“…In such cases, both the fascicular signals and any adjacent fragmented myocardial signals might be potential targets of ablation. 19,51 However, earliest pre-Purkinje potentials may be recorded quite proximally in the His-Purkinje system with a high risk of AV block with ablation at such sites, and it may be prudent to initially target more distal prepotentials. 18,19 Ablation targeting the fascicular signals in the posteroseptal region may lead to exit of the PVCs using other fascicles and change in QRS axis.…”