Comparison of Prostaglandin E1 and Norepinephrine on the Gastric Mucosal Circulation

Jacobson, Eugene D.

doi:10.3181/00379727-133-34509

Cited by 115 publications

(37 citation statements)

References 6 publications

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“…From the results of Jacobson (1970) it can be shown that Rc/a also rose during prostaglandin El inhibition of both stimuli, lending further support to his conclusion that inhibition cannot be secondary to a reduction in MBF. In the rat, R,/a increased markedly during inhibition of pentagastrin-and histamine-induced secretion by prostaglandin E1 and E2.…”

Section: Discussionsupporting

confidence: 63%

“…In the dog, Wilson & Levine (1969) and Jacobson (1970) showed that prostaglandin E1 reduced MBF (as measured by aminopyrine clearance) an effect which the former authors considered to be responsible for the concurrent secretory inhibition. In the rat, prostaglandins E1 and E2 likewise caused a fall in clearance during inhibition of acid secretion although in some experiments clearance rose initially at a time when acid output was already decreasing.…”

Section: Discussionmentioning

confidence: 99%

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The effects of E and A prostaglandins on gastric mucosal blood flow and acid secretion in the rat

Main

Whittle

1973

British J Pharmacology

153

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Summary The effects of prostaglandins E1, E2, A1 and A2 on gastric acid secretion and mucosal blood flow were studied by means of a [14C]‐aniline clearance technique in the anaesthetized rat. During intravenous administration of these prostaglandins, in doses which almost completely inhibited pentagastrin‐ and histamine‐induced acid secretion, a fall in clearance was observed. Clearance per unit acid secretion increased during prostaglandin administration, precluding a primary reduction in mucosal blood flow as the mechanism of the antisecretory action. Prostaglandins increased clearance during basal secretion, indicating a direct vasodilator effect on the gastric mucosa. The possibility that endogenous prostaglandins contribute to functional vasodilatation in the gastric mucosa and that exogenous prostaglandins may be of clinical value in the treatment of peptic ulcer is discussed.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

The effects of E and A prostaglandins on gastric mucosal blood flow and acid secretion in the rat

Main

Whittle

1973

British J Pharmacology

153

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“…Such evidence as exists is largely inferred from results of experiments in which infusions of catecholamines have resulted in a reduction of acid secretion (Forrest & Code, 1954). Recently Jacobson (1970) reported that I.v. infusion of noradrenaline in conscious dogs during either histamine or gastrin stimulated acid secretion, produced a reduction in both acid output and mucosal blood flow.…”

Section: Discussionmentioning

confidence: 99%

The effect of splanchnic nerve stimulation on gastric acid secretion and mucosal blood flow in the anaesthetized cat

Reed¹,

Sanders²,

Thorpe³

1971

The Journal of Physiology

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SUMMARY1. Electrical stimulation of the vagus nerves produced a parallel increase in gastric acid secretion and gastric mucosal blood flow.2. Gastric acid secretion and mucosal blood flow, stimulated by pentapeptide infusions or by vagal stimulation, were markedly and equally reduced by electrical stimulation of splanchnic nerve fibres.3. The splanchnic stimulated reduction in acid and mucosal blood flow occurred only when the rise in blood pressure, normally associated with splanchnic stimulation, was prevented by inclusion of a pressure reservoir in the circulation.4. There was evidence that the effect of the splanchnic nerves was not mediated by release of adrenaline from the adrenal medulla.

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“…This is confirmed by the finding that the ratio of mucosal blood flow to secretion actually increases in response to isoprenaline. It was pointed out by Jacobson (1970) that any procedure which causes a decrease in acid secretion is likely to cause a decrease in mucosal blood flow because the level of blood flow is controlled by the metabolic requirements of the secretory tissue. In a comparison of the effects of noradrenaline and a prostaglandin, Jacobson concluded that the prostaglandin probably had a direct action on secretion because it increased the ratio of blood flow to secretion.…”

Section: Discussionmentioning

confidence: 99%

“…This field has recently been reviewed by Holton (1972). The mechanism of action of noradrenaline, an .a-adrenoceptor agonist, appears to be primarily by the production of a decrease in mucosal blood flow (Jacobson, 1970). The mechanism of action of the 3-adrenoceptor agonist, isoprenaline, is more complex.…”

Section: Introductionmentioning

confidence: 99%

The effects of isoprenaline and noradrenaline on pentagastrin‐stimulated gastric acid secretion and mucosal blood flow in the dog

Curwain

Holton

1972

British J Pharmacology

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Summary1. Isoprenaline (002 to 2-0 ,ug kg-' min-') inhibited gastric secretion in response to pentagastrin in both conscious and anaesthetized dogs and in response to feeding in conscious dogs.2. The inhibition was unaffected during cardiac f8-adrenoceptor blockade by propranolol. 3. The inhibition was not due to decreased mucosal blood flow. 4. This effect of isoprenaline is different from its effect on histamine-induced gastric secretion. 5. Noradrenaline (005-2-0 ,ug kg-' min') also decreased gastric secretion but it was less effective than isoprenaline. 6. The mechanism of action of noradrenaline is probably a decrease in mucosal blood flow. IntroductionThe effect of an adrenoceptor stimulant drug on gastric secretion depends on many factors, particularly whether it acts on a-or ,8-receptors and whether secretion is induced by histamine or by gastrin-like compounds. This field has recently been reviewed by Holton (1972). The mechanism of action of noradrenaline, an .a-adrenoceptor agonist, appears to be primarily by the production of a decrease in mucosal blood flow (Jacobson, 1970). The mechanism of action of the 3-adrenoceptor agonist, isoprenaline, is more complex. On a background of histamine stimulation, small doses of isoprenaline increase or do not affect secretion

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Comparison of Prostaglandin E1 and Norepinephrine on the Gastric Mucosal Circulation

Cited by 115 publications

References 6 publications

The effects of E and A prostaglandins on gastric mucosal blood flow and acid secretion in the rat

The effects of E and A prostaglandins on gastric mucosal blood flow and acid secretion in the rat

The effect of splanchnic nerve stimulation on gastric acid secretion and mucosal blood flow in the anaesthetized cat

The effects of isoprenaline and noradrenaline on pentagastrin‐stimulated gastric acid secretion and mucosal blood flow in the dog

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