Comparison of prophylactic effect of topical Alchemilla vulgaris in glycerine versus that of dexamethasone on postoperative sore throat after tracheal intubation using a double-lumen endobronchial tube: a randomized controlled study

Abstract

Background: Sore throat and hoarseness frequently occur following general anesthesia with tracheal intubation and are effectively reduced when dexamethasone is used prophylactically. Alchemilla vulgaris in glycerine (Neo Mucosal Activator®) suppresses inflammatory response, possibly relieving sore throat.Methods: We enrolled 94 patients (age ≥ 18 years) scheduled for thoracic surgery using double-lumen tube intubation. Before intubation, 0.2 mg/kg of dexamethasone was administered intravenously and 2 ml of normal saline was sprayed into the oropharyngeal cavity (Group D; n = 45), or 0.04 ml/kg normal saline was administered intravenously and 1 g of Neo Mucosal Activator® mixed with 1 ml of normal saline was sprayed into the oropharyngeal cavity (Group N; n = 43), in a double blind and prospectively randomized manner. Postoperative sore throat and hoarseness were recorded using a numeral rating scale and a 4-point scale to detect a change in voice quality following tracheal extubation (at 1, 6, and 24 h). The primary outcome was the incidence of sore throat at 24 h following surgery. The secondary outcomes were incidence and severity of sore throat and hoarseness.Results: There were no significant differences in the incidence of sore throat at 24 h following surgery (57.8% vs. 46.5%; P = 0.290) or in the incidence and intensity of sore throat and hoarseness at 1, 6, and 24 h following surgery between the groups. Conclusions: A. vulgaris in glycerine did not significantly differ from dexamethasone for preventing sore throat and hoarseness owing to intubation.

Effect of intratracheal dexmedetomidine combined with ropivacaine on postoperative sore throat: a prospective randomised double-blinded controlled trial

“…In the current study, the HR decreased with the application of dexmedetomidine, but only rare episodes of bradycardia requiring atropine were observed. Most likely, because these complications occur more often in elderly patients with cardiac disease or given high dosages of dexmedetomidine intravenously [ 3 ], we restricted enrolment to ASA I-II patients, and intratracheal administration resulted in slower effects than intravenous administration. Moreover, sedation scores were measured in the assessments of outcomes.…”

“…Even though POST is a minor adverse event during anaesthesia recovery [ 2 ], it causes discomfort for the patient and reduces patient satisfaction with anaesthesia. POST was recently reported to have an incidence of up to 62% after general anaesthesia [ 3 ]. The incidence of POST is correlated with age, sex, tracheal tube size, endotracheal tube cuff pressure and other factors [ 4 ].…”