Comparison of Prolonged Prothrombin and Activated Partial Thromboplastin Time Results With Thrombelastograph Parameters

Abstract

Objective: The aim of this study was to investigate the performance and feasibility of the rotational thromboelastometry (ROTEM) profile by comparing prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT) results with ROTEM parameters.Methods: We tested external TEM (EXTEM)-and internal TEM (INTEM)-activated determinations, mainly focusing on 5 basic parameters: Clotting time (CT), clot formation time (CFT), a angle, clot formation rate (CFR), and maximum clot firmness (MCF). We then compared PT and APTT results with ROTEM parameters. Results:We observed no significant correlations between any of the ROTEM EXTEM or INTEM parameters and PT results. Similarly, only 1 parameter, the INTEM CT value, was significantly correlated with APTT results (r 2 = 0.165, P <.05).Conclusion: Much work is still needed to further evaluate ROTEM assay results stemming from clinical scenarios and standard laboratory testing.

Thromboelastometry and Thrombelastography Analysis under Normal Physiological Conditions - Systematic Review

“…Three studies reported the extent of association between thromboelastometry/thromboelastography parameters and conventional coagulation assays [31][32][33]. The details are reported in table 2.…”

“…Associations between thromboelastometry parameters and conventional parameters of hemostasis were investigated in one study only [31]. Kim and co-workers [31] correlated CT, CFT, α angle, CFR, and MCF with PT as well as aPTT.…”

“…Kim and co-workers [31] correlated CT, CFT, α angle, CFR, and MCF with PT as well as aPTT. No significant correlation was found between any EXTEM or INTEM parameters and PT.…”

Platelet Function Tests: A Review of Progresses in Clinical Application

“…The growing clinical need coupled with the development of new, simpler POCT machines has resulted in a tendency of platelet function tests to be done away from specialized clinical hemostasis laboratories. This review focuses on the clinical utility of two representative instruments: impact cone and plate analyzer (DiaMed, Cressier, Switzerland) [ 2 , 18 , 19 ] and thrombelastography (TEG) (Hemoscope, Niles, IL, USA) [ 7 – 10 , 21 , 22 ] in more detail, and the others are referred to below in the section of monitoring antiplatelet therapy.…”

“…Unlike other specific platelet function tests, these instruments have traditionally been used within surgical and anesthesiology departments for determining the risk of bleeding and as a guide for transfusion requirements. There is interlaboratory variation and it is a time-consuming analysis (at least 30 min) [ 7 – 10 , 21 , 22 ].…”