Comparison of Progressive Antithrombin Activity and the Concentrations of Three Thrombin Inhibitors in Human Plasma

Abildgaard, Ulrich; Fagerhol, Magne K.; Egeberg, O.

doi:10.3109/00365517009046245

Cited by 122 publications

(35 citation statements)

References 16 publications

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“…On the other hand, the lack of corre lation we observed between AT-III biologi cal activity and «,-AT or «2-M values in both treated and control subjects is compat ible with the concept that these inhibitors contribute only partially to the antithrombin capacity of plasma. Similarly, in a group of unsclected patients and in condition with low-progressive antithrombin (liver cirrho sis, thrombotic states), Abilgaard et al [1] have reported a good correlation between progressive AT-III and the corresponding AT-III immunological measurements, but no correlation between the former and AT or «.,-M immunological values.…”

Section: Discussionmentioning

confidence: 99%

Thrombin Inhibitors in Women on Oral Contraceptives

Guagnellini¹,

Bertolini²,

Cappelletti³

et al. 1981

Acta Haematol

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Progressive antithrombin activity and the immunological levels of antithrombin III, α₂-macroglobulin, and α₁-antitrypsin were measured in women at various intervals during treatment with oral contraceptives and in a group of untreated women. No significant changes were observed in any of the above parameters. In both control and treated women, there was a positive statistical correlation between progressive antithrombin activity and antithrombin III immunological levels, whereas no correlation was found between the former and α₁-antitrypsin or α₂-macroglobulin immunological levels. This study questions the possibility of thrombin inhibitors being selective signs of hypercoagulability during treatment with oral contraceptives.

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Section: Discussionmentioning

confidence: 99%

Thrombin Inhibitors in Women on Oral Contraceptives

Guagnellini¹,

Bertolini²,

Cappelletti³

et al. 1981

Acta Haematol

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“…It is known that the antithrombot ic potential of blood is dependent on the concentrations of «;M and AT III [10]. It has been suggested that an elevated level of coM may compensate for a decreased AT III level, and thus may offer a degree of protection from thrombosis [11], In one family of AT-III-deficient patients, mem bers with low AT III levels and a history of thrombosis tended to have lower levels than those patients with similarly low AT III levels who had not experienced a thrombotic problem [Winter, J.H., per sonal commun., 1982].…”

Section: Resultsmentioning

confidence: 99%

Chronic Inflammatory Bowel Disease, Deep-Venous Thrombosis and Antithrombin Activity

Ghosh¹,

Mackie²,

McVerry³

et al. 1983

Acta Haematol

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Of 34 patients with chronic inflammatory bowel disease (CIBD), 4 developed well-documented episodes of deep-venous thrombosis. All 4 patients had active disease at the time of thrombosis. This group was studied to determine if the tendency to deep-venous thrombosis in patients with CIBD was associated with reduced antithrombin activity by measuring the concentration of three thrombin inhibitors, antithrombin III (AT III), α₂-macroglobulin (α₂M) and α₁-antitrypsin. 2 patients had low AT III levels and 10 had low α₂M levels. 2 patients who developed deep-venous thrombosis had significantly low levels of both AT III and α₂M. It is suggested that in patients with diseases predisposing to thrombosis and associated with low AT III levels, the measurement of α₂M in addition to AT III may predict those particularly at risk.

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“…In the absence of these two conditions, AT levels below 50% of normal should raise the possibility of familial AT deficiency. There is usually good correlation between functional and antigenic AT levels, except in DIC (20) and in some cases of familial deficiency (2 1). The poor correlation in DIC probably reflects the fact that inactive AT, in the form of AT-coagulant enzyme complexes, is not immediately cleared from circulation.…”

Section: Lupus Anticoagulant Andmentioning

confidence: 99%