Comparison of prenatal ultrasound and postmortem findings in fetuses and infants with congenital heart defects

Isaksen, C. V.; Eik‐Nes, S. H.; Blaas, H.‐G. K.; Tegnander, Eva; Torp, Sverre Helge

doi:10.1046/j.1469-0705.1999.13020117.x

Cited by 57 publications

(46 citation statements)

References 42 publications

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“…This further supports the good correlation usually found between prenatal scanning and autopsy of various organ malformations (Isaksen et al, 1998(Isaksen et al, , 1999.…”

Section: Discussionsupporting

confidence: 83%

Antenatal sonographic findings of right pulmonary agenesis with ipsilateral microtia: a possible new laterality association

et al. 2001

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“…This further supports the good correlation usually found between prenatal scanning and autopsy of various organ malformations (Isaksen et al, 1998(Isaksen et al, , 1999.…”

Section: Discussionsupporting

confidence: 83%

Antenatal sonographic findings of right pulmonary agenesis with ipsilateral microtia: a possible new laterality association

et al. 2001

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“…This important issue is discussed widely elsewhere [15][16][17][18][19][20] . Many Israeli couples are reluctant to consent to post-abortion autopsy.…”

Section: Discussionmentioning

confidence: 99%

Termination of Pregnancy due to Fetal Abnormalities Performed after 23 Weeks’ Gestation: Analysis of Indications in 144 Cases from a Single Medical Center

Vaknin¹,

Lahat²,

Barel³

et al. 2009

Fetal Diagn Ther

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Background/Aims: To assess the indications for late termination (≥23 weeks’ gestation) of pregnancy (LTOP), and to evaluate the rate of cases potentially diagnosable earlier. Methods: Cases of singleton pregnancy ending in LTOP due to fetal abnormalities in our institute between 1/1998 and 12/2005 were retrospectively reviewed. The women were divided into two groups according to the sequence of events that led to LTOP: Group 1 – the first test indicating an abnormal finding was performed ≤23 weeks’ gestation, but LTOP was performed >23 weeks; Group 2 – the first test indicating an abnormal finding was performed ≥23 weeks of gestation, or the fetal prognosis was not certain at the time of diagnosis and there was a medical recommendation to continue investigation. Results: There were 144 cases of LTOP (average gestational age 26.2 ± 3.4 weeks). More than 70% of the cases were aborted because of chromosomal/genetic indication in Group 1; many of them could have been detected earlier in pregnancy, while about 80% of the cases were aborted because of structural abnormalities in Group 2 (p < 0.001). The structural anomaly could have been diagnosed earlier in 56 cases (∼74%) if the pregnant woman had undergone an earlier anomaly scan. In another 13 cases (9%), fetal prognosis was not certain and continuing prenatal investigation was required. Conclusions: The most common indications for LTOP were structural abnormalities (91 cases, 70%) which included the central nervous system (26 cases, 29%), cardiac abnormalities (24 cases, 26%), and multiple malformations (18 cases, 20%). The diagnosis of fetal anomaly could have been made earlier in more than half of the pregnant women undergoing LTOP.

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“…The classification of heart defects was done retrospectively after a final diagnosis was made either by postnatal echocardiography or by autopsy. A perinatal pathologist performed the postmortem examinations20. The defects were classified as major or minor.…”

Section: Methodsmentioning

confidence: 99%

The examiner's ultrasound experience has a significant impact on the detection rate of congenital heart defects at the second‐trimester fetal examination

Tegnander

Eik‐Nes

2006

Ultrasound in Obstet & Gyne

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198

168

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show abstract

Comparison of prenatal ultrasound and postmortem findings in fetuses and infants with congenital heart defects

Cited by 57 publications

References 42 publications

Antenatal sonographic findings of right pulmonary agenesis with ipsilateral microtia: a possible new laterality association

Antenatal sonographic findings of right pulmonary agenesis with ipsilateral microtia: a possible new laterality association

Termination of Pregnancy due to Fetal Abnormalities Performed after 23 Weeks’ Gestation: Analysis of Indications in 144 Cases from a Single Medical Center

The examiner's ultrasound experience has a significant impact on the detection rate of congenital heart defects at the second‐trimester fetal examination

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