Comparison of propofol and the combination of propofol and alfentanil during bronchoscopy: a randomized study

Yoon, Ho Il; Kim, Jinhee; Lee, J. H.; Park, Sang Hyun; Lee, Choon Taek; Hwang, Jin Young; Nahm, Sahngun Francis; Han, Sung Hee

doi:10.1111/j.1399-6576.2010.02336.x

Cited by 35 publications

(32 citation statements)

References 31 publications

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“…17 showed that, with the routine provision of supplemental oxygen during bronchoscopy, propofol did not cause a greater fall in peripheral oxygen saturation than a combination of midazolam and hydrocodone. Yoon et al 20 reported greater respiratory depression in patients receiving a combination of propofol and alfentanil than in those receiving propofol alone. All these trials assessed medical patients or outpatients; data from evaluation of the respiratory effects of sedation during bronchoscopy in postoperative patients requiring intensive care are limited.…”

Section: Dexmedetomidine Versus Midazolam Sedation In Bronchoscopymentioning

confidence: 99%

Dexmedetomidine versus Midazolam for Conscious Sedation in Postoperative Patients Undergoing Flexible Bronchoscopy: A Randomized Study

Liao

Gertz

et al. 2012

J Int Med Res

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OBJECTIVE: This prospective randomized study evaluated the efficacy and patient tolerance of dexmedetomidine compared with midazolam for sedation in postoperative patients undergoing flexible bronchoscopy. METHODS: A total of 198 postoperative patients were randomized to receive dexmedetomidine (n = 99) or midazolam (n = 99) to produce conscious sedation for bronchoscopy. Peripheral oxygen saturation, heart rate and systolic and diastolic arterial pressures were recorded before, during and after the procedure. Patient tolerance was recorded using various visual analogue scales. RESULTS: The mean lowest peripheral oxygen saturation was significantly lower in the midazolam group than in the dexmedetomidine group. Heart rate and systolic arterial pressure were both significantly higher during bronchoscopy in the midazolam group than in the dexmedetomidine group. Bronchoscopy was well tolerated in both groups; there was no betweengroup difference in patient discomfort scores or in the percentage of patients who would accept repeat bronchoscopy. CONCLUSIONS:Compared with midazolam, dexmedetomidine provided better oxygen saturation and was equally well tolerated for conscious sedation in postoperative patients undergoing bronchoscopy.

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Section: Dexmedetomidine Versus Midazolam Sedation In Bronchoscopymentioning

confidence: 99%

Dexmedetomidine versus Midazolam for Conscious Sedation in Postoperative Patients Undergoing Flexible Bronchoscopy: A Randomized Study

Liao

Gertz

et al. 2012

J Int Med Res

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“…Propofol, analjezi sağlamak, öksürüğü azaltmak, gerekli propofol dozunu azaltmak ve anestezi ve sedasyonu artırmak için opiyat ve sedatiflerle kombinasyon tedavisinde de kullanılabilir (20,21). Propofol-opiyat kombinasyonu (orta düzeyde sedasyon) ile oksijen desatürasyonları arasında ilişki bulunmuş ancak bazı çalışmalarda midazolamın kısa etkili opiyatlarla kombinasyonu propofolün tek başına kullanımı ile karşılaştırıldığında daha fazla CO 2 retansiyonu ve daha fazla O 2 desteğine ihtiyaç ile sonuçlandığı gösterilmiştir (22,23). Başka bir çalışma-da, propofol ve benzodiazepin gruplarının her ikisinde de oksijen satürasyonlarında düşme gösterilmiş, ancak propofol grubunda (ortalama O 2 satürasyonu %83) benzodiazepin grubuna (%86) göre daha belirgin olduğu belirtilmiştir (24).…”

Section: Propofolunclassified

Sedation for fiberoptic bronchoscopy: review of the literature

Talay¹,

Kargi²,

Yaşar³

et al. 2015

Tuberk Toraks

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“…Beim Einsatz von Sedativa ist jederzeit mit Blutdruckabfällen [17], Hypoxämien [18], aber auch mit Herzrhythmusstörungen zu rechnen [19,20]. …”

Section: Monitoringunclassified

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2011

Pneumologie

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Comparison of propofol and the combination of propofol and alfentanil during bronchoscopy: a randomized study

Abstract: the combination of propofol and alfentanil resulted in a greater respiratory depression than propofol alone; furthermore, the addition of an opioid did not improve the quality of sedation. In conclusion, we do not recommend sedation with propofol and alfentanil during bronchoscopy.

Cited by 35 publications

References 31 publications

Dexmedetomidine versus Midazolam for Conscious Sedation in Postoperative Patients Undergoing Flexible Bronchoscopy: A Randomized Study

Dexmedetomidine versus Midazolam for Conscious Sedation in Postoperative Patients Undergoing Flexible Bronchoscopy: A Randomized Study

Sedation for fiberoptic bronchoscopy: review of the literature

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