?

Knopman

Licciardi

2013

Principles of Oocyte and Embryo Donation

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“…Oocyte donors underwent standard controlled ovarian hyperstimulation and oocyte retrieval [4]. Oocyte recipients were given estradiol, 6 mg orally per day to thicken the endometrium.…”

Section: Methodsmentioning

confidence: 99%

Using the oocyte donation model to identify early trophoblast pregnenolone production

Licciardi

Tan

2013

J Assist Reprod Genet

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Purpose To investigate production of progesterone's precursor, pregnenolone, in the early oocyte donation pregnancy. Methods Pregnenolone and progesterone were measured on luteal days 21, 28, 35, 60 and 80. Progesterone was measured via the Immulite system, pregnenolone by liquid chromatography separation with tandem mass spectrometric detection. Results Progesterone rose significantly from days 35 today 60. Pregnenolone likewise rose significantly from days 35-60, but at a much higher rate, with an increase of 57 % by day 60, 75 % to day 80. The increase in pregnenolone was statistically more significant than the increase in progesterone (p<.05). Conclusions This is the first report describing that progesterone's precursor, pregnenolone, increases with time in the very early pregnancy. Because no corpus luteum is present in oocyte recipients, the main source of pregnenolone is the early placenta. Measurements of pregnenolone may provide information concerning early trophoblast function and may represent a method of assessing placental competency.

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Comparison of pregnancy outcomes in anonymous shared versus exclusive donor oocyte in vitro fertilization cycles

Cited by 10 publications

References 20 publications

A shared egg donor program: which is the minimum number of oocytes to be allocated?

A shared egg donor program: which is the minimum number of oocytes to be allocated?

What Is the Outcome and Fate of Frozen Supernumerary Embryos Resulting from Egg Donation?

Using the oocyte donation model to identify early trophoblast pregnenolone production

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