Comparison of Prooxidant-antioxidant Balance between Patients with High Grade Gliomas (IV) and Control Group

Abstract

Background & Aim: The most common primary brain tumors of the central nervous system are gliomas. Among a number of different biomolecular events, a strong relation between oxidative stress pathways and the development of this cancer has been proved. Oxidative stress (OS) is the consequence of an imbalance between pro-oxidants and antioxidants towards pro-oxidants. The pro-oxidants cause lipid peroxidation of cell membranes, protein, DNA oxidation and changes in brain cell growth. In this study, the pro-oxidant-antioxidant balance (PAB) was determined in patients with gliomas.Methods & Materials/Patients: Sera of 49 patients with high grade glioma (grade IV WHO) which is called glioblastoma multiform (GBM) and 49 healthy subjects were collected and PAB test was measured.Results: A significant increase of PAB value was observed in patients with GBM (158.10±85.71 HK unit) in comparison to control group (74.54±33.54 HK). Conclusion:The PAB assay showed the oxidative stress in glioblastoma. In further research, this easy elucidation of oxidative stress in these patients can be applied to evaluate the effectiveness of antioxidant therapies in patients with GBM

The effects of propolis on pro-oxidant–antioxidant balance, glycemic control, and quality of life in chronic kidney disease: a randomized, double-blind, placebo-controlled trial

“…Oxidative stress is defined as a state of imbalance between pro-oxidants and antioxidants in favor of pro-oxidants 17 . It plays a pivotal role in the progression of CKD, directly by inducing tubular and glomerular injury or indirectly by developing HTN, inflammation, and/or endothelial dysfunction 11 , 21 ; therefore, the effects of propolis on OS in CKD patients was evaluated in the current study.…”

“…All biochemical measurements except PAB were performed immediately after sampling. Pro-oxidant–antioxidant balance assay was done as described by Faraji-Rad et al 17 . Insulin sensitivity and insulin resistance were calculated by quantitative insulin sensitivity check index (QUICKI) and homeostasis model of assessment-insulin resistance (HOMA-IR), respectively 18 , 19 : …”

The effect of zingiber officinale on prooxidant-antioxidant balance and glycemic control in diabetic patients with ESRD undergoing hemodialysis: a double-blind randomized control trial

“…The homeostatic model evaluation of insulin resistance (HOMA-IR = [FBG (mg/ dl) × fasting insulin (µu/ml)] ∕ 405) was used to determine insulin resistance. A prior approach established by Faraji-Rad et al [26] was used to assess the PAB.…”

Understanding the glioblastoma tumor biology to optimize photodynamic therapy: From molecular to cellular events

“…However, in one way or another, unfailingly GBM patients are associated with a high level of pro-oxidant signatures which indicates the presence of oxidative stress (Faraji-Rad et al, 2015).…”

“…In this sense, it is still not entirely clear which event materializes first to promote gliomagenesis, whether there is a DNA mutation as result of an imbalance in the redox status or if alterations in key genes led to an increased production of ROS that benefit gliomagenesis. However, in one way or another, unfailingly GBM patients are associated with a high level of pro‐oxidant signatures which indicates the presence of oxidative stress (Faraji‐Rad et al., 2015).…”