Comparison of Presepsin, Procalcitonin, Interleukin-8 and C-Reactive Protein in Predicting Bacteraemia in Febrile Neutropenic Adult Patients With Haematological Malignancies

Kostić, Irena; Gurrieri, Carmela; Piva, Elisa; Semenzato, Gianpietro; Plebani, Mario; Caputo, Ilaria; Vianello, Fabrizio

doi:10.4084/mjhid.2019.047

Cited by 8 publications

(5 citation statements)

References 24 publications

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“…The appearance of fever in neutropenic patients, called febrile neutropenia, is a serious complication that requires immediate hospitalization [40]. Therefore, we also examined the plasma level of C-reactive protein (CRP), which is a well-known marker for febrile neutropenia [41,42]. As with the pro-inflammatory cytokine/chemokines, CRP had two significant peaks over a 15-day observation period after 5-FU treatment (Figure 5D).…”

Section: Resultsmentioning

confidence: 99%

Mitigating Effect of 1-Palmitoyl-2-Linoleoyl-3-Acetyl-Rac-Glycerol (PLAG) on a Murine Model of 5-Fluorouracil-Induced Hematological Toxicity

Jeong

Kim²,

Lee³

et al. 2019

Cancers

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5-Fluorouracil (5-FU) is an antimetabolite chemotherapy widely used for the treatment of various cancers. However, many cancer patients experience hematological side effects following 5-FU treatment. Here, we investigated the protective effects of 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) as a mitigator against 5-FU-induced hematologic toxicity, including neutropenia, monocytopenia, thrombocytopenia, and thrombocytosis, in Balb/c mice injected with 5-FU (100 mg/kg, i.p.). Administration of PLAG significantly and dose-dependently reduced the duration of neutropenia and improved the nadirs of absolute neutrophil counts (ANCs). Moreover, while the ANCs of all mice in the control fell to the severely neutropenic range, none of the mice in the PLAG 200 and 400 mg/kg-treated groups experienced severe neutropenia. Administration of PLAG significantly delayed the mean first day of monocytopenia and reduced the duration of monocytopenia. PLAG also effectively reduced extreme changes in platelet counts induced by 5-FU treatment, thus preventing 5-FU-induced thrombocytopenia and thrombocytosis. PLAG significantly decreased plasma levels of the chemokine (C–X–C motif) ligand 1 (CXCL1), CXCL2, interleukin (IL)-6, and C-reactive protein (CRP), which were elevated consistently with the occurrence time of neutropenia, monocytopenia, and thrombocytopenia. When compared with olive oil and palmitic linoleic hydroxyl glycerol (PLH), only PLAG effectively mitigated 5-FU-induced hematological toxicity, indicating that it has a distinctive mechanism of action. In conclusion, PLAG may have therapeutic potential as a mitigator for 5-FU-induced neutropenia and other hematological disorders.

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Section: Resultsmentioning

confidence: 99%

Mitigating Effect of 1-Palmitoyl-2-Linoleoyl-3-Acetyl-Rac-Glycerol (PLAG) on a Murine Model of 5-Fluorouracil-Induced Hematological Toxicity

Jeong

Kim²,

Lee³

et al. 2019

Cancers

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“…However, CRP concentrations often increase in noninfectious complications and are nonspecific for infection. 24 PCT is rapidly produced by thyroid gland C cells and several other types of cells and is stimulated by bacterial endotoxins, lipopolysaccharides, or inflammatory modulators (eg, tumor necrosis factor-α, IL-6, IL-1). 25 PCT reportedly can distinguish infection from non-infection.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Risk Factors and Clinical Indicators in Bloodstream Infections Among Patients with Hematological Malignancy

Ma¹,

Wang²,

Yang³

et al. 2020

CMAR

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“…It is responsible for neutrophil recruitment, margination, and tissue infiltration. IL-8 has received attention as a marker of sepsis and bacteremia in people (26,27,34) and it may be a useful marker in dogs with polyarthritis, sepsis and trauma (13,35,36). Its specificity for sepsis is not known in cats, but increased IL-8 concentrations have been documented in the course of sterile inflammatory diseases like feline idiopathic cystitis and degenerative joint disease (20,22).…”

Section: Discussionmentioning

confidence: 99%

Cytokine and Chemokine Profiling in Cats With Sepsis and Septic Shock

et al. 2020

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Background: Sepsis is a life-threatening condition associated with an exacerbated production of both pro-and anti-inflammatory cytokines that can promote a hyperactive response to infection or induce immunoparalysis. Data regarding the immune response to sepsis in cats are scarce. Establishing the profiles of cytokines and chemokines in feline sepsis to characterize the nature of the immune responses to sepsis might enable individualized treatments to be developed and targeted. Objective: To evaluate the cytokine and chemokine network in cats with sepsis and septic shock, and to investigate the associations of these analytes with disease severity and outcome. Methods: Blood samples prospectively collected at presentation of cats with sepsis and septic shock to two veterinary teaching hospitals were analyzed. Forty healthy cats were included as controls. A 19-plex feline cytokine/chemokine magnetic bead assay system was used to measure analytes in citrated plasma samples. Cytokine concentrations were compared between groups using the Kruskal-Wallis test with Dunn's post-hoc correction for multiple comparisons. Cytokine concentrations were compared between survivors and non-survivors with the Mann-Whitney U test. Odds ratios were calculated using logistic regression. A multivariable logistic regression model for prediction of septic shock was constructed. Results: The study enrolled 35 septic cats. Many cytokines were undetectable in both sick and healthy control cats and were excluded from subsequent analyses. Comparisons of cytokine concentrations among healthy controls, cats with sepsis (n = 12) and cats with septic shock (n = 23) revealed that sick cats (sepsis or septic shock) had significantly higher plasma concentrations of IL-6, IL-8, KC-like, and RANTES compared to healthy controls. The combination of MCP-1, Flt-3L, and IL-12 was predictive of septic shock. None of the cytokines analyzed was predictive of outcome in this study population. Conclusion: Plasma concentrations of IL-6, IL-8, KC-like, and RANTES are increased in cats with sepsis and may play important roles in pathogenesis. Multivariable modeling suggested that analysis of cytokines might aid differentiation of septic shock from sepsis. None of the cytokines analyzed was predictive of outcome. Measurement of these cytokines might enable future studies to better diagnose and characterize feline sepsis and septic shock.

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Comparison of Presepsin, Procalcitonin, Interleukin-8 and C-Reactive Protein in Predicting Bacteraemia in Febrile Neutropenic Adult Patients With Haematological Malignancies

Cited by 8 publications

References 24 publications

Mitigating Effect of 1-Palmitoyl-2-Linoleoyl-3-Acetyl-Rac-Glycerol (PLAG) on a Murine Model of 5-Fluorouracil-Induced Hematological Toxicity

Mitigating Effect of 1-Palmitoyl-2-Linoleoyl-3-Acetyl-Rac-Glycerol (PLAG) on a Murine Model of 5-Fluorouracil-Induced Hematological Toxicity

Analysis of Risk Factors and Clinical Indicators in Bloodstream Infections Among Patients with Hematological Malignancy

Cytokine and Chemokine Profiling in Cats With Sepsis and Septic Shock

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