Comparison of preventive effect of sildenafil and therapeutic effect of sildenafil treatment in rats with monocrotaline-induced pulmonary arterial hypertension

Yoshiyuki, Rieko; Fukushima, Ryuji; Tanaka, Ryou; Motomura, Noboru

doi:10.1292/jvms.15-0544

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…Previous studies have shown that MCT injection in rats resulted in enhanced RVSR, mPAP, RVH, increased pulmonary vessel wall thickness and PAH. These changes mainly lead to the development of PAH ( Yoshiyuki et al, 2016 ; Karpuz et al, 2017 ). In this study, we used MCT-induced PAH rat model to evaluate the effect of maprotiline.…”

Section: Discussionmentioning

confidence: 99%

Maprotiline Prevents Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats

et al. 2018

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Pulmonary arterial hypertension (PAH) is a progressive disease caused by increased pulmonary artery pressure and pulmonary vascular resistance, eventually leading to right heart failure until death. Soluble guanylate cyclase (sGC) has been regarded as an attractive drug target in treating PAH. In this study, we discovered that maprotiline, a tetracyclic antidepressant, bound to the full-length recombinant sGC with a high affinity (KD = 0.307 μM). Further study demonstrated that maprotiline concentration-dependently inhibited the proliferation of hypoxia-induced human pulmonary artery smooth muscle cells. Moreover, in a monocrotaline (MCT) rat model of PAH, maprotiline (ip, 10 mg/kg once daily) reduced pulmonary hypertension, inhibited the development of right ventricular hypertrophy and pathological changes of the pulmonary vascular remodeling. Taken together, our studies showed that maprotiline may contribute to attenuate disease progression of pulmonary hypertension.

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Section: Discussionmentioning

confidence: 99%

Maprotiline Prevents Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats

et al. 2018

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“…Several studies have demonstrated that these models produce distinct RV responses in terms of adaptive RV hypertrophy in the PAB model, in contrast to the maladaptive failure in the SuHx and MCT models ( 28 , 149 ). Several characteristics of maladaptive RV remodeling in the PAH model have been proposed, including RV dilation, reduced function, fibrosis, and capillary rarefication ( 29 , 150 ). However, as of the confounding effects of potentially altered pulmonary vascular resistance, hypoxia, molecular modulation (e.g., VEGF inhibition), or toxins on RV function, the MCT and SuHx models cannot be used to investigate isolated RV effects of potential therapies, and the PAB model is relevant in this regard ( 29 , 151 , 152 ).…”

Section: Surgical Modelsmentioning

confidence: 99%

A review on experimental surgical models and anesthetic protocols of heart failure in rats

et al. 2023

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Heart failure (HF) is a serious health and economic burden worldwide, and its prevalence is continuously increasing. Current medications effectively moderate the progression of symptoms, and there is a need for novel preventative and reparative treatments. The development of novel HF treatments requires the testing of potential therapeutic procedures in appropriate animal models of HF. During the past decades, murine models have been extensively used in fundamental and translational research studies to better understand the pathophysiological mechanisms of HF and develop more effective methods to prevent and control congestive HF. Proper surgical approaches and anesthetic protocols are the first steps in creating these models, and each successful approach requires a proper anesthetic protocol that maintains good recovery and high survival rates after surgery. However, each protocol may have shortcomings that limit the study's outcomes. In addition, the ethical regulations of animal welfare in certain countries prohibit the use of specific anesthetic agents, which are widely used to establish animal models. This review summarizes the most common and recent surgical models of HF and the anesthetic protocols used in rat models. We will highlight the surgical approach of each model, the use of anesthesia, and the limitations of the model in the study of the pathophysiology and therapeutic basis of common cardiovascular diseases.

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Soluble guanylate cyclase stimulator, trans-4-methoxy-β-nitrostyrene, has a beneficial effect in monocrotaline-induced pulmonary arterial hypertension in rats

Gonzaga-Costa

Vasconcelos-Silva

Rodrigues-Silva

et al. 2021

European Journal of Pharmacology

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Comparison of preventive effect of sildenafil and therapeutic effect of sildenafil treatment in rats with monocrotaline-induced pulmonary arterial hypertension

Cited by 3 publications

References 28 publications

Maprotiline Prevents Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats

Maprotiline Prevents Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats

A review on experimental surgical models and anesthetic protocols of heart failure in rats

Soluble guanylate cyclase stimulator, trans-4-methoxy-β-nitrostyrene, has a beneficial effect in monocrotaline-induced pulmonary arterial hypertension in rats

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